The myofibroblast in wound healing and fibrocontractive diseases

Journal of Pathology - Tập 200 Số 4 - Trang 500-503 - 2003
Giulio Gabbiani1
1Department of Pathology, CMU University of Geneva, Switzerland

Tóm tắt

AbstractThe demonstration that fibroblastic cells acquire contractile features during the healing of an open wound, thus modulating into myofibroblasts, has open a new perspective in the understanding of mechanisms leading to wound closure and fibrocontractive diseases. Myofibroblasts synthesize extracellular matrix components such as collagen types I and III and during normal wound healing disappear by apoptosis when epithelialization occurs. The transition from fibroblasts to myofibroblasts is influenced by mechanical stress, TGF‐β and cellular fibronectin (ED‐A splice variant). These factors also play important roles in the development of fibrocontractive changes, such as those observed in liver cirrhosis, renal fibrosis, and stroma reaction to epithelial tumours. Copyright © 2003 John Wiley & Sons, Ltd.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Pathology

Tập 200 Số 4

500-503

Thông tin tác giả