Journal of Veterinary Pharmacology and Therapeutics

SCIE-ISI SCOPUS (1978-2023)

  0140-7783

  1365-2885

  Anh Quốc

Cơ quản chủ quản:  Wiley-Blackwell Publishing Ltd , WILEY

Lĩnh vực:
PharmacologyVeterinary (miscellaneous)

Các bài báo tiêu biểu

Xylazine – a review of its pharmacology and use in veterinary medicine
Tập 11 Số 4 - Trang 295-313 - 1988
Stephen A. Greene, Thurmon Jc
Plasma terminal half‐life
Tập 27 Số 6 - Trang 427-439 - 2004
Pierre‐Louis Toutain, Alain Bousquet‐mélou
Terminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limi...... hiện toàn bộ
Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs
Tập 23 Số 1 - Trang 15-20 - 2000
Kuusela, Marja Raekallio, Anttila, Falck, Mölsä, Outi Vainio
The clinical effects and pharmacokinetics of medetomidine (MED) and its enanti‐omers, dexmedetomidine (DEX) and levomedetomidine (LEVO) were compared in a group of six beagle dogs. The dogs received intravenously (i.v.) a bolus of MED (40 μg/kg), DEX (20 and 10 μg/kg), LEVO (20 and 10 μg/kg), and saline placebo in a blinded, randomized block study in six separate sessions. Sedation and ana...... hiện toàn bộ
Plasma clearance
Tập 27 Số 6 - Trang 415-425 - 2004
Pierre‐Louis Toutain, Alain Bousquet‐mélou
Plasma (total, systemic…) clearance is determined by all the individual metabolizing/eliminating organ clearances and involves mainly liver and kidney clearances. Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level. The interpret...... hiện toàn bộ
The pharmacokinetics of xylazine hydrochloride: an interspecific study
Tập 4 Số 2 - Trang 87-92 - 1981
Rafael Garcia Villar, Pierre‐Louis Toutain, M. Alvinerie, Y. Ruckebusch
The pharmacokinetic disposition of xylazine hydrochloride is described after both intravenous and intramuscular injection of a single dose, in four domestic species: horse, cattle, sheep and dog, by an original high performance liquid chromatographic technique. Remarkably small interspecific differences are reported. After intravenous administration, systemic half‐life (t... hiện toàn bộ
Pharmacokinetics of florfenicol in veal calves
Tập 9 Số 4 - Trang 412-425 - 1986
K.J. Varma, Patrick Adams, Thomas F. Powers, Jean D. Powers, J. F. Lamendola
Varma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F. Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9, 412–425.The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22‐mg/kg dose intravenously, orally after a 12‐h fast a...... hiện toàn bộ
Pharmacokinetics and anesthetic activity of eugenol in male Sprague–Dawley rats
Tập 29 Số 4 - Trang 265-270 - 2006
Sarah Annie Guénette, Francis Beaudry, Jean‐François Marier, Pascal Vachon
Eugenol, the principle chemical constituent of clove oil, has recently been evaluated for its anesthetic and analgesic properties in fish and amphibians. The objective of this study was to determine the pharmacokinetic (PK) and anesthetic activity of eugenol in rats. Male Sprague–Dawley rats received single i.v. doses of eugenol (0, 5, 10, 20, 40 and 60 mg/kg) and anesthetic level was eval...... hiện toàn bộ
Pharmacokinetics of enrofloxacin in fingerling rainbow trout (Oncorhynchus mykiss)
Tập 15 Số 1 - Trang 62-71 - 1992
Paul R. Bowser, Gregory A. Wooster, Judy St. Leger, John G. Babish
The pharmacokinetics of intravenously and orally administered enrofloxacin was determined in fingerling rainbow trout (Oncorhymhur mykiss). Doses of 5 or 10 mg enrofloxacin /kg body weight were administered intravenously to 26 fish for each dose and blood was sampled over a 60‐h period at 15°C. Two groups of fish were treated orally with 5, 10, or 50 mg/kg (80 fi...... hiện toàn bộ
Mathematical modeling and simulation in animal health – Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment
Tập 39 Số 5 - Trang 421-438 - 2016
Zhoumeng Lin, Ronette Gehring, Jonathan P. Mochel, Thierry Lavé, Jim E. Riviere
This review provides a tutorial for individuals interested in quantitative veterinary pharmacology and toxicology and offers a basis for establishing guidelines for physiologically based pharmacokinetic (PBPK) model development and application in veterinary medicine. This is important as the application of ... hiện toàn bộ
Dược động học, tác dụng dược lý và ảnh hưởng hành vi của acepromazine trên ngựa Dịch bởi AI
Tập 5 Số 1 - Trang 21-31 - 1982
Steve Ballard, Theodore Shults, A. A. Kownacki, J W Blake, Thomas Tobin
Sau khi tiêm tĩnh mạch (i.v.), acepromazine được phân bố rộng rãi trong ngựa (Vd= 6,6 lít/kg) và gắn chặt (>99%) vào protein huyết tương. Mức độ của thuốc trong huyết tương giảm xuống với pha α có thời gian bán thải là 4,2 phút, trong khi pha β hoặc thời gian bán thải là 184,8 phút. Ở mức liều 0,3 mg/kg, acepromazine có thể được phát hiện tro...... hiện toàn bộ
#acepromazine #ngựa #dược động học #phản ứng dược lý #đào thải #bộ phận sinh dục #hồng cầu #nghiên cứu động vật