Role of Reactive Oxygen Species in the Progression of Type 2 Diabetes and Atherosclerosis

Mediators of Inflammation - Tập 2010 - Trang 1-11 - 2010
Hideaki Kaneto1, Naoto Katakami1, Munehide Matsuhisa1, Taka‐aki Matsuoka1
1Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

Tóm tắt

Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic -cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate -cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.

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Mediators of Inflammation

Tập 2010

1-11

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