Journal of Cellular Biochemistry
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Expression of miR‐486‐5p and its significance in lung squamous cell carcinoma
Journal of Cellular Biochemistry - Tập 120 Số 8 - Trang 13912-13923 - 2019
AbstractLung squamous cell carcinoma (LUSC) is one of the main histological
types of lung cancer with high mortality. The role of microRNA‐486‐5p in LUSC
remains unclear. In the current study, the aim was to explore miR‐486‐5p
expression and its role in LUSC. The miR‐486‐5p expression was significantly
low‐expressed in patients with LUSC from The Cancer Genome Atlas database, which
was further con...
Role of miR‐486‐5p in regulating renal cell carcinoma cell proliferation and apoptosis via TGF‐β–activated kinase 1
Journal of Cellular Biochemistry - Tập 120 Số 3 - Trang 2954-2963 - 2019
AbstractRenal cell carcinoma (RCC) is a common kidney tumor in adults. The role
of miR‐486‐5p in RCC is unknown. The aim of our study was to identify new
targets regulated by miR‐486‐5p in RCC, to obtain a deeper insight into the
network and to better understand the role of these microRNAs and their targets
in carcinogenesis of RCC. We performed a series of tests and found consistently
lower expre...
FGF2 promotes Msx2 stimulated PC‐1 expression via Frs2/MAPK signaling
Journal of Cellular Biochemistry - Tập 111 Số 5 - Trang 1346-1358 - 2010
AbstractPC‐1 is an enzymatic generator of pyrophosphate and a critical regulator
of tissue mineralization. We previously showed that fibroblast growth factor‐2
(FGF2) specifically induces PC‐1 expression in calvarial pre‐osteoblasts and
that this occurs via a transcriptional mechanism involving Runx2. Because
aberrant FGF signaling and Msx2 activity result in similar craniofacial skeletal
defects ...
Inhibition of AP‐1 transcription activator induces myc‐dependent apoptosis in HL60 cells
Journal of Cellular Biochemistry - Tập 91 Số 5 - Trang 973-986 - 2004
AbstractTranscriptional activation of AP‐1 is intricately involved in cell
proliferation and transformation. The natural product, nordihydroguaiaretic acid
(NDGA) shows an inhibitory effect on the binding of jun/AP‐1 protein to the AP‐1
site in 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated HL60 cells. The
NDGA inhibits the auto‐regulated de novo synthesis of c‐jun mRNA in
TPA‐stimulated HL...
In situ hybridization of putative somatostatin mRNA within hypothalamus of the rat using synthetic oligonucleotide probes
Journal of Cellular Biochemistry - Tập 27 Số 4 - Trang 415-422 - 1985
AbstractThe distribution of mRNA with high sequence homology to somatostatin
mRNA within the periventricular hypothalamus of rat was assessed using in situ
hybridization techniques with synthetic oligodeoxyribonucleotide probes,
complementary to the 3′ coding region of rat somatostatin mRNA. The probes (22‐
and 24‐mers) were 5′‐end labeled using T4 polynucleotide kinase and γ‐32P‐ATP.
They were us...
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
Journal of Cellular Biochemistry - Tập 101 Số 4 - Trang 830-839 - 2007
AbstractMyofibroblasts produce and modify the extracellular matrix (ECM),
secrete angiogenic and pro‐inflammatory factors, and stimulate epithelial cell
proliferation and invasion. Myofibroblasts are normally induced transiently
during wound healing, but inappropriate induction of myofibroblasts causes organ
fibrosis, which greatly enhances the risk of subsequent cancer development. As
myofibrobla...
Biosynthesis of lysosomal endopeptidases
Journal of Cellular Biochemistry - Tập 40 Số 1 - Trang 31-41 - 1989
AbstractDespite the clear differences between the amino acid sequence and
enzymatic specificity of aspartic and cysteine endopeptidases, the biosynthetic
processing of lysosomal members of these two families is very similar. With in
vitro translation and pulse‐chase analysis in tissue culture cells, the
biosynthesis of cathepsin D, a aspartic protease, and cathepsins B, H and L,
cysteine proteases...
Investigation of structural stability and functionality of homodimeric gramicidin towards peptide‐based drug: a molecular simulation approach
Journal of Cellular Biochemistry - Tập 120 Số 4 - Trang 4903-4911 - 2019
AbstractIncreasing death rates due to antibiotic resistance deteriorate the
existing treatment measures. Antimicrobial peptides have turned into the
emerging cure for multidrug resistance. However, the stability and functionality
determine an antimicrobial peptide as a drug. Analyses of the homodimeric
β‐helical peptide, gramicidin have suggested the significant role of
gramicidin‐A, gramicidin‐B,...
Applications of immortalized cells in basic and clinical neurology
Journal of Cellular Biochemistry - Tập 45 Số 3 - Trang 279-283 - 1991
AbstractImmortalized cell lines can serve as model systems for studies of
neuronal development and restoration of function in models of neurological
disease. Cell lines which result from spontaneous or experimentally‐induced
tumors have been used for these purposes. More recently, the techniques of
genetic engineering have resulted in the production of cell lines with specific
desired characterist...
MicroRNA‐150 Protects Against Pressure Overload‐Induced Cardiac Hypertrophy
Journal of Cellular Biochemistry - Tập 116 Số 10 - Trang 2166-2176 - 2015
ABSTRACTCardiac hypertrophy is the response of the heart to a variety of
hypertrophic stimuli; this condition progresses to heart failure and sudden
death. MicroRNAs (miRs) are a family of small, non‐coding RNAs that mediate
posttranscriptional gene silencing. Recent studies have identified miRs as
important regulators in cardiac hypertrophy. One specific miR, miR‐150 has been
reported to be downr...
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