Journal of Veterinary Pharmacology and Therapeutics

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Toxicologic effects of ribavirin in cats
Journal of Veterinary Pharmacology and Therapeutics - Tập 16 Số 3 - Trang 301-316 - 1993
Richard C. Weiss, Nancy R. Cox, Mary K. Boudreaux
Ribavirin, a broad‐spectrum antiviral agent active in vitro against a number of RNA and DNA viruses, has been associated with moderate toxicity in laboratory animals and humans. Clinically, ribavirin has been used effectively in persons primarily to treat life‐threatening viral diseases such as acute haemorrhagic fever or viral pneumonia of infants. In order to e...... hiện toàn bộ
Dược động học, tác dụng dược lý và ảnh hưởng hành vi của acepromazine trên ngựa Dịch bởi AI
Journal of Veterinary Pharmacology and Therapeutics - Tập 5 Số 1 - Trang 21-31 - 1982
Steve Ballard, Theodore Shults, A. A. Kownacki, J W Blake, Thomas Tobin
Sau khi tiêm tĩnh mạch (i.v.), acepromazine được phân bố rộng rãi trong ngựa (Vd= 6,6 lít/kg) và gắn chặt (>99%) vào protein huyết tương. Mức độ của thuốc trong huyết tương giảm xuống với pha α có thời gian bán thải là 4,2 phút, trong khi pha β hoặc thời gian bán thải là 184,8 phút. Ở mức liều 0,3 mg/kg, acepromazine có thể được phát hiện tro...... hiện toàn bộ
#acepromazine #ngựa #dược động học #phản ứng dược lý #đào thải #bộ phận sinh dục #hồng cầu #nghiên cứu động vật
The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds
Journal of Veterinary Pharmacology and Therapeutics - Tập 41 Số 5 - Trang 670-683 - 2018
Trevor Elwell‐Cuddy, Miao Li, Butch KuKanich, Zhoumeng Lin
AbstractMethadone is an opioid analgesic in veterinary and human medicine. To help develop appropriate pain management practices and to develop a quantitative model for predicting methadone dosimetry, a flow‐limited multiroute physiologically based pharmacokinetic (PBPK) model for methadone in dogs constructed with Berkeley Madonna™ was developed. The model account...... hiện toàn bộ
Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats
Journal of Veterinary Pharmacology and Therapeutics - Tập 35 Số 2 - Trang 121-131 - 2012
Teresa L. Leavens, Lisa A. Tell, Kristin A. Clothier, Ronald W. Griffith, Ronald E. Baynes, Jim E. Riviere
Leavens, T. L., Tell, L. A., Clothier, K. A., Griffith, R. W., Baynes, R. E., Riviere, J. E. Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats. J. vet. Pharmacol. Therap. 35, 121–131.Physiologically based pharmacokinetic (PBPK) models, which incorporate species‐ and ...... hiện toàn bộ
Molecular mechanisms for anthelmintic resistance in strongyle nematode parasites of veterinary importance
Journal of Veterinary Pharmacology and Therapeutics - Tập 40 Số 2 - Trang 105-115 - 2017
John Whittaker, Steve A. Carlson, Douglas E. Jones, Matthew T. Brewer
Veterinarians rely on a relatively limited spectrum of anthelmintic agents to control nematode parasites in domestic animals. Unfortunately, anthelmintic resistance has been an emerging problem in veterinary medicine. In particular, resistance has emerged among the strongyles, a group of gastrointestinal nematodes that infect a variety of hosts that range from large herbivores to small com...... hiện toàn bộ
The influence of chronic pain on the analgesic effects of the α2‐adrenoceptor agonist, xylazine, in sheep
Journal of Veterinary Pharmacology and Therapeutics - Tập 14 Số 2 - Trang 141-144 - 1991
S Ley, A.E. Waterman, A. Livingston
A comparison of the analgesic potency of the α2‐adrenoceptor agonist, xylazine, in control healthy sheep and sheep suffering chronic pain from footrot, indicated that the analgesic effectiveness of xylazine was significantly reduced in the animals experiencing chronic pain. This was measured by recording the threshold to a mechanically applied pressure stimulus. Furthe...... hiện toàn bộ
Antinociceptive activity and mechanism of action of detomidine
Journal of Veterinary Pharmacology and Therapeutics - Tập 9 Số 3 - Trang 286-292 - 1986
Raimo Virtanen
The antinociceptive activity and mechanism of action of detomidine, a novel sedative‐analgesic, were studied in mice and rats. Xylazine and morphine were included in the studies for comparison. In both acetic acid‐induced writhing test in mice, and in tail flick test in rats, detomidine had potent, dose‐dependent antinociceptive effects with ED50 values of 0.06 and 0.2...... hiện toàn bộ
The influence of the rumen on the absorption of drugs: studies using meclofenamic acid administered by various routes to sheep and cattle
Journal of Veterinary Pharmacology and Therapeutics - Tập 2 Số 2 - Trang 109-115 - 1979
S. E. Marriner, J. Bogan
As part of a general study of the pharmacokinetics of drugs in the ruminant animal, the absorption and distribution kinetics of meclofenamic acid between the gastro‐intestinal tract and plasma of sheep and cattle were investigated. Meclofenamic acid is a non‐steroidal anti‐inflammatory drug which has been shown to possess anti‐anaphylactic activity in cattle (Aitken & Sanford, 1969; 19...... hiện toàn bộ
Influence of closure of the reticular groove on the bioavailability and disposition kinetics of meclofenamate in sheep
Journal of Veterinary Pharmacology and Therapeutics - Tập 19 Số 1 - Trang 15-21 - 1996
Teresa Encinas, E. Vinagre, Juan Carlos Boggio, M. D. San Andrés, Casilda Rodríguez, M. I. San Andrés
Sodium meclofenamate is a non‐steroidal anti‐inflammatory drug with anaphylactic protective activity in cattle. The objectives of this study were to describe the pharmacokinetic behaviour of sodium meclofenamate after intravenous and oral administration to sheep and to determine the influence of closure of the reticular groove on the bioavailability of the drug. Sodium meclofenamate was ad...... hiện toàn bộ
Plasma terminal half‐life
Journal of Veterinary Pharmacology and Therapeutics - Tập 27 Số 6 - Trang 427-439 - 2004
Pierre‐Louis Toutain, Alain Bousquet‐mélou
Terminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limi...... hiện toàn bộ
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