Quantification of intramyocellular lipids in obese subjects using spectroscopic imaging with high spatial resolution

Magnetic Resonance in Medicine - Tập 57 Số 1 - Trang 22-28 - 2007
Ján Weis1,2, Lars Johansson3, Frédéric Courivaud4, F. Anders Karlsson5, Håkan Åhlström2
1Department of Medical Informatics and Bioengineering, Uppsala University Hospital, Uppsala, Sweden
2MR Unit, Department of Radiology, Uppsala University Hospital, Uppsala, Sweden
3Astra Zeneca R&D, Uppsala University Hospital, Uppsala, Sweden
4Philips Medical Systems, Oslo, Norway
5Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden

Tóm tắt

AbstractQuantification of intramyocellular lipids (IMCL) in obese subjects by single‐voxel spectroscopy (SVS) or conventional spectroscopic imaging (SI) often fails due to overlap of IMCL spectral lines by extramyocellular lipids (EMCL), and signal contamination from subcutaneous fat and bone marrow. This study demonstrates that these problems can be solved by high‐resolution SI with 128 phase‐encoding steps and a read gradient during acquisition. The small voxels obtained in this way facilitated differentiation between EMCL and IMCL. This method offers the possibility of studying different muscle groups and the variation of lipids within one muscle. Magn Reson Med 57:22–28, 2007. © 2006 Wiley‐Liss, Inc.

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Magnetic Resonance in Medicine

Tập 57 Số 1

22-28

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