Antinociceptive activity and mechanism of action of detomidine

Journal of Veterinary Pharmacology and Therapeutics - Tập 9 Số 3 - Trang 286-292 - 1986
Raimo Virtanen1
1Farmos Group Limited, Research Center, Turku, Finland

Tóm tắt

The antinociceptive activity and mechanism of action of detomidine, a novel sedative‐analgesic, were studied in mice and rats. Xylazine and morphine were included in the studies for comparison. In both acetic acid‐induced writhing test in mice, and in tail flick test in rats, detomidine had potent, dose‐dependent antinociceptive effects with ED50 values of 0.06 and 0.2 mg/kg i.p., respectively. Both xylazine and morphine were clearly less potent than detomidine in these tests. The antinociceptive effect of detomidine was only inhibited by alpha‐2 antagonists (idazoxan, rauwolscine), which suggests that this action is mediated through stimulation of alpha‐2 adrenoceptors. The significance of these Findings for the use of detomidine in veterinary medicine is discussed.

Từ khóa


Tài liệu tham khảo

D'Amour F.E., 1941, A method for determining loss of pain sensation, The Journal of Pharmacology and Experimental Therapeutics, 72, 74

Fielding S., 1981, Psychopharmacology of Clonidine, 225

10.1016/S0140-6736(78)90699-2

Hamra D., 1984, Sedation and analgesia in horses treated with various doses of Domosedan: blind studies on efficacy and the duration of effects, Proceedings of the 30th Convention of American Association of Equine Practitioners, Dallas, 1984, 235

Hayes A.G., 1984, Antagonism of a‐adrenoceptor‐mediated antinociception in the rat, British Journal of Pharmacology, 81, 58p

10.1159/000137388

Lowe J.E., 1984, Analgesic and sedative effects of detomidine in a colic model: blind studies of efficacy and duration of effects, Proceedings of the 30th Convention of American Association of Equine Practitioners, Dallas, 1984, 225

Luttinger D., 1985, Pharmacological analysis of alpha‐2 adrenergic mechanisms in nociception and ataxia, The Journal of Pharmacology and Experimental Therapeutics, 232, 883

10.1007/BF00498581

Paalzow G., 1982, Separate noradrenergic receptors could mediate clonidine induced antinociception, The Journal of Pharmacology and Experimental Therapeutics, 223, 795

Reddy R, 1980, Spinal cord pharmacology of adrenergic agonist‐mediated antinociception, The Journal of Pharmacology and Experimental Therapeutics, 213, 525

10.1016/0028-3908(74)90113-0

10.1016/0014-2999(82)90642-2

10.1016/0014-2999(85)90721-6

10.1111/j.1365-2885.1985.tb00921.x

Wood P.L., 1984, Analgesics: Neurochemical, Behavioural and Clinical Perspectives

Thông tin
Thông tin xuất bản

Journal of Veterinary Pharmacology and Therapeutics

Tập 9 Số 3

286-292

Thông tin tác giả