The influence of the rumen on the absorption of drugs: studies using meclofenamic acid administered by various routes to sheep and cattle

Journal of Veterinary Pharmacology and Therapeutics - Tập 2 Số 2 - Trang 109-115 - 1979
S. E. Marriner1, J. Bogan1
1Department of Veterinary Pharmacology, University of Glasgow Veterinary School, Bearsden Road, Bearsden, Glasgow

Tóm tắt

As part of a general study of the pharmacokinetics of drugs in the ruminant animal, the absorption and distribution kinetics of meclofenamic acid between the gastro‐intestinal tract and plasma of sheep and cattle were investigated. Meclofenamic acid is a non‐steroidal anti‐inflammatory drug which has been shown to possess anti‐anaphylactic activity in cattle (Aitken & Sanford, 1969; 1972; Wells, Eyre & Lumsden, 1973) and sheep (Alexander, Eyre, Head & Sanford, 1970) and although marketed only for the horse in the United Kingdom (Arquel, Warner‐Lambert) is known to be used in ruminant animals as an anti‐inflammatory drug, for its inhibitory effects on prostaglandin synthesis (Smith G. G. A. 1977, personal communication) and for its anti‐pyretic action (Van Miert, Van der Wal‐Komproe & Van Duin, 1977). The aims of the study were first to evaluate the contribution of reticular (oesophageal) groove closure in directing orally administered drug directly to the abomasum and to assess the rate of absorption through the ruminal epithelium. Second, since Aitken & Sanford (1975) have described the plasma levels of meclofenamate after administration of sodium meclofenamate to cattle by the oral, intravenous and intra‐ruminal routes, it was decided to complement their study and to measure the plasma levels after intra‐muscular injection of sodium meclofenamate. This route is more convenient in cattle than the oral and intravenous routes examined by them. Lastly, the biphasic pattern of plasma levels of meclofenamate observed by Aitken & Sanford (1975) following oral administration of sodium meclofenamate to cattle was further examined using weaned and unweaned calves in an attempt to confirm their view that some of the drug is delivered to the abomasum directly, by‐passing the rumen, by closure of the reticular groove.

Từ khóa


Tài liệu tham khảo

10.1038/223314a0

10.1016/0021-9975(72)90003-5

10.1016/S0034-5288(18)33496-9

10.1016/0021-9975(70)90027-7

Austin F., 1967, Absorption distribution and excretion of sulfonamides in ruminants, Federation Proceedings, 26, 1001

Baggott J. D., 1977, Principles of‐Drug Disposition in Domestic Animals

Dobson A., 1967, Physiological peculiarities of the ruminant relevant to drug distribution, Federation Proceedings, 26, 994

10.1136/vr.101.12.249-a

10.1080/00480169.1977.34421

Glazko A. J.(1966) InFenamates in MedicineEd.P. HumeKendall p.23. Supplement to Annals of Physical Medicine A Symposium London.

Jenkins W. L., 1975, Transfer of drugs across the ruminal wall in goats, American Journal of Veterinary Research, 36, 1771

10.1016/S0034-5288(18)33281-8

10.1136/vr.101.4.81

10.1136/vr.102.14.314

Miert A. S. J. P. A. M., 1977, Effects of antipyretic agents on fever and ruminal stasis induced by endotoxins in conscious goats, Archives internationales de Pharmacodynamie, 225, 39

Ørskov E. R.(1972)Technology of feeding so that the rumen is by‐passed following artificial rearing. InProceedings of the World Congress on Animal Feeding pp.627–640 Madrid.

10.1111/j.1751-0813.1954.tb08152.x

Stowe C. M., 1967, Comparative therapeutics in large domestic animals, Federation Proceedings, 26, 1244

Wells P. W., 1973, Haematological and pathological changes in acute systemic anaphylaxis in calves: effects of pharmacological agents, Canadian Journal of Comparative Medicine, 37, 119

Wester J., 1930, Berliner tierarztliche Wockenschrift, 397

Thông tin
Thông tin xuất bản

Journal of Veterinary Pharmacology and Therapeutics

Tập 2 Số 2

109-115

Thông tin tác giả