Journal of Veterinary Pharmacology and Therapeutics
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A pharmacokinetic study of digoxin in the horseDigoxin was administered orally and intravenously to seven healthy adult mares and geldings in two separate trials. At a dose of 44 μg digoxin/kg body weight, the oral study was characterized by an absorption phase with a mean (± 1 standard deviation) peak serum digoxin concentration of 2.21 ng/ml (± 0.45) at a mean of 2.29 h (± 1.52) after administration. A second rise in serum digoxin co... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 6 Số 3 - Trang 163-172 - 1983
Plasma clearancePlasma (total, systemic…) clearance is determined by all the individual metabolizing/eliminating organ clearances and involves mainly liver and kidney clearances. Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level. The interpret... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 27 Số 6 - Trang 415-425 - 2004
Dược động học, tác dụng dược lý và ảnh hưởng hành vi của acepromazine trên ngựa Dịch bởi AI Sau khi tiêm tĩnh mạch (i.v.), acepromazine được phân bố rộng rãi trong ngựa (Vd = 6,6 lít/kg) và gắn chặt (>99%) vào protein huyết tương. Mức độ của thuốc trong huyết tương giảm xuống với pha α có thời gian bán thải là 4,2 phút, trong khi pha β hoặc thời gian bán thải là 184,8 phút. Ở mức liều 0,3 mg/kg, acepromazine có thể được phát hiện tro... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 5 Số 1 - Trang 21-31 - 1982
#acepromazine #ngựa #dược động học #phản ứng dược lý #đào thải #bộ phận sinh dục #hồng cầu #nghiên cứu động vật
The biology, pathophysiology and control of eicosanoids in inflammationHiggins, A.J. The biology, pathophysiology and control of eicosanoids in inflammation. J. vet. Pluirmacol. Therap. 8, 1–18. The involvement in inflammatory conditions of those cyclo‐oxygenase and lipoxygenase derivatives of arachidonic acid (5, 8, 11, 14‐eicosatetraenoic acid), which are known as the eicosanoids, is reviewed iti the light of recen... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 8 Số 1 - Trang 1-18 - 1985
Intracellular killing of mastitis pathogens by penethamate hydriodide following internalization into mammary epithelial cellsPenethamate hydriodide was highly effective in killing Streptococcus uberis , Streptococcus dysgalactiae subsp. dysgalactiae and Staphylococcus aureus that internalized mammary epithelial cells. At higher concentrations (32 μ g/mL to 32 mg/mL), killing rates ... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 30 Số 2 - Trang 151-156 - 2007
Plasma terminal half‐lifeTerminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limi... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 27 Số 6 - Trang 427-439 - 2004
Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokineticsIntravenous (IV) levetiracetam (LEV) is available for humans for bridge therapy when the oral route is unavailable. We investigated the safety and pharmacokinetics of LEV administered intramuscularly (IM), IV, and orally to dogs. Six Hound dogs received 19.5–22.6 mg/kg of LEV IM, IV and orally with a wash‐out period in between. All dogs received 500 mg LEV orally and 5 mL o... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 31 Số 3 - Trang 253-258 - 2008
Pharmacokinetics of zonisamide and drug interaction with phenobarbital in dogsThe purposes of the present study were to elucidate the pharmacokinetics of zonisamide, determine the presence of a drug interaction with phenobarbital, and evaluate how long any interaction lasted after discontinuation of phenobarbital in dogs. Five dogs received zonisamide (5 mg/kg, p.o. and i.v.) before and during repeated oral administration of phenobarbital (5 mg/kg, bid, for 30–35 da... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 31 Số 3 - Trang 259-264 - 2008
The influence of the rumen on the absorption of drugs: studies using meclofenamic acid administered by various routes to sheep and cattleAs part of a general study of the pharmacokinetics of drugs in the ruminant animal, the absorption and distribution kinetics of meclofenamic acid between the gastro‐intestinal tract and plasma of sheep and cattle were investigated. Meclofenamic acid is a non‐steroidal anti‐inflammatory drug which has been shown to possess anti‐anaphylactic activity in cattle (Aitken & Sanford, 1969; 19... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 2 Số 2 - Trang 109-115 - 1979
Influence of closure of the reticular groove on the bioavailability and disposition kinetics of meclofenamate in sheepSodium meclofenamate is a non‐steroidal anti‐inflammatory drug with anaphylactic protective activity in cattle. The objectives of this study were to describe the pharmacokinetic behaviour of sodium meclofenamate after intravenous and oral administration to sheep and to determine the influence of closure of the reticular groove on the bioavailability of the drug. Sodium meclofenamate was ad... ... hiện toàn bộ
Journal of Veterinary Pharmacology and Therapeutics - Tập 19 Số 1 - Trang 15-21 - 1996
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