Inversion recovery EPI of bolus transit in rat myocardium using intravascular and extravascular gadolinium‐based MR contrast media: Dose effects on peak signal enhancement

Magnetic Resonance in Medicine - Tập 32 Số 3 - Trang 319-329 - 1994
Michael F. Wendland1, Maythem Saeed1, K K Yu1, Timothy P. L. Roberts1, Kirsi Lauerma1, Nikita Derugin1, John Varadarajan1, Alan D. Watson1, Charles B. Higgins
1Department of Radiology, University of California, San Francisco, California, and Nycomed Salutar, Sunnyvale, California

Tóm tắt

AbstractInversion recovery gradient recalled echo planar imaging (TI/TR/TE = 700/2000/10 ms) was used to dynamically monitor the first pass of an intravascular (GdDOTA‐polylysine) and an extravascular (GdDTPA‐BMA) contrast agent through normal rat myocardium. It was found that myocardial enhancement increased with dose of the intravascutar agent to a limiting value of ∼50% of fully relaxed intensity, consistent with enhancement of 40% of myocardial water content during the first pass. Larger doses produced no further increase in peak response. On the other hand, the extravascular agent caused incrementally increased enhancement throughout the dose range examined to a final value of 68 ± 2% of fully relaxed intensity. The profile of dose dependence for both agents was inconsistent with monoexponential T1 relaxation. It was concluded that (a) compartmentalization of myocardial water combined with restricted myocardial water diffusion limits the peak response during bolus transit; (b) extraction of the extravascular agent during transit elevates the peak response over that obtained from agent confined to the vascular volume; and (c) models that assume simple monoexponential r, relaxation to derive timedensity curves do not adequately describe the relationship between changes in signal intensity, R1 and contrast concentration.

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Magnetic Resonance in Medicine

Tập 32 Số 3

319-329

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