Journal of Veterinary Pharmacology and Therapeutics
SCIE-ISI SCOPUS (1978-2023)
0140-7783
1365-2885
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
PharmacologyVeterinary (miscellaneous)
Các bài báo tiêu biểu
Xylazine – a review of its pharmacology and use in veterinary medicine
Tập 11 Số 4 - Trang 295-313 - 1988
Plasma terminal half‐lifeTerminal plasma half‐life is the time required to divide the plasma concentration by two after reaching pseudo‐equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half‐life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limi... ...
Tập 27 Số 6 - Trang 427-439 - 2004
Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogsThe clinical effects and pharmacokinetics of medetomidine (MED) and its enanti‐omers, dexmedetomidine (DEX) and levomedetomidine (LEVO) were compared in a group of six beagle dogs. The dogs received intravenously (i.v.) a bolus of MED (40 μg/kg), DEX (20 and 10 μg/kg), LEVO (20 and 10 μg/kg), and saline placebo in a blinded, randomized block study in six separate sessions. Sedation and ana... ...
Tập 23 Số 1 - Trang 15-20 - 2000
Plasma clearancePlasma (total, systemic…) clearance is determined by all the individual metabolizing/eliminating organ clearances and involves mainly liver and kidney clearances. Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level. The interpret... ...
Tập 27 Số 6 - Trang 415-425 - 2004
The pharmacokinetics of xylazine hydrochloride: an interspecific studyThe pharmacokinetic disposition of xylazine hydrochloride is described after both intravenous and intramuscular injection of a single dose, in four domestic species: horse, cattle, sheep and dog, by an original high performance liquid chromatographic technique. Remarkably small interspecific differences are reported. After intravenous administration, systemic half‐life (t...
Tập 4 Số 2 - Trang 87-92 - 1981
Pharmacokinetics of florfenicol in veal calvesVarma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F. Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9 , 412–425. The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22‐mg/kg dose intravenously, orally after a 12‐h fast a... ...
Tập 9 Số 4 - Trang 412-425 - 1986
Pharmacokinetics of enrofloxacin in fingerling rainbow trout (Oncorhynchus mykiss)The pharmacokinetics of intravenously and orally administered enrofloxacin was determined in fingerling rainbow trout (Oncorhymhur mykiss ). Doses of 5 or 10 mg enrofloxacin /kg body weight were administered intravenously to 26 fish for each dose and blood was sampled over a 60‐h period at 15°C. Two groups of fish were treated orally with 5, 10, or 50 mg/kg (80 fi... ...
Tập 15 Số 1 - Trang 62-71 - 1992
Pharmacokinetics and anesthetic activity of eugenol in male Sprague–Dawley ratsEugenol, the principle chemical constituent of clove oil, has recently been evaluated for its anesthetic and analgesic properties in fish and amphibians. The objective of this study was to determine the pharmacokinetic (PK) and anesthetic activity of eugenol in rats. Male Sprague–Dawley rats received single i.v. doses of eugenol (0, 5, 10, 20, 40 and 60 mg/kg) and anesthetic level was eval... ...
Tập 29 Số 4 - Trang 265-270 - 2006
Mathematical modeling and simulation in animal health – Part II : principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessmentThis review provides a tutorial for individuals interested in quantitative veterinary pharmacology and toxicology and offers a basis for establishing guidelines for physiologically based pharmacokinetic (PBPK ) model development and application in veterinary medicine. This is important as the application of ...
Tập 39 Số 5 - Trang 421-438 - 2016
Principles of pharmacodynamics and their applications in veterinary pharmacologyPharmacodynamics (PDs) is the science of drug action on the body or on microorganisms and other parasites within or on the body. It may be studied at many organizational levels – sub‐molecular, molecular, cellular, tissue/organ and whole body – using in vivo , ex vivo and in vitro methods and utilizing a wide r... ...
Tập 27 Số 6 - Trang 397-414 - 2004