The structure and function of hyaluronan: An overview

Immunology and Cell Biology - Tập 74 Số 2 - 1996
Torvard C. Laurent1, Ulla B.G. Laurent, J R Fraser
1Department of Medical and Physiological Chemistry, University of Uppsala, Sweden.

Tóm tắt

Summary

Hyaluronan is a major component of synovial tissue and fluid as well as other soft connective tissues. It is a high‐Mr polysaccharide which forms entangled networks already at dilute concentrations (< 1 mg/mL) and endows its solutions with unique rheological properties. Physiological functions of hyaluronan (lubrication, water homeostasis. macromolecular filtering, exclusion, etc.) have been ascribed to the properties of these networks. Recently a number of specific interactions between hyaluronan and a group of proteins named hyaladherins have also pointed towards a role of hyaluronan in recognition and the regulation of cellular activities. Many more or less well documented hypotheses have been proposed for the function of hyaluronan in joints, for example, that it should lubricate, protect cartilage surfaces, scavenge free radicals and debris, keep the joint cavities open, form flow barriers in the synovium and prevent capillary growth.

Từ khóa


Tài liệu tham khảo

10.1096/fasebj.6.7.1563592

Evered D, 1989, The Biology of Hyaluronan. Ciba Foundation Symposium 143

10.1002/art.1780100407

10.1136/ard.44.12.817

Rydell NW, 1970, Hyaluronic acid in synovial fluid. VI. Effect of intra‐articular injection of hyaluronic acid on the clinical symptoms of arthritis in track horses, Acta Vet. Scand., 11, 139

10.1152/physrev.1978.58.1.255

10.1016/0006-3002(60)90826-X

10.1016/0022-2836(80)90294-6

Scott JE, 1991, Secondary and tertiary structures of hyaluronan in aqueous solution, investigated by rotary shadowing‐electron microscopy and computer simulation, Biochem. J., 274, 600, 10.1042/bj2740699

10.1002/bip.1968.360060603

10.3109/00016488709102834

10.1007/BF00318761

10.1038/166785b0

10.1016/0304-4165(72)90160-2

Hardingham TE, 1992, Articular Cartilage and Osteoarthrilis., 5

10.1016/0076-6879(94)45008-0

10.1002/j.1460-2075.1992.tb05527.x

10.1083/jcb.116.2.545

10.4049/jimmunol.151.11.6593

Huang L, 1993, A serum‐derived hyaluronan‐associated protein (SHAP) is the heavy chain of the inter‐α‐trypsin inhibitor, J. Biol. Chem., 268, 725

Chen L, 1992, Identification of a factor in fetal bovine serum that stabilizes the cumulus extracellular matrix, J. Biol. Chem., 267, 380

10.1074/jbc.270.17.9698

Sandson J, 1965, Altered properties of pathological hyaluronate due to a bound inter‐alpha trypsin inhibitor, Trans. Assoc. Am. Physicians, 78, 304

10.1126/science.175.4024.898

Underhill CB, 1985, Characterization and identification of the hyaluronate binding site from membranes of SV‐3T3 cells, J. Biol. Chem., 260, 8128, 10.1016/S0021-9258(17)39573-X

10.1016/S0065-2776(08)60537-4

10.1016/0955-0674(94)90100-7

10.1083/jcb.117.6.1343

10.1083/jcb.112.5.1041

10.1042/bj2000415

10.1042/bj2230617

McCourt PAG, 1994, Intercellular adhesion molecule‐1 is a cell surface receptor for hyaluronan, J. Biol. Chem., 2698, 081

Gustafson S., 1996, Hyaluronan receptors on liver endothelial cells, Trends Glycosci. Glycotechnol., 8, 1, 10.4052/tigg.8.13

10.1016/0014-4827(68)90530-2

10.1096/fasebj.7.13.7691670

Heldin P, 1993, Synthesis and assembly of the hyaluronan‐containing coats around normal and mesothelial cells, Exp Cell Biol., 208, 422

10.1113/expphysiol.1991.sp003474

10.1016/S0049-0172(10)80015-0

McDonald JN, 1995, Effect of intra‐articular hyaluronan on pressure‐flow relation across synovium in anaesthetized rabbits, J. Physiol., 485, 179, 10.1113/jphysiol.1995.sp020722

Edwards JCW, 1994, The formation of human synovial cavities: a possible role for hyaluronan and CD44 in altered interzone cohesion, J. Anat., 185, 355

10.1113/jphysiol.1953.sp004842

10.1038/228377a0

10.1016/0021-9290(93)90062-J

10.1136/ard.31.6.513

10.1136/ard.47.5.377

10.1016/0304-4165(87)90109-7

10.1136/ard.54.5.429

10.1016/0049-0172(92)90047-H

10.1136/ard.54.5.389

Adams ME., 1993, Viscosupplementation: A treatment for osteoarthritis, J. Rheumatol., 20, 1

Thông tin
Thông tin xuất bản

Immunology and Cell Biology

Tập 74 Số 2

Thông tin tác giả