Inhibition of AP‐1 transcription activator induces myc‐dependent apoptosis in HL60 cellsJournal of Cellular Biochemistry - Tập 91 Số 5 - Trang 973-986 - 2004
Seyeon Park, Eun‐Ryeong Hahm, Dug‐Keun Lee, Chul‐Hak Yang
AbstractTranscriptional activation of AP‐1 is intricately involved in cell proliferation and transformation. The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP‐1 protein to the AP‐1 site in 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated HL60 cells. The NDGA inhibits the auto‐re...... hiện toàn bộ
In situ hybridization of putative somatostatin mRNA within hypothalamus of the rat using synthetic oligonucleotide probesJournal of Cellular Biochemistry - Tập 27 Số 4 - Trang 415-422 - 1985
R. Arentzen, Frank Baldino, Leonard G. Davis, Gerald A. Higgins, Lin Yuan, Robert Manning, B. Wolfson
AbstractThe distribution of mRNA with high sequence homology to somatostatin mRNA within the periventricular hypothalamus of rat was assessed using in situ hybridization techniques with synthetic oligodeoxyribonucleotide probes, complementary to the 3′ coding region of rat somatostatin mRNA. The probes (22‐ and 24‐mers) were 5′‐end labeled using T4 polynucleotide k...... hiện toàn bộ
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?Journal of Cellular Biochemistry - Tập 101 Số 4 - Trang 830-839 - 2007
Derek C. Radisky, Paraic A. Kenny, Mina J. Bissell
AbstractMyofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and pro‐inflammatory factors, and stimulate epithelial cell proliferation and invasion. Myofibroblasts are normally induced transiently during wound healing, but inappropriate induction of myofibroblasts causes organ fibrosis, which greatly enhances the risk of subsequent c...... hiện toàn bộ
Applications of immortalized cells in basic and clinical neurologyJournal of Cellular Biochemistry - Tập 45 Số 3 - Trang 279-283 - 1991
Herbert M. Geller, Vanya Quiñ ones‐Jenab, Maciej Półtorak, William J. Freed
AbstractImmortalized cell lines can serve as model systems for studies of neuronal development and restoration of function in models of neurological disease. Cell lines which result from spontaneous or experimentally‐induced tumors have been used for these purposes. More recently, the techniques of genetic engineering have resulted in the production of cell lines w...... hiện toàn bộ
Fluid flow induces Rankl expression in primary murine calvarial osteoblastsJournal of Cellular Biochemistry - Tập 98 Số 5 - Trang 1271-1283 - 2006
Meenal Mehrotra, Masatomo Saegusa, Sunil Wadhwa, Olga Voznesensky, Donald R. Peterson, Carol C. Pilbeam
AbstractMechanical loading of bone generates fluid flow within the mineralized matrix that exerts fluid shear stress (FSS) on cells. We examined effects of FSS on receptor activator of nuclear factor κ B ligand (RANKL), a critical factor for osteoclast formation. Primary murine osteoblasts were subjected to pulsatile FSS (5 Hz, 10 dynes/cm2) fo...... hiện toàn bộ
Fluorescence decay kinetics of chlorophyll in photosynthetic membranesJournal of Cellular Biochemistry - Tập 23 Số 1-4 - Trang 131-158 - 1983
Kerry K. Karukstis, Kenneth Sauer
AbstractThe absorption of light by the pigments of photosynthetic organisms results in electronic excitation that provides the energy to drive the energy‐storing light reactions. A small fraction of this excitation gives rise to fluorescence emission, which serves as a sensitive probe of the energetics and kinetics of the excited states. The wavelength dependence o...... hiện toàn bộ
High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) DistributionJournal of Cellular Biochemistry - Tập 118 Số 12 - Trang 4317-4322 - 2017
Seyed‐Amir Tabatabaeizadeh, Amir Avan, Afsane Bahrami, Ezzat Khodashenas, Habibollah Esmaily, Gordon A. Ferns, Mojtaba Fattahi Abdizadeh, Majid Ghayour‐Mobarhan
ABSTRACTThe prevalence of Vitamin D deficiency is increasing worldwide, which has be shown to be associated with increased risk of cardiovascular disease (CVD), autoimmune disease, and metabolic syndrome. These conditions are also associated with a heightened state of inflammation. The aim of the current study was to evaluate the effect of v...... hiện toàn bộ
Location, location, location: The role of cyclin D1 nuclear localization in cancerJournal of Cellular Biochemistry - Tập 96 Số 5 - Trang 906-913 - 2005
Andrew B. Gladden, J. Alan Diehl
AbstractThe control of cell proliferation is crucial in maintaining cellular homeostasis and loss of this mechanism is a principle hallmark of cancer cells. A primary target of growth factor signaling is the cyclin D1‐dependent kinase (D1‐CDK4/6) whose activity promotes G1 phase progression by phosphorylating the retinoblastoma protein (Rb) alo...... hiện toàn bộ