Journal of Cellular Biochemistry

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Expression of miR‐486‐5p and its significance in lung squamous cell carcinoma
Journal of Cellular Biochemistry - Tập 120 Số 8 - Trang 13912-13923 - 2019
Sheng Yang, Jing Sui, Tong Liu, Wenjuan Wu, Siyi Xu, Ying Zhang, Yuepu Pu, Xiaomei Zhang, Yan Zhang, Bo Shen, Geyu Liang
AbstractLung squamous cell carcinoma (LUSC) is one of the main histological types of lung cancer with high mortality. The role of microRNA‐486‐5p in LUSC remains unclear. In the current study, the aim was to explore miR‐486‐5p expression and its role in LUSC. The miR‐486‐5p expression was significantly low‐expressed in patients with LUSC from The Cancer Genome Atla...... hiện toàn bộ
Role of miR‐486‐5p in regulating renal cell carcinoma cell proliferation and apoptosis via TGF‐β–activated kinase 1
Journal of Cellular Biochemistry - Tập 120 Số 3 - Trang 2954-2963 - 2019
Yanfa He, Jianzhen Liu, Yongjun Wang, Xiaoli Zhu, Zhengchao Fan, Chongbin Li, Hang Yin, Ying Liu
AbstractRenal cell carcinoma (RCC) is a common kidney tumor in adults. The role of miR‐486‐5p in RCC is unknown. The aim of our study was to identify new targets regulated by miR‐486‐5p in RCC, to obtain a deeper insight into the network and to better understand the role of these microRNAs and their targets in carcinogenesis of RCC. We performed a series of tests a...... hiện toàn bộ
FGF2 promotes Msx2 stimulated PC‐1 expression via Frs2/MAPK signaling
Journal of Cellular Biochemistry - Tập 111 Số 5 - Trang 1346-1358 - 2010
Yan Li, Jin Liu, Mark P. Hudson, Sung‐Su Kim, Nan Hatch
AbstractPC‐1 is an enzymatic generator of pyrophosphate and a critical regulator of tissue mineralization. We previously showed that fibroblast growth factor‐2 (FGF2) specifically induces PC‐1 expression in calvarial pre‐osteoblasts and that this occurs via a transcriptional mechanism involving Runx2. Because aberrant FGF signaling and Msx2 activity result in simil...... hiện toàn bộ
Inhibition of AP‐1 transcription activator induces myc‐dependent apoptosis in HL60 cells
Journal of Cellular Biochemistry - Tập 91 Số 5 - Trang 973-986 - 2004
Seyeon Park, Eun‐Ryeong Hahm, Dug‐Keun Lee, Chul‐Hak Yang
AbstractTranscriptional activation of AP‐1 is intricately involved in cell proliferation and transformation. The natural product, nordihydroguaiaretic acid (NDGA) shows an inhibitory effect on the binding of jun/AP‐1 protein to the AP‐1 site in 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated HL60 cells. The NDGA inhibits the auto‐re...... hiện toàn bộ
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
Journal of Cellular Biochemistry - Tập 101 Số 4 - Trang 830-839 - 2007
Derek C. Radisky, Paraic A. Kenny, Mina J. Bissell
AbstractMyofibroblasts produce and modify the extracellular matrix (ECM), secrete angiogenic and pro‐inflammatory factors, and stimulate epithelial cell proliferation and invasion. Myofibroblasts are normally induced transiently during wound healing, but inappropriate induction of myofibroblasts causes organ fibrosis, which greatly enhances the risk of subsequent c...... hiện toàn bộ
Biosynthesis of lysosomal endopeptidases
Journal of Cellular Biochemistry - Tập 40 Số 1 - Trang 31-41 - 1989
Ann H. Erickson
AbstractDespite the clear differences between the amino acid sequence and enzymatic specificity of aspartic and cysteine endopeptidases, the biosynthetic processing of lysosomal members of these two families is very similar. With in vitro translation and pulse‐chase analysis in tissue culture cells, the biosynthesis of cathepsin D, a aspartic protease, and cathepsi...... hiện toàn bộ
Investigation of structural stability and functionality of homodimeric gramicidin towards peptide‐based drug: a molecular simulation approach
Journal of Cellular Biochemistry - Tập 120 Số 4 - Trang 4903-4911 - 2019
P. Ganesan, R. Rajasekaran
AbstractIncreasing death rates due to antibiotic resistance deteriorate the existing treatment measures. Antimicrobial peptides have turned into the emerging cure for multidrug resistance. However, the stability and functionality determine an antimicrobial peptide as a drug. Analyses of the homodimeric β‐helical peptide, gramicidin have suggested the significant ro...... hiện toàn bộ
Applications of immortalized cells in basic and clinical neurology
Journal of Cellular Biochemistry - Tập 45 Số 3 - Trang 279-283 - 1991
Herbert M. Geller, Vanya Quiñ ones‐Jenab, Maciej Półtorak, William J. Freed
AbstractImmortalized cell lines can serve as model systems for studies of neuronal development and restoration of function in models of neurological disease. Cell lines which result from spontaneous or experimentally‐induced tumors have been used for these purposes. More recently, the techniques of genetic engineering have resulted in the production of cell lines w...... hiện toàn bộ
MicroRNA‐150 Protects Against Pressure Overload‐Induced Cardiac Hypertrophy
Journal of Cellular Biochemistry - Tập 116 Số 10 - Trang 2166-2176 - 2015
Wanli Liu, Yu Liu, Yan Zhang, Xueyong Zhu, Rui Zhang, Lihua Guan, Qizhu Tang, Hong Jiang, Congxin Huang, He Huang
ABSTRACTCardiac hypertrophy is the response of the heart to a variety of hypertrophic stimuli; this condition progresses to heart failure and sudden death. MicroRNAs (miRs) are a family of small, non‐coding RNAs that mediate posttranscriptional gene silencing. Recent studies have identified miRs as important regulators in cardiac hypertrophy...... hiện toàn bộ
Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors
Journal of Cellular Biochemistry - Tập 99 Số 4 - Trang 1165-1174 - 2006
Andrey E. Belous, Christopher M. Jones, Aya Wakata, Clayton D. Knox, Ian B. Nicoud, Janene Pierce, Ravi S. Chari
Tổng số: 184   
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