Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View

Mediators of Inflammation - Tập 2013 - Trang 1-16 - 2013
Wibke Schulte1,2, Jürgen Bernhagen2, Richard Bucala1
1Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S525, P.O. Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA
2Institute of Biochemistry and Molecular Cell Biology, University Hospital of RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany

Tóm tắt

Sepsis and septic shock are among the leading causes of death in intensive care units worldwide. Numerous studies on their pathophysiology have revealed an imbalance in the inflammatory network leading to tissue damage, organ failure, and ultimately, death. Cytokines are important pleiotropic regulators of the immune response, which have a crucial role in the complex pathophysiology underlying sepsis. They have both pro- and anti-inflammatory functions and are capable of coordinating effective defense mechanisms against invading pathogens. On the other hand, cytokines may dysregulate the immune response and promote tissue-damaging inflammation. In this review, we address the current knowledge of the actions of pro- and anti-inflammatory cytokines in sepsis pathophysiology as well as how these cytokines and other important immunomodulating agents may be therapeutically targeted to improve the clinical outcome of sepsis.

Từ khóa


Tài liệu tham khảo

1992, Chest, 101, 1644, 10.1378/chest.101.6.1644

2001, Critical Care Medicine, 29, 1303, 10.1097/00003246-200107000-00002

10.1056/NEJMoa022139

10.1097/01.CCM.0000261890.41311.E9

10.1186/cc3501

10.1016/S1473-3099(07)70265-7

10.1016/j.ccc.2011.09.003

10.2165/00019053-200422120-00003

10.1007/s00134-006-0392-2

2013, Critical Care Medicine, 41, 580, 10.1097/CCM.0b013e31827e83af

10.1097/01.CCM.0000050454.01978.3B

10.1164/rccm.200208-785OC

10.1164/rccm.200403-324OC

10.1007/BF01705408

2004, Critical Care Medicine, 32, 858, 10.1097/01.CCM.0000117317.18092.E4

10.1038/nature01326

10.1016/j.dci.2011.01.008

10.1056/NEJMoa010307

2012, European Surgical Research, 48, 171, 10.1159/000338194

10.1097/CCM.0b013e3181c98d21

2007, The Journal of Immunology, 179, 5399, 10.4049/jimmunol.179.8.5399

10.1515/CCLM.2011.697

10.1086/514344

10.1016/j.pharmthera.2011.01.014

10.1111/j.1752-8062.2011.00351.x

10.1038/nri1943

2000, Chemical Immunology, 74, 162

2012, Nature Immunology, 13, 902, 10.1038/ni.2404

10.1056/NEJMcibr1004371

10.1016/j.cell.2006.02.015

10.1016/j.chom.2008.05.003

2004, Nature Reviews Immunology, 4, 499, 10.1038/nri1391

10.1097/00008480-200306000-00009

10.1042/BJ20111386

2008, Polskie Archiwum Medycyny Wewnetrznej, 118, 127

2012, Rheumatology, 51, v3, 10.1093/rheumatology/kes113

2010, Critical Reviews in Eukaryotic Gene Expression, 20, 87, 10.1615/CritRevEukarGeneExpr.v20.i2.10

10.1100/2012/756357

10.1179/096805104225006129

1994, Circulatory Shock, 43, 179

2003, Polski Merkuriusz Lekarski, 14, 69

10.1189/jlb.0607373

1992, Proceedings of the National Academy of Sciences of the United States of America, 89, 4754, 10.1073/pnas.89.10.4754

1997, Chest, 112, 321S, 10.1378/chest.112.6_Supplement.321S

1996, The New England Journal of Medicine, 334, 1697, 10.1056/NEJM199606273342603

1989, Journal of Experimental Medicine, 170, 1627, 10.1084/jem.170.5.1627

10.1111/j.1600-065X.2008.00701.x

10.1038/348550a0

1994, Journal of Laboratory and Clinical Medicine, 123, 824

10.1084/jem.183.1.311

10.1038/368339a0

1991, Surgery, 109, 761

1998, Annals of Internal Medicine, 128, 127, 10.7326/0003-4819-128-2-199801150-00009

2007, Bulletin of the NYU hospital for joint diseases, 65, S4

10.1152/japplphysiol.00164.2004

10.1007/s00430-006-0019-9

1990, Blood, 75, 40, 10.1182/blood.V75.1.40.40

2003, American Journal of Physiology, 285, E433, 10.1152/ajpcell.00509.2002

10.1016/S0167-5699(97)01103-1

1994, Blood, 83, 113, 10.1182/blood.V83.1.113.113

1994, Journal of Experimental Medicine, 179, 1253, 10.1084/jem.179.4.1253

10.1074/jbc.M413284200

2012, Trends in Immunology, 33, 571, 10.1016/j.it.2012.07.003

10.1084/jem.187.1.129

10.1084/jem.182.6.1759

2002, Critical Reviews in Immunology, 22, 373

10.1038/nri1001

1997, Annual Review of Immunology, 15, 749, 10.1146/annurev.immunol.15.1.749

1990, Journal of Infectious Diseases, 161, 982, 10.1093/infdis/161.5.982

10.2119/2007-00120.Flohe

2012, American Journal of Respiratory and Critical Care Medicine, 186, 838, 10.1164/rccm.201204-0645OC

1998, Current Opinion in Immunology, 10, 259, 10.1016/S0952-7915(98)80163-5

1965, Science, 149, 310, 10.1126/science.149.3681.310

10.1038/365756a0

10.1038/nm1567

10.1016/j.immuni.2007.03.005

10.1038/377068a0

10.1084/jem.179.6.1895

10.1038/72262

2003, Nature Reviews Immunology, 3, 791, 10.1038/nri1200

10.1016/j.cyto.2009.07.002

10.1016/j.cyto.2012.03.014

10.1073/pnas.012511599

10.1002/eji.200535413

1991, Journal of Experimental Medicine, 174, 1209, 10.1084/jem.174.5.1209

1991, The Journal of Immunology, 147, 3815, 10.4049/jimmunol.147.11.3815

10.1128/IAI.70.8.4441-4446.2002

1995, European Journal of Immunology, 25, 1129, 10.1002/eji.1830250443

10.1056/NEJM200005043421807

1993, Annals of the New York Academy of Sciences, 685, 713, 10.1111/j.1749-6632.1993.tb35934.x

1996, Annals of internal medicine, 125, 520, 10.7326/0003-4819-125-6-199609150-00032

10.1074/jbc.M008170200

1989, Journal of the American Medical Association, 262, 938, 10.1001/jama.1989.03430070086036

1991, European Journal of Immunology, 21, 1635, 10.1002/eji.1830210708

2000, Chest, 117, 1162, 10.1378/chest.117.4.1162

1992, Journal of Experimental Medicine, 176, 1091, 10.1084/jem.176.4.1091

1992, Circulatory Shock, 38, 145

1996, British Journal of Anaesthesia, 77, 110, 10.1093/bja/77.1.110

1996, Nippon Geka Gakkai Zasshi, 97, 771

1996, Journal of Trauma, 40, 702, 10.1097/00005373-199605000-00004

10.1186/cc9392

1997, Advances in Immunology, 66, 101, 10.1016/S0065-2776(08)60597-0

10.1016/S0891-5520(05)70083-0

2010, Nature Immunology, 11

10.1038/nrrheum.2010.196

1991, Proceedings of the National Academy of Sciences of the United States of America, 88, 2830, 10.1073/pnas.88.7.2830

10.1002/path.1491

1987, British Journal of Cancer, 56, 803, 10.1038/bjc.1987.294

1988, Journal of Clinical Oncology, 6, 344, 10.1200/JCO.1988.6.2.344

1990, The New England Journal of Medicine, 322, 1622, 10.1056/NEJM199006073222302

1990, The Lancet, 336, 712, 10.1016/0140-6736(90)92206-W

1991, Blood, 77, 1627, 10.1182/blood.V77.8.1627.1627

1988, The Journal of Clinical Investigation, 81, 1162, 10.1172/JCI113431

1990, Journal of Infectious Diseases, 161, 79, 10.1093/infdis/161.1.79

1988, Surgery Gynecology and Obstetrics, 166, 147

1988, The New England Journal of Medicine, 318, 1481, 10.1056/NEJM198806093182301

1989, The New England Journal of Medicine, 321, 280, 10.1056/NEJM198908033210503

1994, Blood, 84, 1528, 10.1182/blood.V84.5.1528.1528

10.1128/MCB.26.2.699-708.2006

1996, Research Communications in Molecular Pathology and Pharmacology, 91, 329

10.1017/S0265021507003389

1992, The Journal of Clinical Investigation, 90, 533, 10.1172/JCI115891

1995, Journal of Infectious Diseases, 171, 145, 10.1093/infdis/171.1.145

1994, Archives of Surgery, 129, 1330, 10.1001/archsurg.1994.01420360120017

1995, Journal of Infectious Diseases, 172, 296, 10.1093/infdis/172.1.296

1995, Journal of the American Medical Association, 274, 172, 10.1001/jama.1995.03530020090038

1992, The Journal of Clinical Investigation, 89, 1551, 10.1172/JCI115748

1991, Circulatory Shock, 33, 84

1992, Annals of Surgery, 215, 356, 10.1097/00000658-199204000-00009

1990, Clinical Science, 79, 161, 10.1042/cs0790161

1993, Critical Care Medicine, 21, 839, 10.1097/00003246-199306000-00010

1989, Blood, 74, 1704, 10.1182/blood.V74.5.1704.1704

10.1097/00003246-199603000-00006

1989, Journal of Experimental Medicine, 169, 333, 10.1084/jem.169.1.333

1991, Cytokine, 3, 1, 10.1016/1043-4666(91)90002-U

10.1016/S0950-3579(05)80113-X

1999, The Journal of Immunology, 163, 5094, 10.4049/jimmunol.163.9.5094

1999, European Cytokine Network, 10, 191

10.1016/S0140-6736(03)15326-3

1996, Journal of Interferon and Cytokine Research, 16, 995, 10.1089/jir.1996.16.995

1998, The Journal of Clinical Investigation, 101, 311, 10.1172/JCI1368

10.1128/IAI.73.5.2751-2757.2005

10.1007/s12026-011-8209-y

1999, The Journal of Immunology, 162, 5437, 10.4049/jimmunol.162.9.5437

1997, Shock, 8, 349, 10.1097/00024382-199711000-00006

1996, Blood, 87, 5144, 10.1182/blood.V87.12.5144.bloodjournal87125144

2006, The Journal of Immunology, 177, 3218, 10.4049/jimmunol.177.5.3218

10.1097/00000658-200204000-00015

2005, Intensive Care Medicine, 31, 401, 10.1007/s00134-005-2575-7

10.1186/cc10464

1994, Journal of Experimental Medicine, 179, 1367, 10.1084/jem.179.4.1367

1993, Science, 259, 1742, 10.1126/science.8456301

10.1084/jem.178.6.2243

1994, Science, 264, 1918, 10.1126/science.8009221

1990, The Journal of Immunology, 145, 2920, 10.4049/jimmunol.145.9.2920

1994, Journal of Experimental Medicine, 179, 1437, 10.1084/jem.179.5.1437

1991, The Journal of Clinical Investigation, 88, 1747, 10.1172/JCI115493

10.1007/s001340050795

1932, Bulletin of the Johns Hopkins Hospital, 50, 115

10.1073/pnas.95.19.11383

10.4049/jimmunol.0803710

10.1038/414920a

10.1016/j.immuni.2006.08.020

10.1084/jem.20030286

1998, The Journal of Clinical Investigation, 101, 2869, 10.1172/JCI1524

1997, The Journal of Immunology, 158, 5514, 10.4049/jimmunol.158.11.5514

2000, Circulation Research, 87, 1202, 10.1161/01.RES.87.12.1202

2001, Nature Immunology, 2, 1061, 10.1038/ni720

10.1074/jbc.C500243200

10.1084/jem.189.2.341

10.1165/rcmb.2005-0272OC

10.1002/hep.510290610

2003, American Journal of Physiology, 285, H2500

10.1038/nature06504

10.1073/pnas.1102941108

10.1210/jc.86.6.2811

10.1016/j.jss.2010.05.004

10.1096/fj.09-129445

10.1096/fj.11-195065

10.1016/j.cyto.2010.12.010

10.1086/600894

1993, Journal of Experimental Medicine, 177, 1205, 10.1084/jem.177.4.1205

1992, Journal of Clinical Immunology, 12, 239, 10.1007/BF00918147

10.1016/S0039-6060(99)70180-7

1995, The Journal of Immunology, 155, 5397, 10.4049/jimmunol.155.11.5397

2009, Critical Care, 13

1997, Immunological Investigations, 26, 459, 10.3109/08820139709022702

10.1007/s10875-008-9251-y

1995, Journal of Experimental Medicine, 181, 1887, 10.1084/jem.181.5.1887

1996, Proceedings of the National Academy of Sciences of the United States of America, 93, 2054, 10.1073/pnas.93.5.2054

1996, European Cytokine Network, 7, 137

10.1517/13543784.11.8.1061

10.1006/clin.1998.4523

10.1097/01.CCM.0000254341.87098.A4

1996, The Journal of Immunology, 157, 4926, 10.4049/jimmunol.157.11.4926

1995, Blood, 86, 3705, 10.1182/blood.V86.10.3705.bloodjournal86103705

2002, The Journal of Immunology, 169, 3574, 10.4049/jimmunol.169.7.3574

1998, European Journal of Immunology, 28, 610, 10.1002/(SICI)1521-4141(199802)28:02<610::AID-IMMU610>3.0.CO;2-5

1999, European Journal of Immunology, 29, 2400, 10.1002/(SICI)1521-4141(199908)29:08<2400::AID-IMMU2400>3.0.CO;2-E

2008, Journal of Critical Care, 23, 519, 10.1016/j.jcrc.2007.11.008

10.1097/TA.0b013e3182115034

1993, Critical Care Medicine, 21, 318, 10.1097/00003246-199303000-00006

10.1097/00003246-199707000-00010

10.1097/00003246-199707000-00001

1996, Critical Care Medicine, 24, 1431, 10.1097/00003246-199609000-00002

10.1196/annals.1418.011

10.1016/j.molmed.2004.12.007

10.1074/jbc.M203220200

10.4049/jimmunol.1001767

10.1172/JCI32218

10.1074/jbc.M111.329664

10.1016/j.bmcl.2010.07.129

10.1096/fj.10-168559

10.1164/rccm.2009005

10.1378/chest.127.6.2139

10.1016/0002-9610(92)90099-D

10.1111/j.1365-2141.2005.05753.x

2003, Chest, 124, 26S, 10.1378/chest.124.3_suppl.26S

10.1111/j.1476-5381.2009.00251.x

10.1371/journal.pone.0015904

10.1093/bja/aen079

10.1034/j.1600-065x.2001.1840123.x

2000, European Cytokine Network, 11, 407

10.1097/01.CCM.0000251133.26979.F4

10.1007/s10495-009-0320-3

1987, The Journal of Clinical Investigation, 79, 918, 10.1172/JCI112902

2001, Critical Care Medicine, 29, 2051, 10.1097/00003246-200111000-00003

10.1056/NEJM200103083441001

2008, Critical Care Medicine, 36, 296, 10.1097/01.CCM.0000298158.12101.41

2012, The New England Journal of Medicine, 366, 2055, 10.1056/NEJMoa1202290

Thông tin
Thông tin xuất bản

Mediators of Inflammation

Tập 2013

1-16

Thông tin tác giả