Adhesion signaling – crosstalk between integrins, Src and Rho
Tóm tắt
Từ khóa
Tài liệu tham khảo
Allingham, M. J., van Buul, J. D. and Burridge, K. (2007). ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J. Immunol.179, 4053-4064.
Alrutz, M. A. and Isberg, R. R. (1998). Involvement of focal adhesion kinase in invasin-mediated uptake. Proc. Natl. Acad. Sci. USA95, 13658-13663.
Alrutz, M. A., Srivastava, A., Wong, K. W., Souza-Schorey, C., Tang, M., Ch'Ng, L. E., Snapper, S. B. and Isberg, R. R. (2001). Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function. Mol. Microbiol.42, 689-703.
Arias-Salgado, E. G., Lizano, S., Sarkar, S., Brugge, J. S., Ginsberg, M. H. and Shattil, S. J. (2003). Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc. Natl. Acad. Sci. USA100, 13298-13302.
Arias-Salgado, E. G., Lizano, S., Shattil, S. J. and Ginsberg, M. H. (2005). Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J. Biol. Chem.280, 29699-29707.
Arthur, W. T., Petch, L. A. and Burridge, K. (2000). Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr. Biol.10, 719-722.
Ballestrem, C., Hinz, B., Imhof, B. A. and Wehrle-Haller, B. (2001). Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. J. Cell Biol.155, 1319-1332.
Bass, M. D., Morgan, M. R., Roach, K. A., Settleman, J., Goryachev, A. B. and Humphries, M. J. (2008). p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J. Cell Biol.181, 1013-1026.
Bromann, P. A., Korkaya, H. and Courtneidge, S. A. (2004). The interplay between Src family kinases and receptor tyrosine kinases. Oncogene23, 7957-7968.
Brown, M. C., Cary, L. A., Jamieson, J. S., Cooper, J. A. and Turner, C. E. (2005). Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol. Biol. Cell16, 4316-4328.
Bruce-Staskal, P. J., Weidow, C. L., Gibson, J. J. and Bouton, A. H. (2002). Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake. J. Cell Sci.115, 2689-2700.
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A. C., Macara, I. G., Madhani, H., Fink, G. R. and Ravichandran, K. S. (2002). Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat. Cell Biol.4, 574-582.
Carman, C. V., Jun, C. D., Salas, A. and Springer, T. A. (2003). Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J. Immunol.171, 6135-6144.
Carman, C. V., Sage, P. T., Sciuto, T. E., de la Fuente, M. A., Geha, R. S., Ochs, H. D., Dvorak, H. F., Dvorak, A. M. and Springer, T. A. (2007). Transcellular diapedesis is initiated by invasive podosomes. Immunity26, 784-797.
Carragher, N. O., Walker, S. M., Scott Carragher, L. A., Harris, F., Sawyer, T. K., Brunton, V. G., Ozanne, B. W. and Frame, M. C. (2006). Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene25, 5726-5740.
Chellaiah, M. A. (2006). Regulation of podosomes by integrin alphavbeta3 and Rho GTPase-facilitated phosphoinositide signaling. Eur. J. Cell Biol.85, 311-317.
Chodniewicz, D. and Klemke, R. L. (2004). Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim. Biophys. Acta1692, 63-76.
Choma, D. P., Milano, V., Pumiglia, K. M. and DiPersio, C. M. (2007). Integrin alpha3beta1-dependent activation of FAK/Src regulates Rac1-mediated keratinocyte polarization on laminin-5. J. Invest. Dermatol.127, 31-40.
Clark, K., Langeslag, M., Figdor, C. G. and van Leeuwen, F. N. (2007). Myosin II and mechanotransduction: a balancing act. Trends Cell Biol.17, 178-186.
Danen, E. H. and Yamada, K. M. (2001). Fibronectin, integrins, and growth control. J. Cell Physiol.189, 1-13.
Danen, E. H., Sonneveld, P., Brakebusch, C., Fassler, R. and Sonnenberg, A. (2002). The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J. Cell Biol.159, 1071-1086.
Danen, E. H., van Rheenen, J., Franken, W., Huveneers, S., Sonneveld, P., Jalink, K. and Sonnenberg, A. (2005). Integrins control motile strategy through a Rho-cofilin pathway. J. Cell Biol.169, 515-526.
Demali, K. A. and Burridge, K. (2003). Coupling membrane protrusion and cell adhesion. J. Cell Sci.116, 2389-2397.
Dubash, A. D., Wennerberg, K., Garcia-Mata, R., Menold, M. M., Arthur, W. T. and Burridge, K. (2007). A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J. Cell Sci.120, 3989-3998.
Engler, A. J., Sen, S., Sweeney, H. L. and Discher, D. E. (2006). Matrix elasticity directs stem cell lineage specification. Cell126, 677-689.
Faccio, R., Teitelbaum, S. L., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V. L., Ross, F. P. and Swat, W. (2005). Vav3 regulates osteoclast function and bone mass. Nat. Med.11, 284-290.
Feng, Q., Baird, D., Peng, X., Wang, J., Ly, T., Guan, J. L. and Cerione, R. A. (2006). Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat. Cell Biol.8, 945-956.
Feng, X., Novack, D. V., Faccio, R., Ory, D. S., Aya, K., Boyer, M. I., McHugh, K. P., Ross, F. P. and Teitelbaum, S. L. (2001). A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function. J. Clin. Invest107, 1137-1144.
Frame, M. C., Fincham, V. J., Carragher, N. O. and Wyke, J. A. (2002). v-Src's hold over actin and cell adhesions. Nat. Rev. Mol. Cell. Biol.3, 233-245.
Franco, S. J., Rodgers, M. A., Perrin, B. J., Han, J., Bennin, D. A., Critchley, D. R. and Huttenlocher, A. (2004). Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nat. Cell Biol.6, 977-983.
Gaggioli, C., Hooper, S., Hidalgo-Carcedo, C., Grosse, R., Marshall, J. F., Harrington, K. and Sahai, E. (2007). Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat. Cell Biol.9, 1392-1400.
Garcia, A. J., Schwarzbauer, J. E. and Boettiger, D. (2002). Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry41, 9063-9069.
Grande-Garcia, A., Echarri, A., de Rooij, J., Alderson, N. B., Waterman-Storer, C. M., Valdivielso, J. M. and del Pozo, M. A. (2007). Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J. Cell Biol.177, 683-694.
Hamelers, I. H., Olivo, C., Mertens, A. E., Pegtel, D. M., van der Kammen, R. A., Sonnenberg, A. and Collard, J. G. (2005). The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration. J. Cell Biol.171, 871-881.
Honda, H., Nakamoto, T., Sakai, R. and Hirai, H. (1999). p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts. Biochem. Biophys. Res. Commun.262, 25-30.
Huveneers, S., van den Bout, I., Sonneveld, P., Sancho, A., Sonnenberg, A. and Danen, E. H. (2007). Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src. Cancer Res.67, 2693-2700.
Huveneers, S., Arslan, S., van de Water, B., Sonnenberg, A. and Danen, E. H. (2008a). Integrins uncouple Src-induced morphological and oncogenic transformation. J. Biol. Chem.283, 13243-13251.
Huveneers, S., Truong, H., Fassler, R., Sonnenberg, A. and Danen, E. H. (2008b). Binding of soluble fibronectin to integrin {alpha}5{beta}1-link to focal adhesion redistribution and contractile shape. J. Cell Sci.121, 2452-2462.
Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M. and Yamamoto, T. (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature377, 539-544.
Ilic, D., Kovacic, B., Johkura, K., Schlaepfer, D. D., Tomasevic, N., Han, Q., Kim, J. B., Howerton, K., Baumbusch, C., Ogiwara, N. et al. (2004). FAK promotes organization of fibronectin matrix and fibrillar adhesions. J. Cell Sci.117, 177-187.
Im, E. and Kazlauskas, A. (2007). Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J. Biol. Chem.282, 29122-29129.
Jiang, G., Huang, A. H., Cai, Y., Tanase, M. and Sheetz, M. P. (2006). Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha. Biophys. J.90, 1804-1809.
Kinsey, R., Williamson, M. R., Chaudhry, S., Mellody, K. T., McGovern, A., Takahashi, S., Shuttleworth, C. A. and Kielty, C. M. (2008). Fibrillin-1 microfibril deposition is dependent on fibronectin assembly. J. Cell Sci.121, 2696-2704.
Kiosses, W. B., Shattil, S. J., Pampori, N. and Schwartz, M. A. (2001). Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat. Cell Biol.3, 316-320.
Kiyokawa, E., Hashimoto, Y., Kobayashi, S., Sugimura, H., Kurata, T. and Matsuda, M. (1998). Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev.12, 3331-3336.
Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., de Lanerolle, P. and Cheresh, D. A. (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol.137, 481-492.
Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J.18, 2459-2471.
Kostic, A. and Sheetz, M. P. (2006). Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge. Mol. Biol. Cell17, 2684-2695.
Lakkakorpi, P. T., Nakamura, I., Young, M., Lipfert, L., Rodan, G. A. and Duong, L. T. (2001). Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. J. Cell Sci.114, 149-160.
Larsen, M., Artym, V. V., Green, J. A. and Yamada, K. M. (2006). The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr. Opin. Cell Biol.18, 463-471.
Law, D. A., DeGuzman, F. R., Heiser, P., Ministri-Madrid, K., Killeen, N. and Phillips, D. R. (1999). Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function. Nature401, 808-811.
Liang, X., Draghi, N. A. and Resh, M. D. (2004). Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes. J. Neurosci.24, 7140-7149.
Lim, Y., Lim, S. T., Tomar, A., Gardel, M., Bernard-Trifilo, J. A., Chen, X. L., Uryu, S. A., Canete-Soler, R., Zhai, J., Lin, H. et al. (2008). PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J. Cell Biol.180, 187-203.
Liu, Y. and Senger, D. R. (2004). Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells. FASEB J.18, 457-468.
Mammoto, A., Huang, S. and Ingber, D. E. (2007). Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J. Cell Sci.120, 456-467.
Mammoto, A., Mammoto, T. and Ingber, D. E. (2008). Rho signaling and mechanical control of vascular development. Curr. Opin. Hematol.15, 228-234.
Mao, Y. and Schwarzbauer, J. E. (2005). Fibronectin fibrillogenesis, a cell-mediated matrix assembly process. Matrix Biol.24, 389-399.
Marcoux, N. and Vuori, K. (2003). EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2. Oncogene22, 6100-6106.
Margadant, C., Raymond, K., Kreft, M., Sachs, N., Janssen, H. and Sonnenberg, A. (2009). Integrin {alpha}3{beta}1 inhibits directional migration and wound re-epithelialization in the skin. J. Cell Sci.122, 278-288.
Marignani, P. A. and Carpenter, C. L. (2001). Vav2 is required for cell spreading. J. Cell Biol.154, 177-186.
Mariotti, A., Kedeshian, P. A., Dans, M., Curatola, A. M., Gagnoux-Palacios, L. and Giancotti, F. G. (2001). EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J. Cell Biol.155, 447-458.
Matthews, B. D., Overby, D. R., Mannix, R. and Ingber, D. E. (2006). Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J. Cell Sci.119, 508-518.
McHugh, K. P., Hodivala-Dilke, K., Zheng, M. H., Namba, N., Lam, J., Novack, D., Feng, X., Ross, F. P., Hynes, R. O. and Teitelbaum, S. L. (2000). Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts. J. Clin. Invest105, 433-440.
Mejia, E., Bliska, J. B. and Viboud, G. I. (2008). Yersinia controls type III effector delivery into host cells by modulating Rho activity. PLoS. Pathog.4, e3.
Meng, W., Numazaki, M., Takeuchi, K., Uchibori, Y., ndo-Akatsuka, Y., Tominaga, M. and Tominaga, T. (2004). DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner. EMBO J.23, 760-771.
Miao, H., Li, S., Hu, Y. L., Yuan, S., Zhao, Y., Chen, B. P., Puzon-McLaughlin, W., Tarui, T., Shyy, J. Y., Takada, Y. et al. (2002). Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J. Cell Sci.115, 2199-2206.
Mitra, S. K. and Schlaepfer, D. D. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol.18, 516-523.
Moro, L., Dolce, L., Cabodi, S., Bergatto, E., Boeri, E. E., Smeriglio, M., Turco, E., Retta, S. F., Giuffrida, M. G., Venturino, M. et al. (2002). Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J. Biol. Chem.277, 9405-9414.
Nimnual, A. S., Taylor, L. J. and Bar-Sagi, D. (2003). Redox-dependent downregulation of Rho by Rac. Nat. Cell Biol.5, 236-241.
Obergfell, A., Eto, K., Mocsai, A., Buensuceso, C., Moores, S. L., Brugge, J. S., Lowell, C. A. and Shattil, S. J. (2002). Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J. Cell Biol.157, 265-275.
Ohta, Y., Hartwig, J. H. and Stossel, T. P. (2006). FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat. Cell Biol.8, 803-814.
Pankov, R., Cukierman, E., Katz, B. Z., Matsumoto, K., Lin, D. C., Lin, S., Hahn, C. and Yamada, K. M. (2000). Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J. Cell Biol.148, 1075-1090.
Pankov, R., Endo, Y., Even-Ram, S., Araki, M., Clark, K., Cukierman, E., Matsumoto, K. and Yamada, K. M. (2005). A Rac switch regulates random versus directionally persistent cell migration. J. Cell Biol.170, 793-802.
Paszek, M. J., Zahir, N., Johnson, K. R., Lakins, J. N., Rozenberg, G. I., Gefen, A., Reinhart-King, C. A., Margulies, S. S., Dembo, M., Boettiger, D. et al. (2005). Tensional homeostasis and the malignant phenotype. Cancer Cell8, 241-254.
Pelkmans, L., Burli, T., Zerial, M. and Helenius, A. (2004). Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic. Cell118, 767-780.
Puklin-Faucher, E. and Sheetz, M. P. (2009). The mechanical integrin cycle. J. Cell Sci.122, 179-186.
Ren, X. D., Kiosses, W. B., Sieg, D. J., Otey, C. A., Schlaepfer, D. D. and Schwartz, M. A. (2000). Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J. Cell Sci.113, 3673-3678.
Russell, A. J., Fincher, E. F., Millman, L., Smith, R., Vela, V., Waterman, E. A., Dey, C. N., Guide, S., Weaver, V. M. and Marinkovich, M. P. (2003). Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. J. Cell Sci.116, 3543-3556.
Sahai, E. and Marshall, C. J. (2003). Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat. Cell Biol.5, 711-719.
Sandilands, E. and Frame, M. C. (2008). Endosomal trafficking of Src tyrosine kinase. Trends Cell Biol.18, 322-329.
Schober, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F. and Fuchs, E. (2007). Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J. Cell Biol.176, 667-680.
Schoenwaelder, S. M., Hughan, S. C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P. E., Salem, H. H. and Jackson, S. P. (2002). RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear. J. Biol. Chem.277, 14738-14746.
Schramp, M., Ying, O., Kim, T. Y. and Martin, G. S. (2008). ERK5 promotes Src-induced podosome formation by limiting Rho activation. J. Cell Biol.181, 1195-1210.
Servitja, J. M., Marinissen, M. J., Sodhi, A., Bustelo, X. R. and Gutkind, J. S. (2003). Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J. Biol. Chem.278, 34339-34346.
Shattil, S. J. (2005). Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol.15, 399-403.
Soriano, P., Montgomery, C., Geske, R. and Bradley, A. (1991). Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell64, 693-702.
Taniguchi, S., Liu, H., Nakazawa, T., Yokoyama, K., Tezuka, T. and Yamamoto, T. (2003). p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem. Biophys. Res. Commun.306, 151-155.
ten Klooster, J. P., Jaffer, Z. M., Chernoff, J. and Hordijk, P. L. (2006). Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J. Cell Biol.172, 759-769.
Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D. A., Engelhardt, B., Cao, G., DeLisser, H. and Schwartz, M. A. (2005). A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature437, 426-431.
van Buul, J. D., Allingham, M. J., Samson, T., Meller, J., Boulter, E., Garcia-Mata, R. and Burridge, K. (2007). RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J. Cell Biol.178, 1279-1293.
Velling, T., Risteli, J., Wennerberg, K., Mosher, D. F. and Johansson, S. (2002). Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1. J. Biol. Chem.277, 37377-37381.
Vial, E., Sahai, E. and Marshall, C. J. (2003). ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility. Cancer Cell4, 67-79.
Vidal, C., Geny, B., Melle, J., Jandrot-Perrus, M. and Fontenay-Roupie, M. (2002). Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood100, 4462-4469.
Wary, K. K., Mariotti, A., Zurzolo, C. and Giancotti, F. G. (1998). A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell94, 625-634.
Webb, D. J., Parsons, J. T. and Horwitz, A. F. (2002). Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again. Nat. Cell Biol.4, E97-100.
Webb, D. J., Donais, K., Whitmore, L. A., Thomas, S. M., Turner, C. E., Parsons, J. T. and Horwitz, A. F. (2004). FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol.6, 154-161.
White, D. P., Caswell, P. T. and Norman, J. C. (2007). alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J. Cell Biol.177, 515-525.
Wierzbicka-Patynowski, I. and Schwarzbauer, J. E. (2002). Regulatory role for SRC and phosphatidylinositol 3-kinase in initiation of fibronectin matrix assembly. J. Biol. Chem.277, 19703-19708.
Wildenberg, G. A., Dohn, M. R., Carnahan, R. H., Davis, M. A., Lobdell, N. A., Settleman, J. and Reynolds, A. B. (2006). p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell127, 1027-1039.
Wilhelmsen, K., Litjens, S. H., Kuikman, I., Margadant, C., van Rheenen, J. and Sonnenberg, A. (2007). Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol. Biol. Cell18, 3512-3522.
Wolf, K., Mazo, I., Leung, H., Engelke, K., von Andrian, U. H., Deryugina, E. I., Strongin, A. Y., Brocker, E. B. and Friedl, P. (2003). Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol.160, 267-277.
Wolf, R. M., Wilkes, J. J., Chao, M. V. and Resh, M. D. (2001). Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. J. Neurobiol.49, 62-78.
Wong, K. W. and Isberg, R. R. (2005). Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake. Curr. Opin. Microbiol.8, 4-9.
Woodside, D. G., Obergfell, A., Leng, L., Wilsbacher, J. L., Miranti, C. K., Brugge, J. S., Shattil, S. J. and Ginsberg, M. H. (2001). Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr. Biol.11, 1799-1804.
Wozniak, M. A., Desai, R., Solski, P. A., Der, C. J. and Keely, P. J. (2003). ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J. Cell Biol.163, 583-595.
Yamada, K. M. and Even-Ram, S. (2002). Integrin regulation of growth factor receptors. Nat. Cell Biol.4, E75-E76.
Yamaguchi, H., Pixley, F. and Condeelis, J. (2006). Invadopodia and podosomes in tumor invasion. Eur. J. Cell Biol.85, 213-218.
Yamana, N., Arakawa, Y., Nishino, T., Kurokawa, K., Tanji, M., Itoh, R. E., Monypenny, J., Ishizaki, T., Bito, H., Nozaki, K. et al. (2006). The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol. Cell. Biol.26, 6844-6858.