Magnetic Resonance in Medicine

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Changes in water diffusion due to Wallerian degeneration in peripheral nerve
Magnetic Resonance in Medicine - Tập 36 Số 4 - Trang 627-631 - 1996
Christian Beaulieu, Mark D. Does, R. E. Snyder, Peter S. Allen
AbstractThe authors report NMR measurements of the changes in water diffusion brought about by in vivo Wallerian degeneration due to either crush‐ or tie‐injuries in the sciatic nerve of the frog. Using a pulsed‐gradient spin‐echo sequence with a diffusion measurement time of 28 ms, the degree of diffusion coefficient anisotropy {D(longitudinal)/D(transverse)} 4 weeks after injury in both crush‐ a... hiện toàn bộ
Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
Magnetic Resonance in Medicine - Tập 57 Số 4 - Trang 688-695 - 2007
Matthew D. Budde, Joong Hee Kim, Hsiao‐Fang Liang, Robert E. Schmidt, John H. Russell, Anne H. Cross, Sheng‐Kwei Song
AbstractDiffusion tensor imaging (DTI) has been widely applied to investigate injuries in the central nervous system (CNS) white matter (WM). However, the underlying pathological correlates of diffusion changes have not been adequately determined. In this study the coregistration of histological sections to MR images and a pixel‐based receiver operating characteristic (ROC) analysis were used to c... hiện toàn bộ
Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd‐DTPA: Kinetic modeling in canine ischemic disease
Magnetic Resonance in Medicine - Tập 23 Số 2 - Trang 239-253 - 1992
Leo D. Diesbourg, Frank S. Prato, Gerald Wisenberg, Dick Drost, Tara P. Marshall, S E Carroll, Blair J. O’Neill
AbstractIn order to clarify the relationship between coronary artery disease (including myocardial infarction) and image contrast in gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA‐enhanced MRI it was decided to model the myocardial tissue distribution and clearance of Gd‐DTPA using the modified Kety equation. Using a canine model, myocardial tissue Gd‐DTPA concentrations ([Gd‐DTPA]m) were ... hiện toàn bộ
Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine
Magnetic Resonance in Medicine - Tập 30 Số 3 - Trang 332-336 - 1993
Chun Tong, Frank S. Prato, Gerald Wisenberg, Ting Y. Lee, Edwin Carroll, Daivid Sandler, J. M. Wills
AbstractWe have previously shown that the concentration of Gd‐DTPA as, a function of time ([Gd‐DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd‐DTPA can be moldered using the Modified Kety Equation. Fitting this model to measurements of [Gd‐DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (λ) and the product of flow (F) ... hiện toàn bộ
Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia
Magnetic Resonance in Medicine - Tập 29 Số 4 - Trang 485-497 - 1993
Norbert Wilke, C. Simm, Jianyi Zhang, Jutta Ellermann, Ya Xiong, Hellmut Merkle, G. Path, Henry H. Ludemann, Robert J. Bache, Kâmil Uǧurbil
AbstractThe sensitivity of contrast‐enhanced MR first pass perfusion imaging in detection and quantification of hypoperfused myocardium was evaluated using an instrumented, closed‐chest dog model where graded regional hypoperfusion was induced by applying predetermined levels of stenosis to the left anterior descending artery (LAD). All measurements were performed at rest and under stress induced ... hiện toàn bộ
Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardium
Magnetic Resonance in Medicine - Tập 30 Số 3 - Trang 337-346 - 1993
Chun Tong, Frank S. Prato, Gerald Wisenberg, Ting Y. Lee, Edwin Carroll, David Sandler, J. M. Wills, Dick Drost
AbstractWe have previously shown that the myocardial Gd‐DTPA concentration ([Gd‐DTPA]t(t)) after a bolus injection of Gd‐DTPA can be predicted by the Modified Kety Equation (MKE). If [Gd‐DTPA]t(t) can be determined by MRI and the data fit to the MICE, then the distribution volume (λ) of Gd‐DTPA and the myocardial flow (F) times the extraction efficiency (E), i.e., the FE product, can be determined... hiện toàn bộ
MRI detection of myocardial perfusion changes by gadolinium‐DTPA infusion during dipyridamole hyperemia
Magnetic Resonance in Medicine - Tập 10 Số 2 - Trang 246-255 - 1989
D. Douglas Miller, Godtfred Holmvang, John B. Gill, Donna Dragotakes, Howard L. Kantor, Robert D. Okada, Thomas J. Brady
AbstractTo detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for ... hiện toàn bộ
Dependence of MR signal intensity on Gd tissue concentration over a broad dose range
Magnetic Resonance in Medicine - Tập 22 Số 2 - Trang 191-194 - 1991
Michael F. Tweedle, P. Wedeking, Joshua Telser, Christopher H. Sotak, C. Allen Chang, Krishan Kumar, Xiao Wan, Stephen Eaton
Inversion recovery EPI of bolus transit in rat myocardium using intravascular and extravascular gadolinium‐based MR contrast media: Dose effects on peak signal enhancement
Magnetic Resonance in Medicine - Tập 32 Số 3 - Trang 319-329 - 1994
Michael F. Wendland, Maythem Saeed, K K Yu, Timothy P. L. Roberts, Kirsi Lauerma, Nikita Derugin, John Varadarajan, Alan D. Watson, Charles B. Higgins
AbstractInversion recovery gradient recalled echo planar imaging (TI/TR/TE = 700/2000/10 ms) was used to dynamically monitor the first pass of an intravascular (GdDOTA‐polylysine) and an extravascular (GdDTPA‐BMA) contrast agent through normal rat myocardium. It was found that myocardial enhancement increased with dose of the intravascutar agent to a limiting value of ∼50% of fully relaxed intensi... hiện toàn bộ
Practical Implementation and Optimization of One‐shot T1 imaging
Magnetic Resonance in Medicine - Tập 22 Số 2 - Trang 414-424 - 1991
I Kay, R. Mark Henkelman
AbstractLongitudinal relaxation times (T1) can be measured rapidly in an imaging context using a “one‐shot” method based on the pulse sequence originally proposed by D. C. Look and D. R. Locker (Rev. Sci. Instrum. 41, 250 1970). This sequence is significantly faster than either repeated inversion recovery or repeated saturation recovery methods. The method uses a 180° inversion pulse followed by m... hiện toàn bộ
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