Measurement of the extraction efficiency and distribution volume for Gd‐DTPA in normal and diseased canine myocardium

Magnetic Resonance in Medicine - Tập 30 Số 3 - Trang 337-346 - 1993
Chun Tong1, Frank S. Prato2,1, Gerald Wisenberg3,2, Ting Y. Lee4, Edwin Carroll1,5, David Sandler1,5, J. M. Wills2, Dick Drost2
1Department of Physics, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
2Department of Nuclear Medicine and Magnetic Resonance, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
3Department of Medicine, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
4Department of Radiology, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada
5Department of Surgery, Lawson Research Institute, St. Joseph's Health Centre, University of Western Ontario, London, Ontario, Canada

Tóm tắt

AbstractWe have previously shown that the myocardial Gd‐DTPA concentration ([Gd‐DTPA]t(t)) after a bolus injection of Gd‐DTPA can be predicted by the Modified Kety Equation (MKE). If [Gd‐DTPA]t(t) can be determined by MRI and the data fit to the MICE, then the distribution volume (λ) of Gd‐DTPA and the myocardial flow (F) times the extraction efficiency (E), i.e., the FE product, can be determined. Therefore F can only be quantified if E is known. We measured the global E in vivo in normal canine myocardium, and measured E and λ, in vitro, locally in normal, acute ischemic (n = 5; coronary artery occlusion < 4 h), infarcted (n = 4; coronary artery occlusion, 6 days) and reperfused (n = 4; coronary artery occlusion 2 h, and reperfusion 2 h and 6 days) myocardium. Results indicate that E differs with F and with individuals and consequently, F cannot be quantified using the MKE unless the local E is also determined in vivo.

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