Mediators of Inflammation
SCIE-ISI SCOPUS (1992-2023)
0962-9351
1466-1861
Mỹ
Cơ quản chủ quản: Hindawi Publishing Corporation , HINDAWI LTD
Lĩnh vực:
ImmunologyCell Biology
Các bài báo tiêu biểu
Understanding the Mysterious M2 Macrophage through Activation Markers and Effector MechanismsThe alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers. These markers are transmembrane glycoproteins, scavenger receptors, enzymes, growth... ... hiện toàn bộ
Tập 2015 Số 1 - 2015
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated ViewSepsis and septic shock are among the leading causes of death in intensive care units worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines are important pleiotropic regulators of the immune response, which have a crucial role in the complex pathophysiology underl... ... hiện toàn bộ
Tập 2013 - Trang 1-16 - 2013
LOX-1, OxLDL, and AtherosclerosisOxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effec... ... hiện toàn bộ
Tập 2013 - Trang 1-12 - 2013
Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and AtherosclerosisType 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic -cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate -cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In additi... ... hiện toàn bộ
Tập 2010 - Trang 1-11 - 2010
Apocynin: Molecular AptitudesApocynin is a naturally occurring methoxy‐substituted catechol, experimentally used as an inhibitor of NADPH‐oxidase. It can decrease the production of superoxide () from activated neutrophils and macrophages while the ability of phagocytosis remains unaffected. The anti‐inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation. Apocynin... ... hiện toàn bộ
Tập 2008 Số 1 - 2008
Therapeutic Effects of Quercetin on Inflammation, Obesity, and Type 2 DiabetesIn previous studies, abdominal obesity has been related to total low-grade inflammation and in some cases has resulted in insulin resistance and other metabolism related disorders such as diabetes. Quercetin is a polyphenol, which is a derivative of plants, and has been shownin vitro as well as in a few animal models to have several potential anti-inflammatory as ... ... hiện toàn bộ
Tập 2016 - Trang 1-5 - 2016
Scorpion Venom and the Inflammatory ResponseScorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims of envenoming by a scorpion suffer a variety of pathologies, involving mai... ... hiện toàn bộ
Tập 2010 - Trang 1-16 - 2010
Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-InducedPGE 2 Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA. Leptin is an adipokine regulating energy balance, and it has recently been related also to arthritis and inflammation as a proinflammatory factor. In the present paper, the effects of leptin... ... hiện toàn bộ
Tập 2009 - Trang 1-10 - 2009
Inflammation and Immune Response in COPD: Where Do We Stand?Increasing evidence indicates that chronic inflammatory and immune responses play key roles in the development and progression of COPD. Recent data provide evidence for a role in the NLRP3 inflammasome in the airway inflammation observed in COPD. Cigarette smoke activates innate immune cells by triggering pattern recognition receptors (PRRs) to release “danger signal”. These signals act as... ... hiện toàn bộ
Tập 2013 - Trang 1-9 - 2013
Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 TreatmentCOVID-19 is a pandemic disease caused by the new coronavirus SARS-CoV-2 that mostly affects the respiratory system. The consequent inflammation is not able to clear viruses. The persistent excessive inflammatory response can build up a clinical picture that is very difficult to manage and potentially fatal. Modulating the immune response plays a key role in fighting the disease. One of the... ... hiện toàn bộ
Tập 2020 - Trang 1-25 - 2020