Journal of Cell Science

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N-linked glycosylation plays a crucial role in the secretion of HMGB1
Journal of Cell Science - Tập 129 Số 1 - Trang 29-38 - 2016
Young Hun Kim, Man Sup Kwak, Jun Bae Park, Shin Ae Lee, Jieun Choi, Hyun‐Soo Cho, Jeon‐Soo Shin
ABSTRACT HMGB1 protein is a delayed mediator of sepsis that is secreted to the extracellular milieu in response to various stimulants, inducing a pro-inflammatory response. HMGB1 is devoid of an endoplasmic reticulum (ER)-targeting signal peptide; hence, the mechanism of extracellular secretion is not completely understood, although HMGB1 is secreted after being subjected to post-translational mod... hiện toàn bộ
Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion
Journal of Cell Science - Tập 108 Số 11 - Trang 3473-3483 - 1995
Guojuan Liao, Takayuki Nagasaki, Gregg G. Gundersen
ABSTRACT The role of microtubules (MTs) in cell locomotion is uncertain: while MTs are not essential for motility of certain cells, MTs are necessary for the directed translocation of large cells such as fibroblasts, endothelial cells and neuronal growth cones. Based on previous studies, we hypothesize that cell locomotion may involve MTs in two possible ways: (1) the rate of cell locomotion is pr... hiện toàn bộ
WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexes
Journal of Cell Science - Tập 124 Số 23 - Trang 3967-3979 - 2011
Birija Sankar Patro, Rikke Frøhlich, Vilhelm A. Bohr, Tinna Stevnsner
Checkpoints are cellular surveillance and signaling pathways that coordinate the response to DNA damage and replicative stress. Consequently, failure of cellular checkpoints increases susceptibility to DNA damage and can lead to profound genome instability. This study examines the role of a human RECQ helicase, WRN, in checkpoint activation in response to DNA damage. Mutations in WRN lead to genom... hiện toàn bộ
Biochemical investigation of protein export in Escherichia coli
Journal of Cell Science - Tập 1989 Số Supplement_11 - Trang 29-43 - 1989
Simon J. S. Hardy, Linda L. Randall
ABSTRACT Export of proteins from the bacterial cytoplasm to a final destination in the periplasm and outer membrane is one example of the fundamental process occurring in all cells whereby polypeptides are transferred across biological membranes. Investigations on a variety of different systems have indicated similarities in the mechanism of this process. In the cases of bacterial protein export a... hiện toàn bộ
Adhesion signaling – crosstalk between integrins, Src and Rho
Journal of Cell Science - Tập 122 Số 8 - Trang 1059-1069 - 2009
Stephan Huveneers, Erik H.J. Danen
Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth fact... hiện toàn bộ
Mitochondrial and nucleocytoplasmic targeting of O-linked GlcNAc transferase
Journal of Cell Science - Tập 116 Số 4 - Trang 647-654 - 2003
Dona C. Love, Jarema Kochran, R. Lamont Cathey, Sanghoon Shin, John A. Hanover
O-linked GlcNAc transferase (OGT) mediates a novel glycan-dependent signaling pathway, but the intracellular targeting of OGT is poorly understood. We examined the localization of OGT by immunofluorescence microscopy, subcellular fractionation and immunoblotting using highly specific affinity-purified antisera. In addition to the expected nuclear localization,we found that OGT was highly concentra... hiện toàn bộ
CD133, a novel marker for human prostatic epithelial stem cells
Journal of Cell Science - Tập 117 Số 16 - Trang 3539-3545 - 2004
Gavin D. Richardson, Craig Robson, Shona Lang, David E. Neal, Norman J. Maitland, Anne T. Collins
Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restrict... hiện toàn bộ
On mammary stem cells
Journal of Cell Science - Tập 118 Số 16 - Trang 3585-3594 - 2005
Wendy A. Woodward, Mercy S. Chen, Fariba Behbod, Jeffrey M. Rosen
Mammary gland stem cells are a quiescent and self-renewing population within the mammary gland that are capable of giving rise to the differentiated ductal, alveolar and myoepithelial cells. To identify mammary gland stem cells, several investigators have employed a variety of methods including: non-adherent mammosphere cultures; 5-bromo-2-deoxy-uridine (BrdU) label-retention studies; cell-surface... hiện toàn bộ
The cell surface of Trypanosoma cruzi: cytochemistry and freeze-fracture
Journal of Cell Science - Tập 33 Số 1 - Trang 285-299 - 1978
Wanderley de Souza, A. Martfnez-Palomo, Arturo González‐Robles
ABSTRACT The ultrastructure of epimastigotes of Trypanosoma cruzi, obtained from, acellular cultures, and bloodstream trypomastigotes, isolated from infected mice, were studied by thin-sectioning and freeze-fracturing techniques. Epimastigotes showed a thin (5 nm) surface coat when stained with ruthenium red, while the surface coat of trypomastigotes was more prominent (15 nm thick). Both P and E ... hiện toàn bộ
Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells
Journal of Cell Science - Tập 118 Số 13 - Trang 2849-2858 - 2005
Anne‐Marie Marzesco, Peggy Janich, Michaela Wilsch‐Bräuninger, Véronique Dubreuil, Katja Langenfeld, Denis Corbeil, Wieland Β. Huttner
Apical plasma membrane constituents of mammalian neural stem/progenitor cells have recently been implicated in maintaining their stem/progenitor cell state. Here, we report that in the developing embryonic mouse brain, the fluid in the lumen of the neural tube contains membrane particles carrying the stem cell marker prominin-1 (CD133), a pentaspan membrane protein found on membrane protrusions of... hiện toàn bộ
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