Journal of Pathology

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Immunosenescence of ageing
Journal of Pathology - Tập 211 Số 2 - Trang 144-156 - 2007
AL Gruver, LL Hudson, Gregory D. Sempowski
AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function. The thymus is a central lymphoid organ responsi...... hiện toàn bộ
KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas
Journal of Pathology - Tập 202 Số 3 - Trang 375-381 - 2004
Chin‐Chen Pan, Paul Chih‐Hsueh Chen, Hung Chiang
AbstractKIT (CD117), a tyrosine kinase receptor, has not been widely studied in epithelial tumours. In a systematic immunohistochemical survey of KIT expression on tissue arrays incorporating 671 cases, it was found that thymic carcinomas frequently express KIT. Twenty‐two thymic carcinomas, 110 thymomas, and 16 non‐neoplastic thymus glands were retrieved for furth...... hiện toàn bộ
Expression of luminal and basal cytokeratins in human breast carcinoma
Journal of Pathology - Tập 203 Số 2 - Trang 661-671 - 2004
Dalia M. Abd El‐Rehim, Sarah Pinder, Claire E. Paish, Joshua A. Bell, Ian O. Ellis, J.F.R. Robertson, Robert I. Nicholson
AbstractWe have examined basal and luminal cell cytokeratin expression in 1944 cases of invasive breast carcinoma, using tissue microarray (TMA) technology, to determine the frequency of expression of each cytokeratin subtype, their relationships and prognostic relevance, if any. Expression was determined by immunocytochemistry staining using antibodies to the lumi...... hiện toàn bộ
Macrophage plasticity and polarization in tissue repair and remodelling
Journal of Pathology - Tập 229 Số 2 - Trang 176-185 - 2013
Alberto Mantovani, Subhra K. Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati
AbstractMononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2‐like activation mode. Ma...... hiện toàn bộ
Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts
Journal of Pathology - Tập 212 Số 2 - Trang 180-187 - 2007
M. J. Chung, T Liu, Matt Ullenbruch, Sem H. Phan
AbstractMyofibroblasts play an essential role in the abnormal deposition of extracellular matrix in pulmonary fibrosis. The presence or prolonged survival of these cells may be a key factor in the pathogenesis of progressive pulmonary fibrosis. Found in inflammatory zone (FIZZ)1 can induce myofibroblast differentiation and has an antiapoptotic effect on embryonic l...... hiện toàn bộ
Augmented gp130‐mediated cytokine signalling accompanies human gastric cancer progression
Journal of Pathology - Tập 213 Số 2 - Trang 140-151 - 2007
CB Jackson, Louise M. Judd, Trevelyan R. Menheniott, Ian Kronborg, Chris Dow, Neville D. Yeomans, Alex Boussioutas, Lorraine Robb, AS Giraud
AbstractH. pylori infection accounts for most cases of gastric cancer, but the initiating events remain unclear. The principal H. pylori pathogenicity‐associated CagA protein disrupts intracellular SHP‐2 signalling pathways including those used by the IL‐6 family cytokines, IL‐6 and IL‐11. Imbalanced IL‐6 family...... hiện toàn bộ
Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammation
Journal of Pathology - Tập 207 Số 1 - Trang 43-52 - 2005
TV Franic, Ian R. van Driel, Paul A. Gleeson, AS Giraud, Louise M. Judd
AbstractH+/K+‐ATPase β‐subunit‐deficient mice (129/Sv background) display numerous pathologies in the stomach. Expression of the mutation in BALB/cCrSlc mice results in the development of an aberrant ‘mucus‐rich’ cell population. ‘Mucus‐rich’ cells have been described in stomachs of mice with autoimmune gastritis, a disease...... hiện toàn bộ
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
Journal of Pathology - Tập 239 Số 1 - Trang 72-83 - 2016
Zheming Lu, Jindong Sheng, Yujie Zhang, Jianhua Deng, Yong Li, Aiping Lü, Juan Zhang, Huan Yu, Min Zhang, Zikai Xiong, Hai Yan, Bill H. Diplas, Youyong Lu, Baoguo Liu
Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra‐glandular spread of the initial neoplastic clone
Journal of Pathology - Tập 215 Số 2 - Trang 145-154 - 2008
Ivan Jovanović, Brett Delahunt, Bryan McIver, Norman L. Eberhardt, Stefan K. Grebe
AbstractPapillary thyroid carcinoma (PTC) is frequently multifocal (mPTC), with synchronous tumour foci often showing varied morphology. The genetic mechanisms underlying the development of multiple and histologically diverse tumour foci remain uncertain. Different tumour foci might develop either through intrathyroidal dissemination of a single malignant clone, wi...... hiện toàn bộ
Role of tissue stroma in cancer cell invasion
Journal of Pathology - Tập 200 Số 4 - Trang 429-447 - 2003
Olivier De Wever, Marc Mareel
AbstractMaintenance of epithelial tissues needs the stroma. When the epithelium changes, the stroma inevitably follows. In cancer, changes in the stroma drive invasion and metastasis, the hallmarks of malignancy. Stromal changes at the invasion front include the appearance of myofibroblasts, cells sharing characteristics with fibroblasts and smooth muscle cells. Th...... hiện toàn bộ
Tổng số: 147   
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