Journal of Cell Science

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Low concentrations of nocodazole interfere with fibroblast locomotion without significantly affecting microtubule level: Implications for the role of dynamic microtubules in cell locomotion
Journal of Cell Science - Tập 108 Số 11 - Trang 3473-3483 - 1995
Guojuan Liao, Takayuki Nagasaki, Gregg G. Gundersen
ABSTRACT The role of microtubules (MTs) in cell locomotion is uncertain: while MTs are not essential for motility of certain cells, MTs are necessary for the directed translocation of large cells such as fibroblasts, endothelial cells and neuronal growth cones. Based on previous studies, we hypothesize that cell locomotion may involve MTs in two poss...... hiện toàn bộ
Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts
Journal of Cell Science - Tập 122 Số 19 - Trang 3441-3454 - 2009
William D. Bradley, Anthony J. Koleske
The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton. They transduce diverse extracellular cues into cytoskeletal rearrangements that have dramatic effects on cell motility and morphogenesis. Recent biochemical and genetic studies have revealed several mechanisms that Abl-family kinases use to mediate these effects. Abl-family kinases stimulate actin po...... hiện toàn bộ
Protein kinase B/Akt at a glance
Journal of Cell Science - Tập 118 Số 24 - Trang 5675-5678 - 2005
Elisabeth Fayard, Lionel Tintignac, Betty Lamothe, Brian A. Hemmings
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways
Journal of Cell Science - Tập 117 Số 2 - Trang 257-270 - 2004
Julie Gavard, Mireille Lambert, Inna Grosheva, Véronique Marthiens, Théano Irinopoulou, Jean‐François Riou, Alexander D. Bershadsky, René‐Marc Mège
Cell adhesion molecules of the cadherin family contribute to the regulation of cell shape and fate by mediating strong intercellular adhesion through Ca2+-dependent interaction of their ectodomain and association of their cytoplasmic tail to actin. However, the mechanisms co-ordinating cadherinmediated adhesion with the reorganization of the actin cytoskeleton remain elusive. Here, the for...... hiện toàn bộ
Cyclic ADP-ribose increases Ca2+ removal in smooth muscle
Journal of Cell Science - Tập 116 Số 21 - Trang 4291-4306 - 2003
Karen N. Bradley, Susan Currie, Debbi MacMillan, T C Muir, John G. McCarron
Ca2+ release via ryanodine receptors (RyRs) is vital in cell signalling and regulates diverse activities such as gene expression and excitation-contraction coupling. Cyclic ADP ribose (cADPR), a proposed modulator of RyR activity, releases Ca2+ from the intracellular store in sea urchin eggs but its mechanism of action in other cell types is controversial. In this study, caged cADPR was us...... hiện toàn bộ
Regulation of mTORC1 and its impact on gene expression at a glance
Journal of Cell Science - - 2013
Mathieu Laplante, David M. Sabatini
The mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates key cellular functions linked to the promotion of cell growth and metabolism. This kinase, which is part of two protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), has a fundamental role in coordinating anabolic and catabolic processes in response to growth factors and nutrients. Of the two mT...... hiện toàn bộ
Agonist-induced phasic and tonic responses in smooth muscle are mediated by InsP3
Journal of Cell Science - Tập 115 Số 10 - Trang 2207-2218 - 2002
John G. McCarron, John Craig, Karen N. Bradley, T C Muir
Many cellular functions are regulated by agonist-induced InsP3-evoked Ca2+ release from the internal store. In non-excitable cells, predominantly, the initial Ca2+release from the store by InsP3 is followed by a more sustained elevation in [Ca2+]i via store-operated Ca2+ channels as a consequence of depletion of the store. Here, in smooth muscle, we report that the initial transient increa...... hiện toàn bộ
Migration of human vascular smooth muscle cells involves serum-dependent repeated cytosolic calcium transients
Journal of Cell Science - Tập 113 Số 4 - Trang 653-662 - 2000
Arnaud Scherberich, Manuel Campos‐Toimil, Philippe Rondé, Kenneth Takeda, Alain Beretz
ABSTRACT Migration of vascular smooth muscle cells (VSMC) is a key event in the formation of neointima during atherosclerosis. Fura-2 loaded VSMCs were used to investigate calcium homeostasis during cell migration. Multiple spontaneous transient increases in cytosolic free calcium [Ca2+]iwere observed in single human VSMCs migrating on type I collage...... hiện toàn bộ
RecQ-like helicases: the DNA replication checkpoint connection
Journal of Cell Science - Tập 113 Số 15 - Trang 2641-2646 - 2000
Christian Frei, Susan M. Gasser
ABSTRACT The eukaryotic homologues of the Escherichia coli RecQ DNA helicase play conserved roles in the maintenance of genome stability. Results obtained in yeast and mammalian systems are beginning to form a coherent picture about what these helicases do to ensure normal cell division and why humans who lack these enzymes are cancer prone. Recent d...... hiện toàn bộ
Supercoils in plant DNA: Nucleoid sedimentation studies
Journal of Cell Science - Tập 89 Số 2 - Trang 243-252 - 1988
Roberta Meschini, Jordanka Zlatanova, Anna Vassileva, Maria G. Ivanchenko, Chavdar Krachmarov, Dobri D. Genchev
ABSTRACT Plant nuclei have been studied with respect to the three-dimensional structure of DNA. Nucleoids derived from nuclei by non-ionic detergent and high salt treatment were analysed by sedimentation in a series of sucrose gradients containing increasing amounts of the intercalating agent ethidium bromide. In addition the nucleoid sedimentation b...... hiện toàn bộ
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