Mediators of Inflammation
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Long Noncoding RNAs in Metabolic Syndrome Related Disorders
Mediators of Inflammation - Tập 2016 - Trang 1-12 - 2016
Ribonucleic acids (RNAs) are very complex and their all functions have yet to be
fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes)
comprise 67% of all genes and they are represented by housekeeping noncoding
RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and
small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes and
by reg...
LOX-1, OxLDL, and Atherosclerosis
Mediators of Inflammation - Tập 2013 - Trang 1-12 - 2013
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic
plaque formation and progression by several mechanisms, including the induction
of endothelial cell activation and dysfunction, macrophage foam cell formation,
and smooth muscle cell migration and proliferation. Vascular wall cells express
on their surface several scavenger receptors that mediate the cellular effects
of Ox...
Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells
Mediators of Inflammation - Tập 2020 - Trang 1-10 - 2020
Current studies have identified the multifaceted protective functions of
dexmedetomidine on multiple organs. For the first time, we clarify effects of
dexmedetomidine on monocyte-endothelial adherence and whether its underlying
mechanism is relative to connexin43 (Cx43), a key factor regulating
monocyte-endothelial adherence. U937 monocytes and human umbilical vein
endothelial cells (HUVECs) were ...
Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury
Mediators of Inflammation - Tập 2016 - Trang 1-21 - 2016
Spinal cord injury results in a life-disrupting series of deleterious
interconnected mechanisms encompassed by the primary and secondary injury. These
events are mediated by the upregulation of genes with roles in inflammation,
transcription, and signaling proteins. In particular, cytokines and growth
factors are signaling proteins that have important roles in the pathophysiology
of SCI. The balan...
Effect of platelet‐activating factor on the growth of human erythroid and myeloid CD34+ progenitors
Mediators of Inflammation - Tập 7 Số 2 - Trang 99-103 - 1998
We have assessed the effect of platelet‐activating factor (PAF), a biologically
active phospholipid present in the human marrow, on the growth of human marrow
and blood CD34+ progenitors. While the metabolization rate of PAF by CD34+ cells
is low (weak acetylhydrolase and acylation processes) it is readily catabolized
by the acetylhydrolase activity present in the growth medium (10% fetal calf
ser...
Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine
Mediators of Inflammation - Tập 2013 - Trang 1-8 - 2013
Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells
Mediators of Inflammation - Tập 2009 - Trang 1-11 - 2009
Cathepsin G is a serine protease secreted by activated neutrophils that play a
role in the inflammatory response. Because neutrophils are known to be invading
leukocytes in various tumors, their products may influence the characteristics
of tumor cells such as the growth state, motility, and the adhesiveness between
cells or the extracellular matrix. Here, we demonstrate that cathepsin G induces
c...
Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation
Mediators of Inflammation - Tập 2012 - Trang 1-13 - 2012
Neutrophils often invade various tumor tissues and affect tumor progression and
metastasis. Cathepsin G (CG) is a serine protease secreted from activated
neutrophils. Previously, we have shown that CG induces the formation of
E-cadherin-mediated multicellular spheroids of human breast cancer MCF-7 cells;
however, the molecular mechanisms involved in this process are unknown. In this
study, we inve...
Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism
Mediators of Inflammation - Tập 2014 - Trang 1-12 - 2014
We previously found that a neutrophil serine protease, cathepsin G, weakens
adherence to culture substrates and induces E-cadherin-dependent aggregation of
MCF-7 human breast cancer cells through its protease activity. In this study, we
examined whether aggregation is caused by degradation of adhesion molecules on
the culture substrates or through an unidentified mechanism. We compared the
effect ...
Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies
Mediators of Inflammation - Tập 2016 - Trang 1-10 - 2016
Huntington’s disease (HD) is a neurodegenerative disorder characterized by
selective loss of neurons in the striatum and cortex, which leads to progressive
motor dysfunction, cognitive decline, and psychiatric disorders. Although the
cause of HD is well described—HD is a genetic disorder caused by a trinucleotide
(CAG) repeat expansion in the gene encoding for huntingtin (HTT) on chromosome
4p16.3...
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