Plasma terminal half‐life Tập 27 Số 6 - Trang 427-439 - 2004
Pierre‐Louis Toutain, Alain Bousquet‐mélou
Terminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limi...... hiện toàn bộ Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs Tập 23 Số 1 - Trang 15-20 - 2000
Kuusela, Marja Raekallio, Anttila, Falck, Mölsä, Outi Vainio
The clinical effects and pharmacokinetics of medetomidine (MED) and its enanti‐omers, dexmedetomidine (DEX) and levomedetomidine (LEVO) were compared in a group of six beagle dogs. The dogs received intravenously (i.v.) a bolus of MED (40 μg/kg), DEX (20 and 10 μg/kg), LEVO (20 and 10 μg/kg), and saline placebo in a blinded, randomized block study in six separate sessions. Sedation and ana...... hiện toàn bộ Plasma clearance Tập 27 Số 6 - Trang 415-425 - 2004
Pierre‐Louis Toutain, Alain Bousquet‐mélou
Plasma (total, systemic…) clearance is determined by all the individual metabolizing/eliminating organ clearances and involves mainly liver and kidney clearances. Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level. The interpret...... hiện toàn bộ The pharmacokinetics of xylazine hydrochloride: an interspecific study Tập 4 Số 2 - Trang 87-92 - 1981
Rafael Garcia Villar, Pierre‐Louis Toutain, M. Alvinerie, Y. Ruckebusch
The pharmacokinetic disposition of xylazine hydrochloride is described after both intravenous and intramuscular injection of a single dose, in four domestic species: horse, cattle, sheep and dog, by an original high performance liquid chromatographic technique. Remarkably small interspecific differences are reported. After intravenous administration, systemic half‐life (t... hiện toàn bộ Pharmacokinetics of florfenicol in veal calves Tập 9 Số 4 - Trang 412-425 - 1986
K.J. Varma, Patrick Adams, Thomas F. Powers, Jean D. Powers, J. F. Lamendola
Varma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F. Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9, 412–425.The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22‐mg/kg dose intravenously, orally after a 12‐h fast a...... hiện toàn bộ Pharmacokinetics and anesthetic activity of eugenol in male Sprague–Dawley rats Tập 29 Số 4 - Trang 265-270 - 2006
Sarah Annie Guénette, Francis Beaudry, Jean‐François Marier, Pascal Vachon
Eugenol, the principle chemical constituent of clove oil, has recently been evaluated for its anesthetic and analgesic properties in fish and amphibians. The objective of this study was to determine the pharmacokinetic (PK) and anesthetic activity of eugenol in rats. Male Sprague–Dawley rats received single i.v. doses of eugenol (0, 5, 10, 20, 40 and 60 mg/kg) and anesthetic level was eval...... hiện toàn bộ Pharmacokinetics of enrofloxacin in fingerling rainbow trout (Oncorhynchus mykiss) Tập 15 Số 1 - Trang 62-71 - 1992
Paul R. Bowser, Gregory A. Wooster, Judy St. Leger, John G. Babish
The pharmacokinetics of intravenously and orally administered enrofloxacin was determined in fingerling rainbow trout (Oncorhymhur mykiss). Doses of 5 or 10 mg enrofloxacin /kg body weight were administered intravenously to 26 fish for each dose and blood was sampled over a 60‐h period at 15°C. Two groups of fish were treated orally with 5, 10, or 50 mg/kg (80 fi...... hiện toàn bộ Dược động học, tác dụng dược lý và ảnh hưởng hành vi của acepromazine trên ngựa Dịch bởi AI Tập 5 Số 1 - Trang 21-31 - 1982
Steve Ballard, Theodore Shults, A. A. Kownacki, J W Blake, Thomas Tobin
Sau khi tiêm tĩnh mạch (i.v.), acepromazine được phân bố rộng rãi trong ngựa (Vd= 6,6 lít/kg) và gắn chặt (>99%) vào protein huyết tương. Mức độ của thuốc trong huyết tương giảm xuống với pha α có thời gian bán thải là 4,2 phút, trong khi pha β hoặc thời gian bán thải là 184,8 phút. Ở mức liều 0,3 mg/kg, acepromazine có thể được phát hiện tro...... hiện toàn bộ #acepromazine #ngựa #dược động học #phản ứng dược lý #đào thải #bộ phận sinh dục #hồng cầu #nghiên cứu động vật