Influence of closure of the reticular groove on the bioavailability and disposition kinetics of meclofenamate in sheep

Journal of Veterinary Pharmacology and Therapeutics - Tập 19 Số 1 - Trang 15-21 - 1996
Teresa Encinas1, E. Vinagre1, Juan Carlos Boggio1, M. D. San Andrés1, Casilda Rodríguez1, M. I. San Andrés1
1Cátedra de Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Spain

Tóm tắt

Sodium meclofenamate is a non‐steroidal anti‐inflammatory drug with anaphylactic protective activity in cattle. The objectives of this study were to describe the pharmacokinetic behaviour of sodium meclofenamate after intravenous and oral administration to sheep and to determine the influence of closure of the reticular groove on the bioavailability of the drug. Sodium meclofenamate was administered by the intravenous (2.2 mg/kg) and oral (20 mg/kg) routes to sheep (n = 6). During the oral study the reticular groove was closed by intravenous administration of lysine vasopressin (0.3 IU/kg) or left open (saline solution). The closure of the reticular groove was assessed by determination of the blood glucose curves after oral administration of a glucose solution. After intravenous administration of meclofenamate, the distribution and elimination half‐lives of the drug were 7.2 min and 542 min respectively, Vss was 1.68 L/kg and ClB was 2.47 mL/min kg. Two different patterns of the plasma concentration curves were observed after oral administration of sodium meclofenamate. When the reticular groove was closed, two peaks were observed (tmax‐2 12‐15 min, Cmax‐1 3.30‐24.01 μg/mL; and tmax‐2′, 52.50‐75 min, Cmax‐2′ 6.45‐11.08 μg/mL).

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Thông tin xuất bản

Journal of Veterinary Pharmacology and Therapeutics

Tập 19 Số 1

15-21

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