Direct and indirect antioxidant properties of α‐lipoic acid and therapeutic potential

Molecular Nutrition and Food Research - Tập 57 Số 1 - Trang 114-125 - 2013
Luc Rochette1, Stéliana Ghibu2, Carole Richard1,3, Marianne Zeller1, Yves Cottin1,3, Catherine Vergely1
1INSERM UMR866 Laboratoire de Physiopathologie et Pharmacologie Cardio‐Métaboliques Université de Bourgogne Facultés de Médecine et Pharmacie Dijon France
2Department of Pharmacology, Physiology and Physiopathology, Faculty of Pharmacy, University of Medicine and Pharmacy, Cluj-Napoca, Romania
3Service des Soins Intensifs de Cardiologie CHU Bocage Dijon France

Tóm tắt

Diabetes has emerged as a major threat to worldwide health. The exact mechanisms underlying the disease are unknown; however, there is growing evidence that the excess generation of reactive oxygen species (ROS) associated with hyperglycemia, causes oxidative stress in a variety of tissues. In this context, various natural compounds with pleiotropic actions like α‐lipoic acid (LA) are of interest, especially in metabolic diseases such as diabetes. LA, either as a dietary supplement or a therapeutic agent, modulates redox potential because of its ability to match the redox status between different subcellular compartments as well as extracellularly. Both the oxidized (disulfide) and reduced (di‐thiol: dihydro‐lipoic acid, DHLA) forms of LA show antioxidant properties. LA exerts antioxidant effects in biological systems through ROS quenching but also via an action on transition metal chelation. Dietary supplementation with LA has been successfully employed in a variety of in vivo models of disease associated with an imbalance of redox status: diabetes and cardiovascular diseases. The complex and intimate association between increased oxidative stress and increased inflammation in related disorders such as diabetes, makes it difficult to establish the temporal sequence of the relationship.

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Thông tin xuất bản

Molecular Nutrition and Food Research

Tập 57 Số 1

114-125

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