Cell death induced by the Fas/Fas ligand pathway and its role in pathology
Tóm tắt
Engagement of the cell death surface receptor Fas by Fas ligand (FasL) results in apoptotic cell death, mediated by caspase activation. Cell death mediated via Fas/FasL interaction is important for homeostasis of cells in the immune system and for maintaining immune‐privileged sites in the body. Killing via the Fas/FasL pathway also constitutes an important pathway of killing for cytotoxic T cells. Fas ligand is induced in activated T cells, resulting in activation‐induced cell death by the Fas/FasL pathway. Recently it has been shown that the Fas receptor can also be up‐regulated following a lesion to the cell, particularly that induced by DNA‐damaging agents. This can then result in killing of the cell by a Fas/FasL‐dependent pathway. Up‐regulation of Fas receptor following DNA damage appears to be p53 dependent.
Từ khóa
Tài liệu tham khảo
Schulzeosthoff K, 1998, Apoptosis signalling by death receptors., Eur. J. Biochem., 254, 439, 10.1046/j.1432-1327.1998.2540439.x
Watanabe‐Fukunaga R, 1992, The cDNA structure, expression and chromosomal assignment of the mouse Fas antigen., J. Immunol., 148, 1274, 10.4049/jimmunol.148.4.1274
Krammer PH, 1998, The CD95 (APO‐1/Fas) CD95L system., Toxicol. Lett., 103, 131, 10.1016/S0378-4274(98)00297-5
Osborne BA, 1998, When Cells Die: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death, 245
Turner PC, 1994, Virorecepters, Virokines and Related Immune Modulators Encoded by DNA Viruses, 67
Hu S, 1997, I‐FLICE, a novel inhibitor of tumor necrosis factor receptor and CD95 induced apoptosis., J. Biol. Chem., 272, 17 255, 10.1074/jbc.272.28.17255
Tewari M, 1995, CrmA, a poxvirus‐encoded serpin, inhibits cytotoxic T‐lymphocyte‐ mediated apoptosis., J. Biol. Chem., 270, 22 705, 10.1074/jbc.270.39.22705
Müllbacher A, 1999, Poxvirus encoded serpins do not prevent cytolytic T cell mediated recovery from primary infections., J. Immunol., 162, 10.4049/jimmunol.162.12.7315
Krammer PH, 1997, The tumor strikes back – new data on the expression of the CD95 (Apo‐1/Fas) receptor/ligand system may cause paradigm changes in our view on drug treatment and tumor immunology., Cell Death Differ., 4, 363, 10.1038/sj.cdd.4400252
Shi LF, 1997, Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB localization., J. Exp. Med., 185, 885
Takahara T, 1998, Delayed Fas mediated hepatocyte apoptosis during liver regeneration in mice – hepatoprotective role of TNF‐alpha., Hepatology, 27, 1643, 10.1002/hep.510270625
Tsutsui H, 1997, IL‐18 accounts for both TNF‐alpha and Fas ligand mediated hepatotoxicity pathways in endotoxin‐induced liver injury in mice., J. Immunol., 159, 3961, 10.4049/jimmunol.159.8.3961
Nishimuramorita Y, 1997, Amelioration of systemic autoimmune disease by the stimulation of apoptosis promoting receptor Fas with anti‐fas mab., Int. Immunol., 9, 1793, 10.1093/intimm/9.12.1793
Akasaka Y, 1998, Induction of Fas mediated apoptosis in a human renal epithelial cell line by interferon‐gamma – involvement of fas‐mediated apoptosis in acute renal rejection., Mod. Pathol., 11, 1107
Beurton F, 1999, Transcriptional activation of CYP2C, MxA and Fas in sudden infant death syndrome., Int. J. Mol. Med., 3, 33
Saito I, 1999, Fas ligand‐mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL‐10., J. Immunol., 162, 2488, 10.4049/jimmunol.162.5.2488
Seidel R, 1999, Apoptosis‐associated proteins p53 and APO‐1/Fas (CD95) in brains of adult patients with Down Syndrome., Neurosci. Lett., 260, 9, 10.1016/S0304-3940(98)00945-8
Fulda S, 1997, The CD95 (APO‐1/Fas) system mediates drug induced apoptosis in neuroblastoma cells., Cancer Res., 57, 3823
Nakamura S, 1997, Induction of apoptosis in HL60 leukemic cells by anti‐cancer drugs in combination with anti‐fas monoclonal antibody., Anticancer Res., 17, 173