Journal of Pathology

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Immunosenescence of ageing
Journal of Pathology - Tập 211 Số 2 - Trang 144-156 - 2007
AL Gruver, LL Hudson, Gregory D. Sempowski
AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function. The thymus is a central lymphoid organ responsi...... hiện toàn bộ
Macrophage plasticity and polarization in tissue repair and remodelling
Journal of Pathology - Tập 229 Số 2 - Trang 176-185 - 2013
Alberto Mantovani, Subhra K. Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati
AbstractMononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2‐like activation mode. Ma...... hiện toàn bộ
Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts
Journal of Pathology - Tập 212 Số 2 - Trang 180-187 - 2007
M. J. Chung, T Liu, Matt Ullenbruch, Sem H. Phan
AbstractMyofibroblasts play an essential role in the abnormal deposition of extracellular matrix in pulmonary fibrosis. The presence or prolonged survival of these cells may be a key factor in the pathogenesis of progressive pulmonary fibrosis. Found in inflammatory zone (FIZZ)1 can induce myofibroblast differentiation and has an antiapoptotic effect on embryonic l...... hiện toàn bộ
Augmented gp130‐mediated cytokine signalling accompanies human gastric cancer progression
Journal of Pathology - Tập 213 Số 2 - Trang 140-151 - 2007
CB Jackson, Louise M. Judd, Trevelyan R. Menheniott, Ian Kronborg, Chris Dow, Neville D. Yeomans, Alex Boussioutas, Lorraine Robb, AS Giraud
AbstractH. pylori infection accounts for most cases of gastric cancer, but the initiating events remain unclear. The principal H. pylori pathogenicity‐associated CagA protein disrupts intracellular SHP‐2 signalling pathways including those used by the IL‐6 family cytokines, IL‐6 and IL‐11. Imbalanced IL‐6 family...... hiện toàn bộ
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
Journal of Pathology - Tập 239 Số 1 - Trang 72-83 - 2016
Zheming Lu, Jindong Sheng, Yujie Zhang, Jianhua Deng, Yong Li, Aiping Lü, Juan Zhang, Huan Yu, Min Zhang, Zikai Xiong, Hai Yan, Bill H. Diplas, Youyong Lu, Baoguo Liu
A potentially dynamic lysosomal role for the endogenous TRPML proteins
Journal of Pathology - Tập 219 Số 2 - Trang 153-162 - 2009
David A. Zeevi, Ayala Frumkin, Vered Offen‐Glasner, Aviram Kogot‐Levin, Gideon Bach
AbstractLysosomal storage disorders (LSDs) constitute a diverse group of inherited diseases that result from lysosomal storage of compounds occurring in direct consequence to deficiencies of proteins implicated in proper lysosomal function. Pathology in the LSD mucolipidosis type IV (MLIV), is characterized by lysosomal storage of lipids together with water‐soluble...... hiện toàn bộ
TNF‐mediated inflammatory disease
Journal of Pathology - Tập 214 Số 2 - Trang 149-160 - 2008
John R. Bradley
AbstractTNF was originally described as a circulating factor that can cause necrosis of tumours, but has since been identified as a key regulator of the inflammatory response. This review describes the known signalling pathways and cell biological effects of TNF, and our understanding of the role of TNF in human disease. TNF interacts with two different receptors, ...... hiện toàn bộ
α‐Actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study
Journal of Pathology - Tập 199 Số 3 - Trang 387-397 - 2003
Albert J.H. Suurmeijer, Sophie Clément, Arianna Francesconi, Leonardo Bocchi, Annalisa Angelini, Dirk J. van Veldhuisen, Luigi Giusto Spagnoli, Giulio Gabbiani, Augusto Orlandi
AbstractWe investigated the distribution of α‐skeletal, α‐cardiac, and α‐smooth muscle actin isoforms in human heart during development, hypertrophy, and failure. At 20 weeks of fetal life, α‐skeletal actin was localized in a small proportion of subendocardial and papillary muscle cardiomyocytes. At this gestation time, diffuse α‐cardiac actin staining was observed...... hiện toàn bộ
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type
Journal of Pathology - Tập 238 Số 3 - Trang 389-400 - 2016
Anthony N. Karnezis, Yemin Wang, Pilar Ramos, William P.D. Hendricks, Esther Oliva, Emanuela D’Angelo, Jaime Prat, Marisa R. Nucci, Torsten O. Nielsen, Christine Chow, Samuel Leung, Friedrich Kommoss, Stefan Kommoss, Annacarolina da Silva, Brigitte M. Ronnett, Joseph T. Rabban, David D.L. Bowtell, Bernard E. Weissman, Jeffrey M. Trent, C. Blake Gilks, David G. Huntsman
AbstractSmall cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is a lethal and sometimes familial ovarian tumour of young women and children. We and others recently discovered that over 90% of SCCOHTs harbour inactivating mutations in...... hiện toàn bộ
Pulmonary hypoplasia in babies with severe rhesus isoimmunisation: A quantitative study
Journal of Pathology - Tập 122 Số 1 - Trang 43-52 - 1977
David G. Chamberlain, Alison A. Hislop, Edmund Hey, Lynne Reid
Tổng số: 148   
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