Lactoferrin from Milk: Nutraceutical and Pharmacological Properties
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Sorensen, 1939, The proteins in whey, Comptes-rendus des Trav. du Lab. Carlsberg, 23, 55
Groves, 1960, The isolation of a red protein from milk, J. Am. Chem. Soc., 82, 3345, 10.1021/ja01498a029
2009, Lactoferrin: Structure, function and applications, Int. J. Antimicrob. Agents, 33, 301.e1
Brock, 1995, Lactoferrin: A multifunctional immunoregulatory protein?, Immunol. Today, 16, 417, 10.1016/0167-5699(95)80016-6
Iyer, 1995, Lactoferrin: Molecular structure and biological function, Annu. Rev. Nutr., 15, 93, 10.1146/annurev.nu.15.070195.000521
Vorland, 1999, Lactoferrin: A multifunctional glycoprotein, APMIS, 107, 971, 10.1111/j.1699-0463.1999.tb01499.x
Valenti, 2005, Lactoferrin: An important host defence against microbial and viral attack, Cell Mol. Life Sci., 62, 2576, 10.1007/s00018-005-5372-0
Baker, 2009, A structural framework for understanding the multifunctional character of lactoferrin, Biochimie, 91, 3, 10.1016/j.biochi.2008.05.006
Leboffe, 2009, Antifungal and antiparasitic activities of lactoferrin, Anti-Infect. Agents Med. Chem., 8, 114, 10.2174/187152109787846105
Zhang, 2014, Anticancer effects of lactoferrin: Underlying mechanisms and future trends in cancer therapy, Nutr. Rev., 72, 763, 10.1111/nure.12155
Giansanti, 2015, The nutraceutical properties of ovotransferrin and its potential utilization as a functional food, Nutrients, 7, 9105, 10.3390/nu7115453
Giansanti, 2012, Physiolgical roles of ovotransferrin, Biochim. Biophys. Acta Gen. Subj., 1820, 218, 10.1016/j.bbagen.2011.08.004
Connely, 2001, Antiinflammatory activities of lactoferrin, J. Am. Coll. Nutr., 20, 389S, 10.1080/07315724.2001.10719173
Rodriguez, 2005, Antimicrobial mechanisms and potential clinical application of lactoferrin, Rev. Latino. Microbiol., 47, 102
Beljaars, 2001, Antiviral activities of lactoferrin, Antivir. Res., 52, 225, 10.1016/S0166-3542(01)00195-4
2005, Lactoferrin: A multifunctional protein, Adv. Mol. Med., 1, 149
Bennett, 2005, Lactoferrin content of peripheral blood cells, Br. J. Haematol., 39, 509, 10.1111/j.1365-2141.1978.tb03620.x
Anderson, 1987, Structure of human lactoferrin at 3.2-Å resolution, Proc. Natl. Acad. Sci. USA, 84, 1769, 10.1073/pnas.84.7.1769
Anderson, 1989, Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2.8 Å resolution, J. Mol. Biol., 209, 711, 10.1016/0022-2836(89)90602-5
Baker, 1994, Structure and reactivity of transferrins, Adv. Inorg. Chem., 41, 389, 10.1016/S0898-8838(08)60176-2
Moore, 1997, Threedimensional structure of diferric bovine lactoferrin at 2.8 Å resolution, J. Mol. Biol., 274, 222, 10.1006/jmbi.1997.1386
Eswar, 2006, Comparative protein structure modeling using MODELLER, Curr. Protoc. Bioinform., 8, 5
Pettersen, 2004, UCSF Chimera—A visualization system for exploratory research and analysis, J. Comput. Chem., 25, 1605, 10.1002/jcc.20084
Rastogi, 2016, Structure of iron saturated C-lobe of bovine lactoferrin at pH 6.8 indicates a weakening of iron coordination, Proteins: Struct. Funct. Bioinform., 84, 591, 10.1002/prot.25004
Loehr, T. (1989). Iron Carriers and Iron Proteins, VCH.
Baker, 1994, Three-dimensional structure of lactoferrin in various functional states, Adv. Exp. Med. Biol., 357, 1, 10.1007/978-1-4615-2548-6_1
Baker, 2005, Molecular structure, binding properties and dynamics of lactoferrin, Cell Mol. Life Sci., 62, 2531, 10.1007/s00018-005-5368-9
Baker, 2012, A structural perspective on lactoferrin function, Biochem. Cell Biol., 90, 320, 10.1139/o11-071
Rulis, A.M. Agency Response Letter GRAS Notice No. GRN 000077, Available online: http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/ucm154188.htm.
EFSA. Panel on Dietetic Products, Nutrition and Allergies (NDA) (2012). Scientific Opinion on bovine lactoferrin. EFSA J., 10, 2811.
Onishi, 2011, Lactoferrin delivery systems: Approaches for its more effective use, Expert. Opin. Drug Deliv., 8, 1469, 10.1517/17425247.2011.615829
Akiyama, 2013, A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells, J. Biochem., 154, 437, 10.1093/jb/mvt073
Bullen, 1981, The significance of iron in infection, Rev. Infect. Dis., 3, 1127, 10.1093/clinids/3.6.1127
Braun, 2002, Active transport of iron and siderophore antibiotics, Curr. Opin. Microbiol., 5, 194, 10.1016/S1369-5274(02)00298-9
Bullen, 1972, Iron-binding proteins in milk and resistance to Escherichia coli infection in infants, Proc. R. Soc. Med., 65, 1086
Weinberg, 2001, Human lactoferrin: A novel therapeutic with broad spectrumpotential, J. Pharm. Pharmacol., 53, 1303, 10.1211/0022357011777792
Tomita, 2002, Bovine lactoferrin and lactoferricin derived from milk: Production and applications, Biochem. Cell Biol., 80, 109, 10.1139/o01-230
Teraguchi, 2004, Protection against infections by oral lactoferrin: Evaluation in animal models, Biometals, 17, 231, 10.1023/B:BIOM.0000027697.83706.32
Aragona, 2003, Use of bovine lactoferrin for helicobacter pylori eradication, Dig. Liver Dis., 35, 706, 10.1016/S1590-8658(03)00409-2
Yekta, 2011, Reduction of Escherichia coli O157: H7 excretion in sheep by oral lactoferrin administration, Vet. Microbiol., 150, 373, 10.1016/j.vetmic.2011.02.052
Welsh, 2011, Influence of oral lactoferrin on Mycobacterium tuberculosis induced immunopathology, Tuberculosis, 91, S105, 10.1016/j.tube.2011.10.019
Velliyagounder, 2015, Oral lactoferrin protects against experimental candidiasis in mice, J. Appl. Microbiol., 118, 212, 10.1111/jam.12666
Sherman, 2004, Neonatal small bowel epithelia: Enhancing anti-bacterial defense with lactoferrin and Lactobacillus GG, Biometals, 17, 285, 10.1023/B:BIOM.0000027706.51112.62
Hu, 2012, Transgenic milk containing recombinant human lactoferrin modulates the intestinal flora in piglets, Biochem. Cell Biol., 90, 485, 10.1139/o2012-003
Sachdeva, 2014, Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: A review, World J. Gastroenterol., 20, 724, 10.3748/wjg.v20.i3.724
Vongbhavit, 2016, Prevention of necrotizing enterocolitis through manipulation of the intestinal microbiota of the premature Infant, Clin. Ther., 38, 716, 10.1016/j.clinthera.2016.01.006
Pammi, 2011, Oral lactoferrin for the treatment of sepsis and necrotizing enterocolitis in neonates, Cochrane Database Syst. Rev., 10, CD007138
Harmsen, 1995, Antiviral effects of plasma and milk proteins: Lactoferrin shows a potent activity against both human immunodeficiency virus and human cytomegalovirus replication in vitro, J. Infect. Dis., 172, 280, 10.1093/infdis/172.2.380
Andersen, 2001, Lactoferrin and cyclic lactoferricin inhibit the entry of human cytomegalovirus into human fibroblasts, Antivir. Res., 51, 141, 10.1016/S0166-3542(01)00146-2
Marchetti, 1996, Lactoferrin inhibits herpes simplex virus type 1 adsorption to Vero cells, Ativir. Res., 29, 221, 10.1016/0166-3542(95)00840-3
Marchetti, 1998, Metal complexes of bovine lactoferrin inhibit in vitro replication of herpes simplex virus type 1 and 2, Biometals, 11, 89, 10.1023/A:1009217709851
Siciliano, 1999, Bovine lactoferrin peptidic fragments involved in inhibition of herpes simplex virus type 1 infection, Biochem. Biophys. Res. Commun., 264, 19, 10.1006/bbrc.1999.1318
Swart, 1996, Antiviral effects of milk proteins: Acylation results in polyanionic compounds with potent activity against human immunodeficiency virus types 1 and 2 in vitro, AIDS Res. Human Retrov., 12, 769, 10.1089/aid.1996.12.769
Puddu, 1998, Antiviral effects of bovine lactoferrin saturated with metal ions on early steps of human immunodeficiency virus type 1 infection, Int. J. Biochem. Cell Biol., 30, 1055, 10.1016/S1357-2725(98)00066-1
Berkhout, 2004, The antiviral activity of the milk protein lactoferrin against the human immunodeficiency virus type 1, Biometals, 17, 291, 10.1023/B:BIOM.0000027707.82911.be
Ikeda, 1998, Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes, Biochem. Biophys. Res. Commun., 245, 549, 10.1006/bbrc.1998.8481
Hara, 2002, Lactoferrin inhibits hepatitis B virus infection in cultured human hepatocytes, Hepatol. Res., 24, 228, 10.1016/S1386-6346(02)00088-8
Tanaka, 1999, Lactoferrin inhibits hepatitis C virus viremia in patients with chronic hepatitis C: A pilot study, Jpn. J. Cancer Res., 90, 367, 10.1111/j.1349-7006.1999.tb00756.x
Ueno, 2006, Randomized, double-blind, placebo-controlled trial of bovine lactoferrin in patients with chronic hepatitis C, Cancer Sci., 97, 1105, 10.1111/j.1349-7006.2006.00274.x
Pietrantoni, 2010, Bovine lactoferrin inhibits influenza A virus induced programmed cell death in vitro, Biometals, 23, 465, 10.1007/s10534-010-9323-3
Wakabayashi, 2014, Lactoferrin for prevention of common viral infections, J. Infect. Chemother., 20, 666, 10.1016/j.jiac.2014.08.003
Weinberg, 1994, Iron chelators as therapeutic agents against Pneumocystis carinii, Antimicrob. Agents Chemother., 38, 997, 10.1128/AAC.38.5.997
Cirioni, 2000, Inhibition of growth of Pneumocystis carinii by lactoferrins alone and in combination with pyrimethamine, clarithromycin and minocycline, J. Antimicrob. Chemother., 46, 577, 10.1093/jac/46.4.577
Tachezy, 1996, Tritrichomonas foetus: Iron acquisition from lactoferrin and transferrin, Exp. Parasitol., 83, 216, 10.1006/expr.1996.0068
Shakibaei, 1996, Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans, J. Exp. Med., 184, 1699, 10.1084/jem.184.5.1699
Giansanti, 2013, An update on the antifungal activities of Lactoferrin: New promising applications in diagnostic, therapeutics and biotechnology, Anti-Infect. Agents, 11, 155, 10.2174/2211352511311020009
Puddu, 2009, Immunomodulatory effects of lactoferrin on antigen presenting cells, Biochimie, 91, 11, 10.1016/j.biochi.2008.05.005
Embleton, 2013, Lactoferrin: Antimicrobial activity and therapeutic potential, Semin. Fetal Neonat. Med., 18, 143, 10.1016/j.siny.2013.02.001
Legrand, 2010, A critical review of the roles of host lactoferrin in immunity, Biometals, 23, 365, 10.1007/s10534-010-9297-1
Actor, 2009, Lactoferrin as a natural immune modulator, Curr. Pharm. Des., 15, 1956, 10.2174/138161209788453202
Turin, 2014, Lactoferrin for prevention of neonatal sepsis, Biometals, 27, 1007, 10.1007/s10534-014-9754-3
Kruzel, 2007, Lactoferrin in health and disease, Postepy Hig. Med. Dosw., 61, 261
Kawasaki, 2000, Role of basic residues of human lactoferrin in the interaction with B lymphocytes, Biosci. Biotechnol. Biochem., 64, 14, 10.1271/bbb.64.314
Masson, 2000, Lactoferrin upregulates the expression of CD4 antigen through the stimulation of the mitogen- activated protein kinase in the human lymphoblastic T Jurkat cell line, J. Cell. Biochem., 79, 583, 10.1002/1097-4644(20001215)79:4<583::AID-JCB70>3.0.CO;2-9
2014, Immunomodulatory effects of lactoferrin, Acta Pharmacol. Sin., 35, 57
Legrand, 2005, Lactoferrin: A modulator of immune and inflammatory responses, Cell. Mol. Life Sci., 62, 2549, 10.1007/s00018-005-5370-2
Hwang, 2005, Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis, Int. Immunopharmacol., 5, 591, 10.1016/j.intimp.2004.11.006
Mulder, 2008, Bovine lactoferrin supplementation supports immune and antioxidant status in healthy human males, Nutr. Res., 28, 583, 10.1016/j.nutres.2008.05.007
Mayeur, 2016, Lactoferrin, a Pleiotropic Protein inHealth and Disease, Antioxid. Redox Signal., 24, 813, 10.1089/ars.2015.6458
Saraiva, 2010, The regulation of IL-10 production by immune cells, Nat. Rev. Immunol., 10, 70, 10.1038/nri2711
Liu, 2013, Natural killer cell populations and cytotoxic activity in pigs fed mother’s milk, formula, or formula supplemented with bovine lactoferrin, Pediatr. Res., 74, 402, 10.1038/pr.2013.125
Cooper, 2013, Consumption of transgenic cows’ milk containing human lactoferrin results in beneficial changes in the gastrointestinal tract and systemic health of young pigs, Transgenic. Res., 22, 571, 10.1007/s11248-012-9662-7
Yang, 2014, Lactoferrin up-regulates intestinal gene expression of brain-derived neurotrophic factors BDNF, UCHL1 and alkaline phosphatase activity to alleviate early weaning diarrhea in postnatal piglets, J. Nutr. Biochem., 25, 834, 10.1016/j.jnutbio.2014.03.015
Wu, 2014, Enteral supplementation of bovine lactoferrin improves gut barrier function in rats after massive bowel resection, Br. J. Nutr., 112, 486, 10.1017/S000711451400107X
2016, Modulatory Effects of Oral Bovine Lactoferrin on the IgA Response at Inductor and Effector Sites of Distal Small Intestine from BALB/c Mice, Arch. Immunol. Ther. Exp. (Warsz)., 64, 57, 10.1007/s00005-015-0358-6
Kawashima, M., Kawakita, T., Inaba, T., Okada, N., Ito, M., Shimmura, S., Watanabe, M., Shinmura, K., and Tsubota, K. (2012). Dietary Lactoferrin Alleviates Age-Related Lacrimal Gland Dysfunction in Mice. PLoS ONE, 7.
Kawashima, 2016, Dietary Supplementation with a Combination of Lactoferrin, Fish Oil, and Enterococcus faecium WB2000 for Treating Dry Eye: A Rat Model and Human Clinical Study, Ocul. Surf., 14, 255, 10.1016/j.jtos.2015.12.005
Cooper, 2015, Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: Past, present, and future, Transgenic Res., 24, 605, 10.1007/s11248-015-9885-5
Dia, 2010, The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells, Cancer Metastasis Rev., 29, 511, 10.1007/s10555-010-9241-4
Teng, 2004, Methylation and expression of the lactoferrin gene in human tissues and cancer cells, Biometals, 17, 317, 10.1023/B:BIOM.0000027711.13818.8a
Shaheduzzaman, 2007, Silencing of Lactotransferrin expression by methylation in prostate cancer progression, Cancer Biol. Ther., 6, 1088, 10.4161/cbt.6.7.4327
Wang, 2011, Effects of adenovirus vectors mediated human lactoferrin cDNA on mice bearing EMT6 breast carcinoma, Die Pharm., 66, 704
Li, 2011, Growth suppression effects of recombinant adenovirus expressing human lactoferrin on cervical cancer in vitro and in vivo, Cancer Biother. Radiopharm., 26, 477
Freiburgahus, 2009, Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line, J. Dairy Sci., 92, 2477, 10.3168/jds.2008-1851
Jiang, 2011, Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities, J. Pediatr. Gastroenterol. Nutr., 53, 606, 10.1097/MPG.0b013e318230a419
Kuhara, 2000, Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium, Nutr. Cancer, 38, 192, 10.1207/S15327914NC382_8
Iigo, 2004, Orally Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: A possible explanation for inhibition of carcinogenesis and metastasis, Cytokine, 25, 36, 10.1016/j.cyto.2003.09.009
Pan, 2013, Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage, J. Dairy Sci., 96, 7511, 10.3168/jds.2013-7285
Deng, 2013, Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms, Oncogene, 32, 4273, 10.1038/onc.2012.434
Letchoumy, 2008, In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation, DNA damage, proliferation, invasion, and angiogenesis during experimental oral carcinogenesis, Oncol. Res., 17, 193, 10.3727/096504008786111365
Wolf, 2007, Oral lactoferrin results in T cell-dependent tumor inhibition of head and neck squamous cell carcinoma in vivo, Clin. Cancer Res., 13, 1601, 10.1158/1078-0432.CCR-06-2008
Xiao, 2004, Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells, Clin. Cancer Res., 10, 8683, 10.1158/1078-0432.CCR-04-0988
Sakai, 2005, Pepsin-digested lactoferrin induces apoptotic cell death with JNK/SAPK activation in oral cancer cells, J. Pharm. Sci., 98, 41, 10.1254/jphs.FPJ04047X
Richardosn, 2009, Intracellular delivery of bovine lactoferricin’s antimicrobial core (RRWQWR) kills T-leukemia cells, Biochem. Biophys. Res. Commun., 388, 736, 10.1016/j.bbrc.2009.08.083
Mader, 2005, Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines, Mol. Cancer Ther., 4, 612, 10.1158/1535-7163.MCT-04-0077
Lu, 2016, PFR peptide, one of the antimicrobial peptides identified from the derivatives of lactoferrin, induces necrosis inleukemia cells, Sci. Rep., 6, 20823, 10.1038/srep20823
Lee, 2010, E2F1-directed activation of Bcl-2 is correlated with lactoferrin-induced apoptosis in Jurkat leukemia T lymphocytes, Biometals, 23, 507, 10.1007/s10534-010-9341-1
Matsuda, 2007, Post-initiation chemopreventive effects of dietary bovine lactoferrin on 4-(methynitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice, Cancer Lett., 246, 41, 10.1016/j.canlet.2006.01.034
Son, 2006, Human lactoferrin controls the level of retinoblastoma protein and its activity, Biochem. Cell Biol., 84, 345, 10.1139/o06-048
Wang, 2015, The effect of Lfcin-B on non-small cell lung cancer H460 cells is mediated by inhibiting VEGF expression and inducing apoptosis, Arch. Pharm. Res., 38, 261, 10.1007/s12272-014-0373-x
Eliassen, 2006, The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo, Int. J. Cancer, 119, 493, 10.1002/ijc.21886
Arcella, 2015, In vitro and in vivo effect of human lactoferrin on glioblastoma growth, J. Neurosurg., 123, 1026, 10.3171/2014.12.JNS14512
Hoedt, 2010, Discrimination and evaluation of lactoferrin and delta-lactoferrin gene expression levels in cancer cells and under inflammatory stimuli using TaqMan real-time PCR, Biometals, 23, 441, 10.1007/s10534-010-9305-5
Peyrat, 2005, Expression and prognostic value of lactoferrin mRNA isoforms in human breast cancer, Int. J. Cancer, 114, 299, 10.1002/ijc.20728
Kanwar, 2008, ‘Iron-saturated’ lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy, Immunol. Cell Boil., 86, 277, 10.1038/sj.icb.7100163
Kanwar, 2012, Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocar-riers for oral delivery in colon cancer therapy, Nanomedicine, 7, 1521, 10.2217/nnm.12.29
Tsuda, 2010, Cancer prevention by bovine lactoferrin: From animal studies to human trial, Biometals, 23, 399, 10.1007/s10534-010-9331-3
Furlong, 2006, Lactoferricin-induced apoptosis in estrogen- nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen, Oncol. Rep., 15, 1385
Massodi, 2009, Application of thermally responsive elastin-like polypeptide fused to a lactoferrin-derived peptide for treatment of pancreatic cancer, Molecules, 14, 1999, 10.3390/molecules14061999
Roseanu, 2010, Liposomalization of lactoferrin enhanced its anti-tumoral effects on melanoma cells, Biometals, 23, 485, 10.1007/s10534-010-9312-6
Artym, 2004, Effect of lactoferrin on the methotrexate- induced suppression of the cellular and humoral immune response in mice, Anticancer Res., 24, 3831
Artym, 2005, Lactoferrin accelerates reconstitution of the humoral and cellular immune response during chemotherapy-induced immunosuppression and bone marrow transplant in mice, Stem. Cells Dev., 14, 548, 10.1089/scd.2005.14.548
Sun, X., Jiang, R., Przepiorski, A., Reddy, S., Palmano, K.P., and Krissansen, G.W. (2012). “Iron-saturated” bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice. BMC Cancer, 12.
Guo, 2009, Orally administered lactoferrin preserves bone mass and microarchitecture in ovariectomized rats, J. Nutr., 139, 958, 10.3945/jn.108.100586
Bharadwaj, 2009, Milk ribonuclease-enriched lactoferrin induces positive effects on bone turnover markers in postmenopausal women, Osteoporos. Int., 20, 1603, 10.1007/s00198-009-0839-8
Cornish, 2010, Lactoferrin as an effector molecule in the skeleton, Biometals, 23, 425, 10.1007/s10534-010-9320-6
Georgieff, 2008, The role of iron in neurodevelopment: Fetal iron deficiency and the developing hippocampus, Biochem. Soc. Trans., 36, 267, 10.1042/BST0361267
Somm, 2014, Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism, Pediatr. Res., 75, 51, 10.1038/pr.2013.199
Szwajkowska, 2011, Bovine milk proteins as the source of bioactive peptides influencing the consumers’ immune system, Anim. Sci. Pap. Rep., 29, 269
Brouwer, 2008, Various routes of administration of (99m) Tc-labeled synthetic lactoferrin antimicrobial peptide hLF 1–11 enables monitoring and effective killing of multidrug-resistant Staphylococcus aureus infections in mice, Peptides, 29, 1109, 10.1016/j.peptides.2008.03.003
Gifford, 2005, Lactoferricin: A lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties, Cell Mol. Life Sci., 62, 2588, 10.1007/s00018-005-5373-z
Nazmi, 2010, Bactericidal effect of bovine lactoferrin, LFcin, LFampin and LFchimera on antibiotic-resistant Staphylococcus aureus and Escherichia coli, Biometals, 23, 569, 10.1007/s10534-010-9306-4
Wakabayashi, 1992, Inactivation of Listeria monocytogenes by lactoferricin, a potent antimicrobial peptide derived from cow’s milk, J. Food Prot., 55, 238, 10.4315/0362-028X-55.4.238
Dijkshoorn, 2004, The synthetic N-terminal peptide of human lactoferrin, hLF(1–11), is highly effective against experimental infection caused by multidrug-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 48, 4919, 10.1128/AAC.48.12.4919-4921.2004
Federico, 2015, Efficacy of lactoferricin B in controlling ready-to-eat vegetable spoilage caused by Pseudomonas spp., Int. J. Food Microbiol., 215, 179, 10.1016/j.ijfoodmicro.2015.09.017
Sánchez-Gómez, S., Ferrer-Espada, R., Stewart, P.S., Pitts, B., Lohner, K., and Martínez de Tejada, G. (2015). Antimicrobial activity of synthetic cationic peptides and lipopeptides derived from human lactoferricin against Pseudomonas aeruginosa planktonic cultures and biofilms. BMC Microbiol., 15.
2015, Antibacterial activity of synthetic peptides derived from lactoferricin against Escherichia coli ATCC 25922 and Enterococcus faecalis ATCC 29212, Biomed. Res. Int., 2015, 453826
Tang, 2010, High-level expression, purification and antibacterial activity of bovine lactoferricin and lactoferrampin in Photorhabdus luminescens, Protein Expr. Purif., 73, 132, 10.1016/j.pep.2010.05.013
Cruz, 2014, Design and activity of novel lactoferrampin analogues against O157:H7 enterohemorrhagic Escherichia coli, Biopolymers, 101, 319, 10.1002/bip.22360
Nazmi, 2006, Distinct bactericidal activities of bovine lactoferrin peptides LFampin 268–284 and LFampin 265–284: Asp-Leu-Ile makes a difference, Biochem. Cell. Biol., 84, 358, 10.1139/o06-042
Wang, 2016, Bovine Lactoferrampin, Human Lactoferricin, and Lactoferrin 1–11 Inhibit Nuclear Translocation of HIV Integrase, Appl. Biochem. Biotechnol., 179, 1202, 10.1007/s12010-016-2059-y
Ng, 2015, Antiviral activities of whey proteins, Appl. Microbiol. Biotechnol., 99, 6997, 10.1007/s00253-015-6818-4
Tsou, 2014, Investigation of anti-infection mechanism of lactoferricin and splunc-1, Evid. Based Complement. Alternat. Med., 2014, 907028, 10.1155/2014/907028
Jenssen, 2008, Inhibition of HSV cell-to-cell spread by lactoferrin and lactoferricin, Antivir. Res., 79, 192, 10.1016/j.antiviral.2008.03.004
Mistry, 2007, The anti-papillomavirus activity of human and bovine lactoferricin, Antivir. Res., 75, 258, 10.1016/j.antiviral.2007.03.012
Lupetti, 2007, Human lactoferrin-derived peptide’s antifungal activities against disseminated Candida albicans infection, J. Infect. Dis., 196, 1416, 10.1086/522427
Sengupta, 2012, Effects of lactoferricin Bagainst keratitis-associated fungal biofilms, J. Infect. Chemother., 18, 698, 10.1007/s10156-012-0398-3
Vylkova, 2007, The role of released ATP in killing Candida albicans and other extracellular microbial pathogens by cationic peptides, Purinergic Signal., 3, 91, 10.1007/s11302-006-9040-0
Tang, 2012, Dietary supplementation with bovine lactoferrampin-lactoferricin produced by Pichia pastoris fed-batch fermentation affects intestinal microflora in weaned piglets, Appl. Biochem. Biotechnol., 168, 887, 10.1007/s12010-012-9827-0
Haney, 2009, Novel lactoferrampin antimicrobial peptides derived from human lactoferrin, Biochimie, 91, 141, 10.1016/j.biochi.2008.04.013
Leitch, 2009, A role for antimicrobial peptides in intestinal microsporidiosis, Parasitology, 136, 175, 10.1017/S0031182008005313
Nazmi, 2010, Microbicidal effect of the lactoferrin peptides lactoferricin17–30, lactoferrampin265–284, and lactoferrin chimera on the parasite Entamoeba histolytica, Biometals, 23, 563, 10.1007/s10534-010-9295-3
Eliassen, 2002, Evidence for a direct antitumor mechanism of action of bovine lactoferricin, Anticancer Res., 22, 2703
Chen, 2014, Potential clinical applications of multi-functional milk proteins and peptides in cancer management, Curr. Med. Chem., 21, 2424, 10.2174/0929867321666140205135739
Yin, 2013, Studies on anticancer activities of lactoferrin and lactoferricin, Curr. Protein Pept. Sci., 14, 492, 10.2174/13892037113149990066
Zheng, 2012, New function of lactoferrin: Protection against cancer development and metastasis, Zhong Nan Da Xue Xue Bao Yi Xue Ban, 37, 1284