Journal of Pathology

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The dynamic roles of TGF‐β in cancer
Journal of Pathology - Tập 223 Số 2 - Trang 206-219 - 2011
Erik Meulmeester, Peter ten Dijke
AbstractThe transforming growth factor‐β (TGF‐β) signalling pathway plays a critical and dual role in the progression of human cancer. During the early phase of tumour progression, TGF‐β acts as a tumour suppressor, exemplified by deletions or mutations in the core components of the TGF‐β signalling pathway. On the contrary, TGF‐β also promotes processes that suppo...... hiện toàn bộ
Expression of coronin‐3 (coronin‐1C) in diffuse gliomas is related to malignancy
Journal of Pathology - Tập 214 Số 4 - Trang 415-424 - 2008
Dietmar Rudolf Thal, C‐P Xavier, André Rosentreter, Stefan Linder, B. Friedrichs, Andreas Waha, Torsten Pietsch, Maria Stumpf, Noegel Aa, CS Clemen
AbstractCoronin‐3 (coronin‐1C), a homotrimeric F‐actin binding protein, has been shown to be important for cell migration and brain morphogenesis. Here, we present for the first time a detailed analysis of the expression pattern of coronin‐3 in human brain tumours and demonstrate that coronin‐3 expression correlates with malignant phenotype in diffuse gliomas. In g...... hiện toàn bộ
HPV‐mediated cervical carcinogenesis: concepts and clinical implications
Journal of Pathology - Tập 208 Số 2 - Trang 152-164 - 2006
Peter J.F. Snijders, Renske D.M. Steenbergen, Daniëlle A.M. Heideman, Chris J.L.M. Meijer
AbstractPersistent infection with a high‐risk human papillomavirus (hrHPV) is generally accepted as a necessary cause of cervical cancer. However, cervical cancer is a rare complication of an hrHPV infection since most such infections are transient, not even giving rise to cervical lesions. On average, it takes 12–15 years before a persistent hrHPV infection may ul...... hiện toàn bộ
Human atherosclerotic plaques express DC‐SIGN, a novel protein found on dendritic cells and macrophages
Journal of Pathology - Tập 198 Số 4 - Trang 511-516 - 2002
Elizabeth J. Soilleux, LS Morris, John Trowsdale, Nicholas Coleman, JJ Boyle
AbstractThe association of autoimmune phenomena with atherosclerosis suggests that plaques may contain specialized antigen‐presenting cells, dendritic cells (DCs). DC‐SIGN is a C‐type lectin expressed by DCs. This study assessed whether human atherosclerotic plaques expressed DC‐SIGN and several other macrophage/DC markers. Plaques from human coronary and carotid a...... hiện toàn bộ
Epigenetics and Chromatin Remodeling in Adult Cardiomyopathy
Journal of Pathology - Tập 231 Số 2 - Trang 147-157 - 2013
Salma Awad, Coralie Poizat
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional‐based study
Journal of Pathology - Tập 223 Số 3 - Trang 327-335 - 2011
Nadège Presneau, Asem Shalaby, Hongtao Ye, Nischalan Pillay, Dina Halai, Bernadine Idowu, Roberto Tirabosco, Duncan Whitwell, Thomas S. Jacques, Lars‐Gunnar Kindblom, Silke Brüderlein, Peter Möller, Andreas Leithner, Bernadette Liegl, Fernanda Amary, Nicholas N Athanasou, Pancras C.W. Hogendoorn, Fredrik Mertens, Károly Szuhai, Adrienne M. Flanagan
AbstractA variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplificatio...... hiện toàn bộ
Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas
Journal of Pathology - Tập 209 Số 2 - Trang 157-165 - 2006
Sonja Vujović, Stephen Henderson, Nadège Presneau, Edward Odell, TS Jacques, Roberto Tirabosco, Chris Boshoff, Adrienne M. Flanagan
Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis
Journal of Pathology - Tập 203 Số 2 - Trang 631-637 - 2004
Inge Hamming, Wim Timens, MLC Bulthuis, A. Titia Lely, G. Navis, Harry van Goor
AbstractSevere acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS‐CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin‐converting enzyme 2 (ACE2) has been identified as the functional receptor for SARS‐CoV. Although ACE2 mR...... hiện toàn bộ
The chemokine system and cancer
Journal of Pathology - Tập 226 Số 2 - Trang 148-157 - 2012
Frances R. Balkwill
AbstractChemokines (chemo‐attractant cytokines) are a group of small proteins that act together with their cell surface receptors, in development, normal physiology and immune responses, to direct cells to specific locations throughout the body. Cancer cells acquire the ability to subvert the chemokine system, such that these molecules and their receptors become im...... hiện toàn bộ
Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine
Journal of Pathology - Tập 104 Số 1 - Trang 15-29 - 1971
Michelino Di Rosa, J. P. Giroud, D. A. Willoughby
Tổng số: 148   
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