Journal of Pathology
SCOPUS (1969-2023)SCIE-ISI
1096-9896
0022-3417
Anh Quốc
Cơ quản chủ quản: WILEY , John Wiley and Sons Ltd
Lĩnh vực:
Pathology and Forensic Medicine
Các bài báo tiêu biểu
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisAbstract Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS‐CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin‐converting enzyme 2 (ACE2) has been identified as the functional receptor for SARS‐CoV. Although ACE2 mR... ... hiện toàn bộ
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Cellular and molecular mechanisms of fibrosisAbstract Fibrosis is defined by the overgrowth, hardening, and/or scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical ins... ... hiện toàn bộ
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Autophagy: cellular and molecular mechanismsAbstract Autophagy is a self‐degradative process that is important for balancing sources of energy at critical times in development and in response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria, endoplasmic reticulum and peroxisomes, as well as eliminating ... ... hiện toàn bộ
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Macrophage plasticity and polarization in tissue repair and remodellingAbstract Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2 ‐like activation mode. Ma...
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The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapiesAbstract The role of macrophages in tumour growth and development is complex and multifaceted. Whilst there is limited evidence that tumour‐associated macrophages (TAMs) can be directly tumouricidal and stimulate the anti‐tumour activity of T cells, there is now contrasting evidence that tumour cells are able to block or evade the activity of TAMs at the tumour site... ... hiện toàn bộ
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TNF‐mediated inflammatory diseaseAbstract TNF was originally described as a circulating factor that can cause necrosis of tumours, but has since been identified as a key regulator of the inflammatory response. This review describes the known signalling pathways and cell biological effects of TNF, and our understanding of the role of TNF in human disease. TNF interacts with two different receptors, ... ... hiện toàn bộ
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Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesisAbstract In glucocorticoid‐treated rat thymocytes and the murine lymphoid cell lines L5178 and S49 the morphology of apoptosis is associated with chromatin cleavage. The cleavage is at internucleosomal sites, apparently through activation of an endogenous endonuclease. In variants of the cell lines selected for resistance to glucocorticoid, neither apoptosis nor chr... ... hiện toàn bộ
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The myofibroblast in wound healing and fibrocontractive diseasesAbstract The demonstration that fibroblastic cells acquire contractile features during the healing of an open wound, thus modulating into myofibroblasts, has open a new perspective in the understanding of mechanisms leading to wound closure and fibrocontractive diseases. Myofibroblasts synthesize extracellular matrix components such as collagen types I and III and d... ... hiện toàn bộ
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Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine
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Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndromeAbstract Inflammatory response leading to organ dysfunction and failure continues to be the major problem after injury in many clinical conditions such as sepsis, severe burns, acute pancreatitis, haemorrhagic shock, and trauma. In general terms, systemic inflammatory response syndrome (SIRS) is an entirely normal response to injury. Systemic leukocyte activation, h... ... hiện toàn bộ
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