Journal of Pathology

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Immunosenescence of ageing
Journal of Pathology - Tập 211 Số 2 - Trang 144-156 - 2007
AL Gruver, LL Hudson, Gregory D. Sempowski
AbstractAgeing is a complex process that negatively impacts the development of the immune system and its ability to function. The mechanisms that underlie these age‐related defects are broad and range from defects in the haematopoietic bone marrow to defects in peripheral lymphocyte migration, maturation and function. The thymus is a central lymphoid organ responsi...... hiện toàn bộ
Macrophage plasticity and polarization in tissue repair and remodelling
Journal of Pathology - Tập 229 Số 2 - Trang 176-185 - 2013
Alberto Mantovani, Subhra K. Biswas, Maria Rosaria Galdiero, Antonio Sica, Massimo Locati
AbstractMononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2‐like activation mode. Ma...... hiện toàn bộ
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
Journal of Pathology - Tập 239 Số 1 - Trang 72-83 - 2016
Zheming Lu, Jindong Sheng, Yujie Zhang, Jianhua Deng, Yong Li, Aiping Lü, Juan Zhang, Huan Yu, Min Zhang, Zikai Xiong, Hai Yan, Bill H. Diplas, Youyong Lu, Baoguo Liu
TNF‐mediated inflammatory disease
Journal of Pathology - Tập 214 Số 2 - Trang 149-160 - 2008
John R. Bradley
AbstractTNF was originally described as a circulating factor that can cause necrosis of tumours, but has since been identified as a key regulator of the inflammatory response. This review describes the known signalling pathways and cell biological effects of TNF, and our understanding of the role of TNF in human disease. TNF interacts with two different receptors, ...... hiện toàn bộ
α‐Actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study
Journal of Pathology - Tập 199 Số 3 - Trang 387-397 - 2003
Albert J.H. Suurmeijer, Sophie Clément, Arianna Francesconi, Leonardo Bocchi, Annalisa Angelini, Dirk J. van Veldhuisen, Luigi Giusto Spagnoli, Giulio Gabbiani, Augusto Orlandi
AbstractWe investigated the distribution of α‐skeletal, α‐cardiac, and α‐smooth muscle actin isoforms in human heart during development, hypertrophy, and failure. At 20 weeks of fetal life, α‐skeletal actin was localized in a small proportion of subendocardial and papillary muscle cardiomyocytes. At this gestation time, diffuse α‐cardiac actin staining was observed...... hiện toàn bộ
Short‐term rhythmic proliferation of human breast cancer cell lines: surface effects and fractal growth patterns
Journal of Pathology - Tập 197 Số 2 - Trang 163-169 - 2002
Roland Sedivy, Stefan Thurner, Alexandra C. Budinsky, Wolfgang J. Köstler, Christoph Zielinski
AbstractKinetic studies of cell proliferation rates shed light on the growth dynamics of cancer. Most such studies are based on measurements of cell numbers that were evaluated in time intervals of about 12 h. Studies of the initial tumour growth with short measuring intervals are rare. This study was therefore designed with 1 h measuring intervals over a 24 h peri...... hiện toàn bộ
MicroRNA‐542‐3p inhibits tumour angiogenesis by targeting Angiopoietin‐2
Journal of Pathology - Tập 232 Số 5 - Trang 499-508 - 2014
Ting He, Feifei Qi, Lin Jia, Shan Wang, Nan Song, Lifang Guo, Yan Fu, Yongzhang Luo
AbstractAngiopoietin‐2 (Angpt2) plays a critical role in angiogenesis and tumour progression. Therapeutic targeting of Angpt2 has been implicated as a promising strategy for cancer treatment. Whereas miRNAs are emerging as important modulators of angiogenesis, regulation of Angpt2 by ... hiện toàn bộ
Histogenesis of granular cell tumour—an immunohistochemical and ultrastructural study
Journal of Pathology - Tập 142 Số 3 - Trang 221-229 - 1984
Markku Miettinen, Eero Lehtonen, Hannu Lehtola, Peter Ekblom, Veli‐Pekka Lehto, Ismo Virtanen
AbstractFifteen cases of granular cell tumour of superficial soft tissues or tongue were immunohistochemically evaluated for different types of intermediate filament proteins and for laminin, a glycoprotein of basal laminae. Four of the tumours were studied ultrastructurally. The tumour cells appeared to contain only vimentin‐type of intermediate filament protein. ...... hiện toàn bộ
Genome‐wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target
Journal of Pathology - Tập 227 Số 2 - Trang 146-156 - 2012
Marco Gerlinger, Cláudio R. Santos, Bradley Spencer‐Dene, Pierre Martinez, David Endesfelder, Rebecca A. Burrell, Marcus Vetter, Ming Jiang, Rebecca E. Saunders, Gavin Kelly, Karl Dykema, Nathalie Rioux‐Leclercq, Gordon Stamp, Jean‐Jacques Patard, James Larkin, Michael Howell, Charles Swanton
AbstractClear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome‐wide RNA interference screen for ccRCC survival regulators with an analysis of recurrently overexpressed genes in ccRCC to identify new therapeutic targets in this disease. One of the most potent survival regulators, the m...... hiện toàn bộ
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional‐based study
Journal of Pathology - Tập 223 Số 3 - Trang 327-335 - 2011
Nadège Presneau, Asem Shalaby, Hongtao Ye, Nischalan Pillay, Dina Halai, Bernadine Idowu, Roberto Tirabosco, Duncan Whitwell, Thomas S. Jacques, Lars‐Gunnar Kindblom, Silke Brüderlein, Peter Möller, Andreas Leithner, Bernadette Liegl, Fernanda Amary, Nicholas N Athanasou, Pancras C.W. Hogendoorn, Fredrik Mertens, Károly Szuhai, Adrienne M. Flanagan
AbstractA variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplificatio...... hiện toàn bộ
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