Apocynin: Molecular Aptitudes
Tóm tắt
Apocynin is a naturally occurring methoxy‐substituted catechol, experimentally used as an inhibitor of NADPH‐oxidase. It can decrease the production of superoxide () from activated neutrophils and macrophages while the ability of phagocytosis remains unaffected. The anti‐inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation. Apocynin, after metabolic conversion, inhibits the assembly of NADPH‐oxidase that is responsible for reactive oxygen species (ROS) production. It is, therefore, extensively used to reveal the role of this enzyme in cell and experimental models. Although some of the ROS serve as signaling molecules in the cells, excessive production is damaging and has been implicated to play an important role in the progression of many disease processes. This is why in many studies apocynin presents a promising potential treatment for some disorders; however, its utility with inflammatory diseases remains to be determined. Since its mode of action is not well defined, we tried to get a more precise insight into the mechanisms by which apocynin exerts its activity. Considering the anti‐inflammatory activities of apocynin, we may conclude that this compound definitely deserves further study.
Từ khóa
Tài liệu tham khảo
Gajewska Z. G., 1981, Analysis of an industrial smoke preparation, Bromatologia i Chemia Toksykologiczna, 14, 3
Pearse D. B., 1993, Edema clearance in isolated sheep lungs, Journal of Applied Physiology, 74, 126, 10.1152/jappl.1993.74.1.126
Nishikawa M., 1996, Role of superoxide anions in airway hyperresponsiveness induced by cigarette smoke in conscious guinea pigs, Lung, 174, 279, 10.1007/BF00176187
HollandJ. A. Prevention of atherosclerosis using NADPH oxidase inhibitors US patent no. 5902831 1999.
Jin L., 2006, Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats, Journal of Physiology and Pharmacology, 57, 343
′t Hart B. A., 1991, The newly developed neutrophil oxidative burst antagonist apocynin inhibits joint-swelling in rat collagen arthritis, Agents and Actions Supplements, 32, 179
Bradley J. D., 1992, Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic, Journal of Rheumatology, 19, 1950