Journal of Veterinary Pharmacology and Therapeutics
SCIE-ISI SCOPUS (1978-2025)
0140-7783
1365-2885
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
PharmacologyVeterinary (miscellaneous)
Các bài báo tiêu biểu
Xylazine – a review of its pharmacology and use in veterinary medicine
Tập 11 Số 4 - Trang 295-313 - 1988
Plasma terminal half‐life
Tập 27 Số 6 - Trang 427-439 - 2004
Terminal plasma half‐life is the time required to divide the plasma
concentration by two after reaching pseudo‐equilibrium, and not the time
required to eliminate half the administered dose. When the process of absorption
is not a limiting factor, half‐life is a hybrid parameter controlled by plasma
clearance and extent of distribution. In contrast, when the process of
absorption is a limiting fac...
Clinical effects and pharmacokinetics of medetomidine and its enantiomers in dogs
Tập 23 Số 1 - Trang 15-20 - 2000
The clinical effects and pharmacokinetics of medetomidine (MED) and its
enanti‐omers, dexmedetomidine (DEX) and levomedetomidine (LEVO) were compared in
a group of six beagle dogs. The dogs received intravenously (i.v.) a bolus of
MED (40 μg/kg), DEX (20 and 10 μg/kg), LEVO (20 and 10 μg/kg), and saline
placebo in a blinded, randomized block study in six separate sessions. Sedation
and analgesia w...
Plasma clearance
Tập 27 Số 6 - Trang 415-425 - 2004
Plasma (total, systemic…) clearance is determined by all the individual
metabolizing/eliminating organ clearances and involves mainly liver and kidney
clearances. Plasma clearance (a volume per time, i.e. a flow) expresses the
overall ability of the body to eliminate a drug by scaling the drug elimination
rate (amount per time) by the corresponding plasma concentration level. The
interpretation of...
The pharmacokinetics of xylazine hydrochloride: an interspecific study
Tập 4 Số 2 - Trang 87-92 - 1981
The pharmacokinetic disposition of xylazine hydrochloride is described after
both intravenous and intramuscular injection of a single dose, in four domestic
species: horse, cattle, sheep and dog, by an original high performance liquid
chromatographic technique. Remarkably small interspecific differences are
reported. After intravenous administration, systemic half‐life (t1/2 β) ranged
between 22 m...
Pharmacokinetics of florfenicol in veal calves
Tập 9 Số 4 - Trang 412-425 - 1986
Varma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F.
Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9,
412–425.The pharmacokinetic disposition of florfenicol was described in veal
calves after administration of a single 22‐mg/kg dose intravenously, orally
after a 12‐h fast and orally 5 min post feeding. Both serum concentrations and
urinary excretion w...
Pharmacokinetics and anesthetic activity of eugenol in male Sprague–Dawley rats
Tập 29 Số 4 - Trang 265-270 - 2006
Eugenol, the principle chemical constituent of clove oil, has recently been
evaluated for its anesthetic and analgesic properties in fish and amphibians.
The objective of this study was to determine the pharmacokinetic (PK) and
anesthetic activity of eugenol in rats. Male Sprague–Dawley rats received single
i.v. doses of eugenol (0, 5, 10, 20, 40 and 60 mg/kg) and anesthetic level was
evaluated wi...
Pharmacokinetics of enrofloxacin in fingerling rainbow trout (Oncorhynchus mykiss)
Tập 15 Số 1 - Trang 62-71 - 1992
The pharmacokinetics of intravenously and orally administered enrofloxacin was
determined in fingerling rainbow trout (Oncorhymhur mykiss). Doses of 5 or 10 mg
enrofloxacin /kg body weight were administered intravenously to 26 fish for each
dose and blood was sampled over a 60‐h period at 15°C. Two groups of fish were
treated orally with 5, 10, or 50 mg/kg (80 fish/dose at each temperature) and
he...
Mathematical modeling and simulation in animal health – Part II : principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment
Tập 39 Số 5 - Trang 421-438 - 2016
This review provides a tutorial for individuals interested in quantitative
veterinary pharmacology and toxicology and offers a basis for establishing
guidelines for physiologically based pharmacokinetic (PBPK) model development
and application in veterinary medicine. This is important as the application of
PBPK modeling in veterinary medicine has evolved over the past two decades. PBPK
models can ...
Dược động học, tác dụng dược lý và ảnh hưởng hành vi của acepromazine trên ngựa Dịch bởi AI
Tập 5 Số 1 - Trang 21-31 - 1982
Sau khi tiêm tĩnh mạch (i.v.), acepromazine được phân bố rộng rãi trong ngựa
(Vd= 6,6 lít/kg) và gắn chặt (>99%) vào protein huyết tương. Mức độ của thuốc
trong huyết tương giảm xuống với pha α có thời gian bán thải là 4,2 phút, trong
khi pha β hoặc thời gian bán thải là 184,8 phút. Ở mức liều 0,3 mg/kg,
acepromazine có thể được phát hiện trong huyết tương trong 8 giờ sau khi dùng
thuốc. Sự phân c...
#acepromazine #ngựa #dược động học #phản ứng dược lý #đào thải #bộ phận sinh dục #hồng cầu #nghiên cứu động vật