Mediators of Inflammation

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Long Noncoding RNAs in Metabolic Syndrome Related Disorders
Mediators of Inflammation - Tập 2016 - Trang 1-12 - 2016
Magdalena Łośko, Jerzy Kotlinowski, Jolanta Jura
Ribonucleic acids (RNAs) are very complex and their all functions have yet to be fully clarified. Noncoding genes (noncoding RNA, sequences, and pseudogenes) comprise 67% of all genes and they are represented by housekeeping noncoding RNAs (transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), and small nucleolar RNA (snoRNA)) that are engaged in basic cellular processes an...... hiện toàn bộ
LOX-1, OxLDL, and Atherosclerosis
Mediators of Inflammation - Tập 2013 - Trang 1-12 - 2013
Angela Pirillo, Giuseppe Danilo Norata, Alberico L. Catapano
Oxidized low-density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation and progression by several mechanisms, including the induction of endothelial cell activation and dysfunction, macrophage foam cell formation, and smooth muscle cell migration and proliferation. Vascular wall cells express on their surface several scavenger receptors that mediate the cellular effec...... hiện toàn bộ
Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells
Mediators of Inflammation - Tập 2020 - Trang 1-10 - 2020
Yunfei Chai, Runying Yu, Yong Liu, Sheng Wang, Dongdong Yuan, Jimei Chen
Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial adherence. U937 monocytes and human umbilical vein endothelial cells (HUVEC...... hiện toàn bộ
Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury
Mediators of Inflammation - Tập 2016 - Trang 1-21 - 2016
Elisa García, Jorge Aguilar-Cevallos, Raúl Silva‐García, Antonio Ibarra
Spinal cord injury results in a life-disrupting series of deleterious interconnected mechanisms encompassed by the primary and secondary injury. These events are mediated by the upregulation of genes with roles in inflammation, transcription, and signaling proteins. In particular, cytokines and growth factors are signaling proteins that have important roles in the pathophysiology of SCI. T...... hiện toàn bộ
Effect of platelet‐activating factor on the growth of human erythroid and myeloid CD34+ progenitors
Mediators of Inflammation - Tập 7 Số 2 - Trang 99-103 - 1998
F. Dupuis, Nathalie Gachard, A Allegraud, C. Dulery, Vincent Praloran, Yves Denizot
We have assessed the effect of platelet‐activating factor (PAF), a biologically active phospholipid present in the human marrow, on the growth of human marrow and blood CD34+ progenitors. While the metabolization rate of PAF by CD34+ cells is low (weak acetylhydrolase and acylation processes) it is readily catabolized by the acetylhydrolase activit...... hiện toàn bộ
Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine
Mediators of Inflammation - Tập 2013 - Trang 1-8 - 2013
Hala O. El‐Mesallamy, Nadia Μ. Hamdy, Adel El-Etriby, Eman F. Wasfey
Cathepsin G, a Neutrophil Protease, Induces Compact Cell-Cell Adhesion in MCF-7 Human Breast Cancer Cells
Mediators of Inflammation - Tập 2009 - Trang 1-11 - 2009
Tomoya Kudo, Hideaki Kigoshi, Takashi Hagiwara, Takahisa Takino, Masatoshi Yamazaki, Satoru Yui
Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between cells or the extracellular matrix. Here, we demonstrate that cathepsin G i...... hiện toàn bộ
Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation
Mediators of Inflammation - Tập 2012 - Trang 1-13 - 2012
Riyo Morimoto‐Kamata, Sei-ichiro Mizoguchi, Takeo Ichisugi, Satoru Yui
Neutrophils often invade various tumor tissues and affect tumor progression and metastasis. Cathepsin G (CG) is a serine protease secreted from activated neutrophils. Previously, we have shown that CG induces the formation of E-cadherin-mediated multicellular spheroids of human breast cancer MCF-7 cells; however, the molecular mechanisms involved in this process are unknown. In this study,...... hiện toàn bộ
Neutrophil Cathepsin G, but Not Elastase, Induces Aggregation of MCF-7 Mammary Carcinoma Cells by a Protease Activity-Dependent Cell-Oriented Mechanism
Mediators of Inflammation - Tập 2014 - Trang 1-12 - 2014
Satoru Yui, Yuuki Osawa, Takeo Ichisugi, Riyo Morimoto‐Kamata
We previously found that a neutrophil serine protease, cathepsin G, weakens adherence to culture substrates and induces E-cadherin-dependent aggregation of MCF-7 human breast cancer cells through its protease activity. In this study, we examined whether aggregation is caused by degradation of adhesion molecules on the culture substrates or through an unidentified mechanism. We compared the...... hiện toàn bộ
Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies
Mediators of Inflammation - Tập 2016 - Trang 1-10 - 2016
Natália Pessoa Rocha, Fabíola M. Ribeiro, Erin Furr‐Stimming, Antônio Lúcio Teixeira
Huntington’s disease (HD) is a neurodegenerative disorder characterized by selective loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline, and psychiatric disorders. Although the cause of HD is well described—HD is a genetic disorder caused by a trinucleotide (CAG) repeat expansion in the gene encoding for huntingtin (HTT<...... hiện toàn bộ
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