Inflammation and Neuro-Immune Dysregulations in Autism Spectrum Disorders

Pharmaceuticals - Tập 11 Số 2 - Trang 56
Dario Siniscalco1,2,3, Stanley G. Schultz4, Anna Lisa Brigida3, Nicola Antonucci5
1Centre for Autism—La Forza del Silenzio, 81036 Caserta, Italy
2Department of Experimental Medicine, University of Campania, 80138 Naples, Italy
3Italian Group for Study Autism—GISA, 25018 Brescia, Italy
4Department of Cellular and Integrative Physiology, School of Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA
5Biomedical Centre for Autism Research and Treatment, 70124 Bari, Italy

Tóm tắt

Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and interaction and restricted-repetitive patterns of behavior, interests, or activities. Strong inflammation states are associated with ASD. This inflammatory condition is often linked to immune system dysfunction. Several cell types are enrolled to trigger and sustain these processes. Neuro-inflammation and neuro-immune abnormalities have now been established in ASD as key factors in its development and maintenance. In this review, we will explore inflammatory conditions, dysfunctions in neuro-immune cross-talk, and immune system treatments in ASD management.

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