Immunology and Cell Biology
SCIE-ISI SCOPUS (1987-2025)
1440-1711
0818-9641
Mỹ
Cơ quản chủ quản: WILEY , John Wiley & Sons Inc.
Lĩnh vực:
Cell BiologyImmunologyImmunology and Allergy
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Các bài báo tiêu biểu
Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements
Tập 76 Số 1 - Trang 34-40 - 1998
We describe the generation of ovalbumin (OVA)‐specific, MHC class II‐restricted
αβ T cell receptor (TCR) transgenic mice. Initial attempts at generating these
transgenic mice utilized heterologous regulatory elements to drive the
expression of cDNA genes encoding the separate α‐ and β‐chains of the TCR.
Unexpectedly, T cells bearing the transgenic αβ TCR failed to emerge from the
thymus in these m...
A NEW ANALYSIS OF ALLOGENEIC INTERACTIONS
Tập 53 Số 1 - Trang 27-42 - 1975
SummaryAllogeneic reactions have conventionally been considered as typical
immune responses by one population of cells to antigens present on the other.
This view is inadequate, since it does not explain many features of these
reactions, among which are: (1) reactivity is much higher between different
strains within a species than between species, in spite of the much greater
antigenic disparity i...
The structure and function of hyaluronan: An overview
Tập 74 Số 2 - 1996
SummaryHyaluronan is a major component of synovial tissue and fluid as well as
other soft connective tissues. It is a high‐Mr polysaccharide which forms
entangled networks already at dilute concentrations (< 1 mg/mL) and endows its
solutions with unique rheological properties. Physiological functions of
hyaluronan (lubrication, water homeostasis. macromolecular filtering, exclusion,
etc.) have bee...
Fluorescent dyes for lymphocyte migration and proliferation studies
Tập 77 Số 6 - Trang 499-508 - 1999
Fluorescent dyes are increasingly being exploited to track lymphocyte migration
and proliferation. The present paper reviews the properties and performance of
some 14 different fluorescent dyes that have been used during the last 20 years
to monitor lymphocyte migration. Of the 14 dyes discussed, two stand out as
being the most versatile in terms of long‐term tracking of lymphocytes and their
abil...
Cross‐talk between pro‐inflammatory transcription factors and glucocorticoids
Tập 79 Số 4 - Trang 376-384 - 2001
Asthma is a chronic inflammatory disease of the airway that is characterized by
cellular infiltration and activation. These processes are induced by
overexpression of chemokines and cytokines, such as eotaxin, IL‐1β and GM‐CSF.
These mediators are downstream targets for the transcription factors activator
protein‐1 (AP‐1) and nuclear factor‐κB (NF‐κB), which control the expression of
most immunomo...
Phương pháp phản ứng chuỗi polymerase (RT–PCR) trong thời gian thực để đo lường biểu hiện mRNA của cytokine và yếu tố tăng trưởng bằng cách sử dụng các mồi huỳnh quang hoặc SYBR Green I Dịch bởi AI
Tập 79 Số 3 - Trang 213-221 - 2001
Phản ứng chuỗi polymerase (RT–PCR) trong thời gian thực là phương pháp được lựa
chọn để đo lường nhanh chóng và tái sản xuất được nồng độ biểu hiện của cytokine
hoặc yếu tố tăng trưởng trong các mẫu nhỏ. Các phương pháp phát hiện huỳnh quang
để theo dõi PCR trong thời gian thực bao gồm các mồi huỳnh quang được gán nhãn
với thuốc nhuộm báo cáo và thuốc nhuộm quenching, chẳng hạn như các mồi Taqman
...
#RT–PCR #cytokine #yếu tố tăng trưởng #mồi huỳnh quang #SYBR Green I
Cell death induced by the Fas/Fas ligand pathway and its role in pathology
Tập 77 Số 4 - Trang 312-317 - 1999
Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results
in apoptotic cell death, mediated by caspase activation. Cell death mediated via
Fas/FasL interaction is important for homeostasis of cells in the immune system
and for maintaining immune‐privileged sites in the body. Killing via the
Fas/FasL pathway also constitutes an important pathway of killing for cytotoxic
T cells...
Balancing immunity and pathology in visceral leishmaniasis
Tập 85 Số 2 - Trang 138-147 - 2007
Experimental visceral leishmaniasis (VL) caused by infection with Leishmania
donovani results in the development of organ‐specific immunity in the two main
target tissues of infection, the spleen and the liver. The liver is the site of
an acute resolving infection associated with the development of inflammatory
granulomas around infected Kupffer cells, and resistance to reinfection.
Paradoxically,...
Regulation of the inflammatory response in asthma by mast cell products
Tập 79 Số 2 - Trang 149-153 - 2001
In airways, mast cells lie adjacent to nerves, blood vessels and lymphatics,
which highlights their pivotal importance in regulating allergic inflammatory
processes. In asthma, mast cells are predominantly activated by IgE receptor
cross linking. In response to activation, preformed mediators that are stored
bound to proteoglycans, for example, TNF‐α, IL‐4, IL‐13, histamine, tryptase and
chymase, ...
Structure, function and regulation of the Toll/IL‐1 receptor adaptor proteins
Tập 85 Số 6 - Trang 411-419 - 2007
The Toll/IL‐1 receptor (TIR) domain plays a central role in Toll‐like receptor
(TLR) signalling. All TLRs contain a cytoplasmic TIR domain, which, upon
activation, acts as a scaffold to recruit adaptor proteins. The adaptor proteins
MyD88, Mal, TRIF, TRAM and SARM are also characterized by the presence of a TIR
domain. MyD88, Mal, TRIF and TRAM associate with the TLRs via homophilic TIR
domain int...