Molecular Nutrition and Food Research

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Vitamin D Protects Against Alcohol‐Induced Liver Cell Injury Within an NRF2–ALDH2 Feedback Loop
Molecular Nutrition and Food Research - Tập 63 Số 6 - 2019
Hong Zhang, Lian Xue, Bingyan Li, Zengli Zhang, Shasha Tao
ScopeAlcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Oxidative stress induced during the alcohol metabolism plays a crucial role in ALD, and clinical evidence demonstrates the prevalence and risks of vitamin D (VD) deficiency in ALD. This study aims to explore the mechanism of VD administration to ameliorate alcohol‐in...... hiện toàn bộ
Acteoside inhibits PMA‐induced matrix metalloproteinase‐9 expression via CaMK/ERK‐ and JNK/NF‐κB‐dependent signaling
Molecular Nutrition and Food Research - Tập 55 Số S1 - 2011
Yong Pil Hwang, Hyung Gyun Kim, Jae Ho Choi, Bong Hwan Park, Myung Ho Jeong, Tae Cheon Jeong, Hye Gwang Jeong
AbstractScope: Acteoside, an active phenylethanoid glycoside found in bitter tea and many medicinal plants, displays chemopreventive properties. The aim of our study was to determine the effect of acteoside on tumor invasion and migration; the possible mechanisms involved in this inhibition were investigated in human fibrosarcoma HT‐1080 cell...... hiện toàn bộ
Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet‐induced obese mice
Molecular Nutrition and Food Research - Tập 60 Số 3 - Trang 687-694 - 2016
Tao Wu, Jinjin Yin, Guohua Zhang, Hairong Long, Xiaodong Zheng
ScopeThis study aimed to determine whether cherry anthocyanin (CA) and mulberry anthocyanin (MA) can alleviate oxidative stress and inflammation associated with developing obesity in mice fed with high‐fat diet (HFD).Methods and resultsCA and MA were added in the daily food of mice throughout ...... hiện toàn bộ
Deciphering the Human Gut Microbiome of Urolithin Metabotypes: Association with Enterotypes and Potential Cardiometabolic Health Implications
Molecular Nutrition and Food Research - Tập 63 Số 4 - 2019
María Romo‐Vaquero, Adrián Cortés‐Martín, Viviana Loria‐Kohen, Ana Ramírez de Molina, Izaskun García‐Mantrana, María Carmen Collado, Juan Carlos Espı́n, María V. Selma
ScopeThe gut microbiota ellagitannin‐metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. However, the link for this association remains unknown so far....... hiện toàn bộ
Isothiocyanate‐rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice
Molecular Nutrition and Food Research - Tập 59 Số 6 - Trang 1013-1024 - 2015
Carrie Waterman, Patricio Rojas‐Silva, Tugba Boyunegmez Tumer, Peter Kühn, Allison J. Richard, Shawna Wicks, Jacqueline M. Stephens, Zhong Wang, Randy Mynatt, William T. Cefalu, Ilya Raskin
ScopeMoringa oleifera (moringa) is tropical plant traditionally used as an antidiabetic food. It produces structurally unique and chemically stable moringa isothiocyanates (MICs) that were evaluated for their therapeutic use in vivo.Methods and resultsC57BL/6L mice f...... hiện toàn bộ
Possible effects of dietary polyphenols on sugar absorption and digestion
Molecular Nutrition and Food Research - Tập 57 Số 1 - Trang 48-57 - 2013
Gary Williamson
Excessive post‐prandial glucose excursions are a risk factor for developing diabetes, associated with impaired glucose tolerance. One way to limit the excursion is to inhibit the activity of digestive enzymes for glucose production and of the transporters responsible for glucose absorption. Flavonols, theaflavins, gallate esters, 5‐caffeoylqunic acid and proanthocyanidins inhibit α‐amylase...... hiện toàn bộ
Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice
Molecular Nutrition and Food Research - Tập 53 Số 7 - Trang 859-868 - 2009
Msauko Kobori, Saeko Masumoto, Yukari Akimoto, Yumiko Takahashi
AbstractQuercetin is a food component that may ameliorate the diabetic symptoms. We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)‐induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes‐associated liver injury. We fed normal and STZ‐induced diabetic mice with diets containing quercetin for 2 ...... hiện toàn bộ
Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential
Molecular Nutrition and Food Research - Tập 57 Số 1 - Trang 114-125 - 2013
Luc Rochette, Stéliana Ghibu, Carole Richard, Marianne Zeller, Yves Cottin, Catherine Vergely
Diabetes has emerged as a major threat to worldwide health. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that the excess generation of reactive oxygen species (ROS) associated with hyperglycemia, causes oxidative stress in a variety of tissues. In this context, various natural compo...... hiện toàn bộ
Dill seed extract improves abnormalities in lipid metabolism through peroxisome proliferator‐activated receptor‐α (PPAR‐α) activation in diabetic obese mice
Molecular Nutrition and Food Research - Tập 57 Số 7 - Trang 1295-1299 - 2013
Nobuyuki Takahashi, Lan Yao, Minji Kim, Hiroshi Sasako, Morihiro Aoyagi, Jinji Shono, Nobuaki Tsuge, Tsuyoshi Goto, Teruo Kawada
Dill, a small annual herb, is widely used as a flavoring agent in dishes including salads. It has been demonstrated that dill extract and its essential oil show hypolipidemic effects in rats. However, the mechanism of these effects has not been elucidated yet. We found that dill seed extract (DSE) activated peroxisome proliferat...... hiện toàn bộ
Dietary licorice root supplementation reduces diet‐induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland
Molecular Nutrition and Food Research - Tập 60 Số 2 - Trang 369-380 - 2016
Zeynep Madak‐Erdogan, Ping Gong, Yiru Zhao, Liwen Xu, Kinga Wrobel, James A. Hartman, Michelle Wang, Anthony Cam, Urszula T. Iwaniec, Russell T. Turner, Nathan C. Twaddle, Daniel R. Doerge, Ikhlas A. Khan, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William G. Helferich
ScopeWe studied the impact of dietary supplementation with licorice root components on diet‐induced obesity, fat accumulation, and hepatic steatosis in ovariectomized C57BL/6 mice as a menopause model.Materials and methodsWe evaluated the molecular and physiological effects of dietary licorice...... hiện toàn bộ
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