Applications of immortalized cells in basic and clinical neurology

Journal of Cellular Biochemistry - Tập 45 Số 3 - Trang 279-283 - 1991
Herbert M. Geller1, Vanya Quiñ ones‐Jenab2, Maciej Półtorak3, William J. Freed3
1Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway 08854.
2Department of Pharmacology, UMDNJ‐Robert Wood Johnson Medical School and The Graduate School, Rutgers University, Piscataway, New Jersey 08854
3NIMH Neurosciences Center, St. Elizabeth's Hospital, Washington, D.C.

Tóm tắt

AbstractImmortalized cell lines can serve as model systems for studies of neuronal development and restoration of function in models of neurological disease. Cell lines which result from spontaneous or experimentally‐induced tumors have been used for these purposes. More recently, the techniques of genetic engineering have resulted in the production of cell lines with specific desired characteristics. This has been accomplished by insertion of a desired gene into a pre‐existing immortal cell or by immortalizing primary cells. The production of immortal cell lines using temperature‐sensitive immortalizing genes offers an additional method of controlling gene expression, and thereby controlling cell proliferation and differentation. In the nervous system, these techniques have produced immortal cell lines with neuronal and glial properties.

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Thông tin xuất bản

Journal of Cellular Biochemistry

Tập 45 Số 3

279-283

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