Plasma terminal half‐life

Journal of Veterinary Pharmacology and Therapeutics - Tập 27 Số 6 - Trang 427-439 - 2004
Pierre‐Louis Toutain1, Alain Bousquet‐mélou1
1UMR 181 Physiopathologie et Toxicologie Expérimentales INRA/ENVT, Ecole Nationale Vétérinaire de Toulouse, Toulouse cedex 03, France

Tóm tắt

Terminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limiting factor, the terminal half‐life reflects rate and extent of absorption and not the elimination process (flip‐flop pharmacokinetics). The terminal half‐life is especially relevant to multiple dosing regimens, because it controls the degree of drug accumulation, concentration fluctuations and the time taken to reach equilibrium.

Từ khóa


Tài liệu tham khảo

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Thông tin xuất bản

Journal of Veterinary Pharmacology and Therapeutics

Tập 27 Số 6

427-439

Thông tin tác giả