Molecular Nutrition and Food Research
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Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop
Molecular Nutrition and Food Research - Tập 63 Số 6 - 2019
ScopeAlcoholic liver disease (ALD) is a major cause of morbidity and mortality
worldwide. Oxidative stress induced during the alcohol metabolism plays a
crucial role in ALD, and clinical evidence demonstrates the prevalence and risks
of vitamin D (VD) deficiency in ALD. This study aims to explore the mechanism of
VD administration to ameliorate alcohol‐induced cell injury.Methods and
resultsVD act...
Acteoside inhibits PMA‐induced matrix metalloproteinase‐9 expression via CaMK/ERK‐ and JNK/NF‐κB‐dependent signaling
Molecular Nutrition and Food Research - Tập 55 Số S1 - 2011
AbstractScope: Acteoside, an active phenylethanoid glycoside found in bitter tea
and many medicinal plants, displays chemopreventive properties. The aim of our
study was to determine the effect of acteoside on tumor invasion and migration;
the possible mechanisms involved in this inhibition were investigated in human
fibrosarcoma HT‐1080 cells.Methods and results: We employed invasion, migration
a...
Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet‐induced obese mice
Molecular Nutrition and Food Research - Tập 60 Số 3 - Trang 687-694 - 2016
ScopeThis study aimed to determine whether cherry anthocyanin (CA) and mulberry
anthocyanin (MA) can alleviate oxidative stress and inflammation associated with
developing obesity in mice fed with high‐fat diet (HFD).Methods and resultsCA
and MA were added in the daily food of mice throughout the experiment. Sixty
mice were randomly divided into two groups: a low‐fat diet (LFD, n = 12) group
and H...
Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications
Molecular Nutrition and Food Research - Tập 63 Số 4 - 2019
ScopeThe gut microbiota ellagitannin‐metabolizing phenotypes (i.e., urolithin
metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk
biomarkers because the host blood lipid profile is reported to be associated
with specific UMs. However, the link for this association remains unknown so
far.Methods and ResultsThe gut microbiome of 249 healthy individuals is analyzed
using 16...
Isothiocyanate‐rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice
Molecular Nutrition and Food Research - Tập 59 Số 6 - Trang 1013-1024 - 2015
ScopeMoringa oleifera (moringa) is tropical plant traditionally used as an
antidiabetic food. It produces structurally unique and chemically stable moringa
isothiocyanates (MICs) that were evaluated for their therapeutic use in
vivo.Methods and resultsC57BL/6L mice fed very high fat diet (VHFD) supplemented
with 5% moringa concentrate (MC, delivering 66 mg/kg/d of MICs) accumulated fat
mass, had i...
Possible effects of dietary polyphenols on sugar absorption and digestion
Molecular Nutrition and Food Research - Tập 57 Số 1 - Trang 48-57 - 2013
Excessive post‐prandial glucose excursions are a risk factor for developing
diabetes, associated with impaired glucose tolerance. One way to limit the
excursion is to inhibit the activity of digestive enzymes for glucose production
and of the transporters responsible for glucose absorption. Flavonols,
theaflavins, gallate esters, 5‐caffeoylqunic acid and proanthocyanidins inhibit
α‐amylase activit...
Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice
Molecular Nutrition and Food Research - Tập 53 Số 7 - Trang 859-868 - 2009
AbstractQuercetin is a food component that may ameliorate the diabetic symptoms.
We examined hepatic gene expression of BALB/c mice with streptozotocin
(STZ)‐induced diabetes to elucidate the mechanism of the protective effect of
dietary quercetin on diabetes‐associated liver injury. We fed normal and
STZ‐induced diabetic mice with diets containing quercetin for 2 wk and compared
the patterns of h...
Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential
Molecular Nutrition and Food Research - Tập 57 Số 1 - Trang 114-125 - 2013
Diabetes has emerged as a major threat to worldwide health. The exact mechanisms
underlying the disease are unknown; however, there is growing evidence that the
excess generation of reactive oxygen species (ROS) associated with
hyperglycemia, causes oxidative stress in a variety of tissues. In this context,
various natural compounds with pleiotropic actions like α‐lipoic acid (LA) are
of interest,...
Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator‐activated receptor‐α (PPAR ‐α) activation in diabetic obese mice
Molecular Nutrition and Food Research - Tập 57 Số 7 - Trang 1295-1299 - 2013
Dill, a small annual herb, is widely used as a flavoring agent in dishes
including salads. It has been demonstrated that dill extract and its essential
oil show hypolipidemic effects in rats. However, the mechanism of these effects
has not been elucidated yet. We found that dill seed extract (DSE) activated
peroxisome proliferator‐activated receptor‐α (PPAR‐α), an indispensable
regulator for hepat...
Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland
Molecular Nutrition and Food Research - Tập 60 Số 2 - Trang 369-380 - 2016
ScopeWe studied the impact of dietary supplementation with licorice root
components on diet‐induced obesity, fat accumulation, and hepatic steatosis in
ovariectomized C57BL/6 mice as a menopause model.Materials and methodsWe
evaluated the molecular and physiological effects of dietary licorice root
administered to ovariectomized C57BL/6 mice as root powder (LRP), extracts
(LRE), or isolated isoliq...
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