Immunology and Cell Biology

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Novel adjuvant based on a proteoliposome‐derived cochleate structure containing native lipopolysaccharide as a pathogen‐associated molecular pattern
Immunology and Cell Biology - Tập 82 Số 6 - Trang 603-610 - 2004
Oliver Pérez, Gustavo Bracho, Miriam Lastre, Néstor Mora, Judith del Campo, Danay Gil, Caridad Zayas, Reinaldo Acevedo, Domingo González, J. Alejandro López, Carlos Taboada, Rosa L. Solís
Proteoliposomes (PL) from Neisseria meningitidis B have been widely used as a core antigen for antimeningococcal vaccination. PL contain major outer membrane proteins, LPS and phospholipids, and they induce a strong Th1 immune response, but they have low stability in solution. Attending to the need for new vaccine adjuvants, we developed a highly stable cochleate structure (CS) from PL using a tec... hiện toàn bộ
TB vaccines: current status and future perspectives
Immunology and Cell Biology - Tập 87 Số 4 - Trang 279-286 - 2009
Claus Aagaard, Jes Dietrich, Mark Doherty, Peter Andersen
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T‐cell recognition in PPD‐positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put together in fusion molecules. Three s... hiện toàn bộ
Activation‐induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack
Immunology and Cell Biology - Tập 80 Số 2 - Trang 131-137 - 2002
Stephen G. Maher, Deirdre Toomey, Claire Condron, David Bouchier‐Hayes
Activation‐induced cell death (AICD) is the process by which cells undergo apoptosis in a controlled manner through the interaction of a death factor and its receptor. Programmed cell death can be induced by a number of physiological and pathological factors including Fas (CD95)–Fas ligand (FasL/CD95L) interaction, tumour necrosis factor (TNF), ceramide, and reactive oxygen species (ROS). Fas is a... hiện toàn bộ
Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger
Immunology and Cell Biology - Tập 90 Số 7 - Trang 668-675 - 2012
Charlotte E. Egan, Sara Cohen, Eric Denkers
Oral infection of certain inbred mouse strains with the protozoan Toxoplasma gondii triggers inflammatory pathology resembling lesions seen during human inflammatory bowel disease, in particular Crohn's disease (CD). Damage triggered by the parasite is largely localized to the distal portion of the small intestine, and as such is one of only a few models for ileal inflammation. This is important b... hiện toàn bộ
THE EFFECT OF PHENYLEPHRINE ON EXCRETION OF FLUID AND ELECTROLYTES BY THE PAROTID AND MANDIBULAR GLANDS OF THE RAT
Immunology and Cell Biology - Tập 57 Số 5 - Trang 555-562 - 1979
JA Young, DI Cook, G.R.D. Jones, Joe McGirr, Campbell H. Thompson
SummaryThe effect has been investigated of the α‐adrenergic agonist, phenylephrine, on excretion of water and electrolytes (Na, K, and HCO3) by the parotid and mandibular glands of the rat. In the mandibular glands the agonist was as effective as acetylcholine (or parasympathetic nerve stimulation) in stimulating secretion, and the electrolyte excretory patterns seen in the two modes of stimulatio... hiện toàn bộ
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Immunology and Cell Biology - Tập 87 Số 8 - Trang 601-605 - 2009
Norbert F. Voelkel, Sarah Spiegel
A hypothesis is presented that asthma is not only an airway disease, but that the disease involves the entire lung, and that the chronicity of asthma and asthma exacerbations can perhaps be explained if one considers asthma as a systemic disease. Increased lung—not only airway—vascularity may be the result of the action of angiogenesis factors, such as vascular endothelial growth factor (VEGF) and... hiện toàn bộ
THE SUSCEPTIBILITY OF MICE TO NORTH QUEENSLAND STRAINS OF LEPTOSPIRAE
Immunology and Cell Biology - Tập 37 Số 1 - Trang 17-30 - 1959
Marie L. Emanuel
T‐cell migration: Kruppeled T cells move again
Immunology and Cell Biology - Tập 86 Số 4 - Trang 297-298 - 2008
Kristin A. Hogquist, Michael Weinreich, Stephen C. Jameson
Differences in antigen‐binding affinity caused by single amino acid substitution in the variable region of the heavy chain
Immunology and Cell Biology - Tập 71 Số 4 - Trang 239-247 - 1993
Jim Xiang, Zhi‐Nan Chen, Louis T. J. Delbaere, Enwu Liu
SummarySite‐directed mutagenesis has been used to examine the importance of histidine‐99 in the VH CDR3 region of a mouse/human chimeric anti‐TAG72 antibody, cB72.3‐1‐3. The expression vectors mpSV2neo‐EPl‐Vm4–10C.γ1, containing seven different mutant VH region fragments (Vm4–10) in association with the immunoglobulin enhancer (E), promoter (P1) and human genomic Cγ1 region fragments, were transfe... hiện toàn bộ
STUDIES ON CYTOPHILIC ANTIBODIES
Immunology and Cell Biology - Tập 46 Số 1 - Trang 51-61 - 1968
Steven Kossard, D. S. Nelson
SummaryAn attempt was made to study the. dynamics of the interaction between cytophilie antibodies and the macrophage surface. Two aspects of the problem received particular attention: (1) the ability of macrophage cytophilic antibodies to sensitize (confer an affinity for antigen upon) cells of different species, and (2) the inhibitory effect of normal sera on homologous and heterologons sensitiz... hiện toàn bộ
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