Immunology and Cell Biology

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Endogenous, or therapeutically induced, type I interferon responses differentially modulate Th1/Th17‐mediated autoimmunity in the CNS
Immunology and Cell Biology - Tập 90 Số 5 - Trang 505-509 - 2012
Ulrich Kalinke, Marco Prinz
Different viruses trigger pattern recognition receptor systems, such as Toll‐like receptors or cytosolic RIG‐I like helicases (RLH), and thus induce early type I interferon (IFN‐I) responses. Such responses may confer protection until adaptive immunity is activated to an extent that the pathogen can be eradicated. Interestingly, the same innate immune mechanisms that are relevant for early...... hiện toàn bộ
A CD2 high‐expressing stress‐resistant human plasmacytoid dendritic‐cell subset
Immunology and Cell Biology - Tập 94 Số 5 - Trang 447-457 - 2016
Christian Bryant, Phillip D. Fromm, Fiona Kupresanin, Georgina J. Clark, Kenneth Lee, Candice Clarke, Pablo A. Silveira, Hayley Suen, Ross Brown, Elizabeth Newman, Ilona Cunningham, P. Joy Ho, John Gibson, Kenneth F. Bradstock, Douglas Joshua, Derek N.J. Hart
Human plasmacytoid dendritic cells (pDCs) were considered to be a phenotypically and functionally homogeneous cell population; however, recent analyses indicate potential heterogeneity. This is of major interest, given their importance in the induction of anti‐viral responses and their role in creating immunologically permissive environments for human malignancies. For this reason, we inve...... hiện toàn bộ
Toward a functional characterization of blood monocytes
Immunology and Cell Biology - Tập 89 Số 1 - Trang 2-4 - 2011
Prakash Saha, Frédéric Geissmann
STUDIES ON THE BLOOD COPPER OF SHEEP AND OF COWS
Immunology and Cell Biology - Tập 19 Số 4 - Trang 249-254 - 1941
AB Beck
Novel adjuvant based on a proteoliposome‐derived cochleate structure containing native lipopolysaccharide as a pathogen‐associated molecular pattern
Immunology and Cell Biology - Tập 82 Số 6 - Trang 603-610 - 2004
Oliver Pérez, Gustavo Bracho, Miriam Lastre, Néstor Mora, Judith del Campo, Danay Gil, Caridad Zayas, Reinaldo Acevedo, Domingo González, J. Alejandro López, Carlos Taboada, Rosa L. Solís
Proteoliposomes (PL) from Neisseria meningitidis B have been widely used as a core antigen for antimeningococcal vaccination. PL contain major outer membrane proteins, LPS and phospholipids, and they induce a strong Th1 immune response, but they have low stability in solution. Attending to the need for new vaccine adjuvants, we developed a highly stable cochleate...... hiện toàn bộ
TB vaccines: current status and future perspectives
Immunology and Cell Biology - Tập 87 Số 4 - Trang 279-286 - 2009
Claus Aagaard, Jes Dietrich, Mark Doherty, Peter Andersen
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T‐cell recognition in PPD‐positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put to...... hiện toàn bộ
Regulating B‐cell activation and survival in response to TLR signals
Immunology and Cell Biology - Tập 85 Số 6 - Trang 471-475 - 2007
Steve Gerondakis, Raelene J. Grumont, Ashish Banerjee
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B‐cell receptor in a specific antigen‐defined manner, or through Toll‐like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nucle...... hiện toàn bộ
Immunobiology of Toll‐like receptors: Emerging trends
Immunology and Cell Biology - Tập 84 Số 4 - Trang 333-341 - 2006
Sachchida Nand Pandey, Devendra K. Agrawal
Toll‐like receptors (TLR), a family of evolutionarily conserved pathogen recognition receptors, play pivotal role as primary sensors of invading pathogens. TLR identify molecular motifs of infectious agents (pathogen associated molecular patterns) and elicit an effective defensive response against them. Mammalian TLR derive their name from the Drosophila Toll pro...... hiện toàn bộ
Phương pháp phản ứng chuỗi polymerase (RT–PCR) trong thời gian thực để đo lường biểu hiện mRNA của cytokine và yếu tố tăng trưởng bằng cách sử dụng các mồi huỳnh quang hoặc SYBR Green I Dịch bởi AI
Immunology and Cell Biology - Tập 79 Số 3 - Trang 213-221 - 2001
Jian Yin, Nicholas Shackel, Amany Zekry, Peter H. McGuinness, Craig Richards, Karien Van Der Putten, Geoffrey W. McCaughan, Josette Eris, G. Alex Bishop
Phản ứng chuỗi polymerase (RT–PCR) trong thời gian thực là phương pháp được lựa chọn để đo lường nhanh chóng và tái sản xuất được nồng độ biểu hiện của cytokine hoặc yếu tố tăng trưởng trong các mẫu nhỏ. Các phương pháp phát hiện huỳnh quang để theo dõi PCR trong thời gian thực bao gồm các mồi huỳnh quang được gán nhãn với thuốc nhuộm báo cáo và thuốc nhuộm quenching, chẳng hạn như các mồi...... hiện toàn bộ
#RT–PCR #cytokine #yếu tố tăng trưởng #mồi huỳnh quang #SYBR Green I
PLASMA CLEARANCE AND DISTRIBUTION OF 125I‐OVINE PLACENTAL LACTOGEN IN SHEEP
Immunology and Cell Biology - Tập 61 Số 3 - Trang 301-311 - 1983
Surendranath Veeram Reddy, Watkins Wb
SummaryThe plasma clearance of 125I‐ovine placental lactogen (125I‐oPL) in pregnant, non‐pregnant and foetal sheep followed a biphasic exponential curve. The initial half‐life (t1(½)) of the hormone ranged from 5·7–12·7 min. The molecular identity of 125I‐oPL in plasma samples was e...... hiện toàn bộ
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