Toward accurate diagnosis of white matter pathology using diffusion tensor imaging

Magnetic Resonance in Medicine - Tập 57 Số 4 - Trang 688-695 - 2007
Matthew D. Budde1, Joong Hee Kim2, Hsiao‐Fang Liang1, Robert E. Schmidt3, John H. Russell4, Anne H. Cross5, Sheng‐Kwei Song1
1Department of Radiology, Washington University, St. Louis, Missouri, USA
2Department of Chemistry, Washington University, St Louis, Missouri, USA.
3Department of Pathology and Immunology, Washington University, St Louis, Missouri, USA
4Department of Molecular Biology and Pharmacology, Washington University, St. Louis, Missouri, USA
5Department of Neurology, Washington University, St. Louis, Missouri, USA

Tóm tắt

AbstractDiffusion tensor imaging (DTI) has been widely applied to investigate injuries in the central nervous system (CNS) white matter (WM). However, the underlying pathological correlates of diffusion changes have not been adequately determined. In this study the coregistration of histological sections to MR images and a pixel‐based receiver operating characteristic (ROC) analysis were used to compare the axial (λ∥) and radial (λ⟂) diffusivities derived from DTI and histological markers of axon (phosphorylated neurofilament, SMI‐31) and myelin (Luxol fast blue (LFB)) integrity, respectively, in two different patterns of injury to mouse spinal cord (SC) WM. In contusion SC injury (SCI), a decrease in λ∥ matched the pattern of axonal damage with high accuracy, but λ⟂ did not match the pattern of demyelination detected by LFB. In a mouse model of multiple sclerosis (MS), λ⟂ and λ∥ did not match the patterns of demyelination or axonal damage, respectively. However, a region of interest (ROI) analysis suggested that λ⟂‐detected demyelination paralleled that observed with LFB, and λ∥ decreased in both regions of axonal damage and normal‐appearing WM (NAWM) as visualized by SMI‐31. The results suggest that directional diffusivities may reveal abnormalities that are not obvious with SMI‐31 and LFB staining, depending on the type of injury. Magn Reson Med 57:688–695, 2007. © 2007 Wiley‐Liss, Inc.

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Thông tin xuất bản

Magnetic Resonance in Medicine

Tập 57 Số 4

688-695

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