Endolysosomal Cation Channels and Cancer—A Link with Great Potential

Davidson, 2017, Critical Functions of the Lysosome in Cancer Biology, Annu. Rev. Pharmacol. Toxicol., 57, 481, 10.1146/annurev-pharmtox-010715-103101

Piao, 2016, Targeting the lysosome in cancer, Ann. N Y Acad. Sci., 1371, 45, 10.1111/nyas.12953

Saftig, 2013, Cancer: Killing from the inside, Nature, 502, 312, 10.1038/nature12692

Dingle, 1969, Lysosomes and cancer, Lysosomes in Biology and Pathology, Volume 2, 178

Allison, 1974, Lysosomes in cancer cells, J. Clin. Pathol. Suppl., 7, 43, 10.1136/jcp.27.Suppl_7.43

Dingle, 1973, Tumour lysosomal enzymes and invasive growth, Lysosomes in Biology and Pathology, Volume 3, 83

Fennelly, 2017, Lysosomal Biology in Cancer, Methods Mol. Biol., 1594, 293, 10.1007/978-1-4939-6934-0_19

Leanza, 2013, Intracellular ion channels and cancer, Front. Physiol., 4, 227, 10.3389/fphys.2013.00227

Peruzzo, 2016, Impact of intracellular ion channels on cancer development and progression, Eur. Biophys. J., 45, 685, 10.1007/s00249-016-1143-0

Gautier, 2014, New insights into pharmacological tools to TR(i)P cancer up, Br. J. Pharmacol., 171, 2582, 10.1111/bph.12561

Shapovalov, 2016, Role of TRP ion channels in cancer and tumorigenesis, Semin. Immunopathol., 38, 357, 10.1007/s00281-015-0525-1

Grimm, 2017, From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease, Cell Calcium, 67, 148, 10.1016/j.ceca.2017.04.003

Nguyen, 2017, Two-pore channel function is crucial for migration of invasive cancer cells, Cancer Res., 77, 1427, 10.1158/0008-5472.CAN-16-0852

Nomura, 2005, Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells, J. Med. Investig., 52, 1, 10.2152/jmi.52.1

Mohamed, 2006, Cysteine cathepsins: Multifunctional enzymes in cancer, Nat. Rev. Cancer, 6, 764, 10.1038/nrc1949

Tardy, 2006, Lysosomes and lysosomal proteins in cancer cell death (new players of an old struggle), Biochim. Biophys. Acta, 1765, 101

Kallunki, 2013, Cancer-associated lysosomal changes: Friends or foes?, Oncogene, 32, 1995, 10.1038/onc.2012.292

Kirkegaard, 2009, Lysosomal involvement in cell death and cancer, Biochim. Biophys. Acta, 1793, 746, 10.1016/j.bbamcr.2008.09.008

Easton, 2006, mTOR and cancer therapy, Oncogene, 25, 6436, 10.1038/sj.onc.1209886

Nasrallah, 2017, Cancer: Linking Powerhouses to Suicidal Bags, Front. Oncol., 7, 204, 10.3389/fonc.2017.00204

Lopes, 2012, The mTOR signalling pathway in human cancer, Int. J. Mol. Sci., 13, 1886, 10.3390/ijms13021886

Brown, 1995, Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells, J. Cell Biol., 130, 781, 10.1083/jcb.130.4.781

Mousavi, 2003, Phosphoinositide 3-kinase regulates maturation of lysosomes in rat hepatocytes, Biochem. J., 372, 861, 10.1042/bj20021136

Collins, D., Chenard-Poirier, M., and Lopez, J. (2017). The PI3K pathway at the crossroads of cancer and the immune system: Strategies for next generation immunotherapy combinations. Curr. Cancer Drug Targets, 26.

LoPiccolo, 2008, Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations, Drug Resist. Updates, 11, 32, 10.1016/j.drup.2007.11.003

Wiedmann, 2012, The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1, Cancer Res., 72, 5976, 10.1158/0008-5472.CAN-12-1772

Bartel, 2017, V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling—A new option for HCC therapy, Oncotarget, 8, 9476, 10.18632/oncotarget.14339

2016, Lysosomes in cancer-living on the edge (of the cell), Curr. Opin. Cell Biol., 39, 69, 10.1016/j.ceb.2016.02.009

Klinosky, 2016, Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy, 12, 1, 10.1080/15548627.2015.1100356

Landskron, 2014, Chronic inflammation and cytokines in the tumor microenvironment, J. Immunol. Res., 2014, 149185, 10.1155/2014/149185

Camoglio, 1998, Altered expression of interferon-gamma and interleukin-4 in inflammatory bowel disease, Inflamm. Bowel Dis., 4, 285, 10.1097/00054725-199811000-00005

Shacter, 2002, Chronic inflammation and cancer, Oncology, 16, 217

Coussens, 2002, Inflammation and cancer, Nature, 420, 860, 10.1038/nature01322

Bretou, 2017, Lysosome signaling controls the migration of dendritic cells, Sci. Immunol., 2, eaak9573, 10.1126/sciimmunol.aak9573

Chen, 2017, Small molecules for early endosome specific patch-clamping, Cell Chem. Biol., 24, 907, 10.1016/j.chembiol.2017.05.025

Sun, 2015, Novel Role of TRPML2 in the Regulation of the Innate Immune Response, J. Immunol., 195, 4922, 10.4049/jimmunol.1500163

Parrington, 2015, Calcium signals regulated by NAADP and two-pore channels—Their role in development, differentiation and cancer, Int. J. Dev. Biol., 59, 341, 10.1387/ijdb.150211jp

Huttenlocher, 2011, Integrins in cell migration, Cold Spring Harb. Perspect. Biol., 3, a005074, 10.1101/cshperspect.a005074

Paul, 2015, Endocytic Trafficking of Integrins in Cell Migration, Curr. Biol., 25, R1092, 10.1016/j.cub.2015.09.049

Grimm, 2014, High susceptibility to fatty liver disease in two-pore channel 2-deficient mice, Nat. Commun., 5, 4699, 10.1038/ncomms5699

Pafumi, 2017, Naringenin Impairs Two-Pore Channel 2 Activity and Inhibits VEGF-Induced Angiogenesis, Sci. Rep., 7, 5121, 10.1038/s41598-017-04974-1

Favia, 2014, VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling, Proc. Natl. Acad. Sci. USA, 111, E4706, 10.1073/pnas.1406029111

Cang, 2013, mTOR regulates lysosomal ATP-sensitive two-pore Na+ channels to adapt to metabolic state, Cell, 152, 778, 10.1016/j.cell.2013.01.023

Laplante, 2009, mTOR signaling at a glance, J. Cell Sci., 122, 3589, 10.1242/jcs.051011

Li, 2016, Regulation of mTORC1 by lysosomal calcium and calmodulin, eLife, 5, e19360, 10.7554/eLife.19360

Medina, 2015, Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB, Nat. Cell Biol., 17, 288, 10.1038/ncb3114

Palmieri, 2011, Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways, Hum. Mol. Genet., 20, 3852, 10.1093/hmg/ddr306

Sardiello, 2009, A gene network regulating lysosomal biogenesis and function, Science, 325, 473, 10.1126/science.1174447

Haberkant, 2015, Intracellular sphingosine releases calcium from lysosomes, eLife, 4, e10616, 10.7554/eLife.10616

Medina, 2018, TRPML1: The Ca2+ retaker of the lysosome, Cell Calcium, 69, 112, 10.1016/j.ceca.2017.06.006

Marchand, 2015, Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells, J. Biol. Chem., 290, 5592, 10.1074/jbc.M114.616714

Giatromanolaki, 2015, Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer, Lung Cancer, 90, 98, 10.1016/j.lungcan.2015.07.008

Kors, 2016, Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling, eLife, 5, e17047, 10.7554/eLife.17047

Petit, 2012, The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis, Sci. Signal., 5, ra42

Perera, 2015, Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism, Nature, 524, 361, 10.1038/nature14587

Settembre, 2013, TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop, Nat. Cell Biol., 15, 647, 10.1038/ncb2718

Samie, 2013, A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis, Dev. Cell, 26, 511, 10.1016/j.devcel.2013.08.003

Park, 2016, Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV, EMBO Rep., 17, 266, 10.15252/embr.201541542

Ravi, 2016, Biphasic regulation of lysosomal exocytosis by oxidative stress, Cell Calcium, 60, 356, 10.1016/j.ceca.2016.08.002

Li, 2016, A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation, Nat. Cell Biol., 18, 404, 10.1038/ncb3324

Machado, 2015, Regulated lysosomal exocytosis mediates cancer progression, Sci. Adv., 1, e1500603, 10.1126/sciadv.1500603

Morelli, 2016, Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: Role in tumor growth and progression, Oncotarget, 7, 43654, 10.18632/oncotarget.9661