Journal of Pathology

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What have animal models taught us about the p53 pathway?
Journal of Pathology - Tập 205 Số 2 - Trang 206-220 - 2005
Guillermina Lozano, Gerard P. Zambetti
AbstractMouse models have provided important insight into the in vivo significance of upstream and downstream signals that regulate the p53 tumour suppressor. One important lesson learned from these models is that negative regulators of p53 are critical in vivo modulators of p53 activi...... hiện toàn bộ
Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease
Journal of Pathology - Tập 231 Số 3 - Trang 273-289 - 2013
Rafael Kramann, Derek P. DiRocco, Benjamin D. Humphreys
Tenascins: regulation and putative functions during pathological stress
Journal of Pathology - Tập 200 Số 4 - Trang 488-499 - 2003
Ruth Chiquet‐Ehrismann, Matthias Chiquet
AbstractIn this review, we discuss the structure and function of the extracellular matrix protein family of tenascins with emphasis on their involvement in human pathologies. The article is divided into the following sections: Introduction: the tenascin family of extracellular matrix proteins; Structural roles: tenascin‐X deficiency and Ehlers–Danlos syndrome; Tenascins as modulators of cell adhesion, migration, and growth; hiện toàn bộ
The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma
Journal of Pathology - Tập 172 Số 2 - Trang 183-187 - 1994
Michael Jeffers, Gerard M. O'Dowd, Hugh Mulcahy, M. Patrick Stagg, Diarmuid O’Donoghue, Mary Toner
AbstractMicrometastases have been detected by immunocytochemical means in the lymph nodes of patients with otherwise node‐negative cancer of the colon and rectum. This study examines the incidence and prognostic significance of nodal micrometastases in Dukes' B carcinoma. Five hundred and fifty‐nine lymph nodes from 77 cases of Dukes' B carcinoma were examined for ...... hiện toàn bộ
T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse
Journal of Pathology - Tập 213 Số 2 - Trang 229-238 - 2007
Andrea Farini, Mirella Meregalli, M. Belicchi, Maurizio Battistelli, D. Parolini, Giuseppe D’Antona, Manuela Gavina, Linda Ottoboni, Gabriela Constantin, Roberto Bottinelli, Yvan Torrente
AbstractAbnormal connective tissue proliferation following muscle degeneration is a major pathological feature of Duchenne muscular dystrophy (DMD), a genetic myopathy due to lack of the sarcolemmal dystrophin protein. Since this fibrotic proliferation is likely to be a major obstacle to the efficacy of future therapies, research is needed to understand and prevent...... hiện toàn bộ
Immunosenescence of ageing
Journal of Pathology - Tập 211 Số 2 - Trang 144-156 - 2007
AL Gruver, LL Hudson, Gregory D. Sempowski
AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function. The thymus is a central lymphoid organ responsi...... hiện toàn bộ
KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas
Journal of Pathology - Tập 202 Số 3 - Trang 375-381 - 2004
Chin‐Chen Pan, Paul Chih‐Hsueh Chen, Hung Chiang
AbstractKIT (CD117), a tyrosine kinase receptor, has not been widely studied in epithelial tumours. In a systematic immunohistochemical survey of KIT expression on tissue arrays incorporating 671 cases, it was found that thymic carcinomas frequently express KIT. Twenty‐two thymic carcinomas, 110 thymomas, and 16 non‐neoplastic thymus glands were retrieved for furth...... hiện toàn bộ
Expression of luminal and basal cytokeratins in human breast carcinoma
Journal of Pathology - Tập 203 Số 2 - Trang 661-671 - 2004
Dalia M. Abd El‐Rehim, Sarah Pinder, Claire E. Paish, Joshua A. Bell, Ian O. Ellis, J.F.R. Robertson, Robert I. Nicholson
AbstractWe have examined basal and luminal cell cytokeratin expression in 1944 cases of invasive breast carcinoma, using tissue microarray (TMA) technology, to determine the frequency of expression of each cytokeratin subtype, their relationships and prognostic relevance, if any. Expression was determined by immunocytochemistry staining using antibodies to the lumi...... hiện toàn bộ
Macrophage plasticity and polarization in tissue repair and remodelling
Journal of Pathology - Tập 229 Số 2 - Trang 176-185 - 2013
Alberto Mantovani, Subhra K. Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati
AbstractMononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2‐like activation mode. Ma...... hiện toàn bộ
Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts
Journal of Pathology - Tập 212 Số 2 - Trang 180-187 - 2007
M. J. Chung, T Liu, Matt Ullenbruch, Sem H. Phan
AbstractMyofibroblasts play an essential role in the abnormal deposition of extracellular matrix in pulmonary fibrosis. The presence or prolonged survival of these cells may be a key factor in the pathogenesis of progressive pulmonary fibrosis. Found in inflammatory zone (FIZZ)1 can induce myofibroblast differentiation and has an antiapoptotic effect on embryonic l...... hiện toàn bộ
Tổng số: 148   
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