Immunology and Cell Biology

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Cross‐talk between pro‐inflammatory transcription factors and glucocorticoids
Immunology and Cell Biology - Tập 79 Số 4 - Trang 376-384 - 2001
Ian M. Adcock, Gaetano Caramori
Asthma is a chronic inflammatory disease of the airway that is characterized by cellular infiltration and activation. These processes are induced by overexpression of chemokines and cytokines, such as eotaxin, IL‐1β and GM‐CSF. These mediators are downstream targets for the transcription factors activator protein‐1 (AP‐1) and nuclear factor‐κB (NF‐κB), which control the expression of most ...... hiện toàn bộ
Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice
Immunology and Cell Biology - Tập 89 Số 1 - Trang 130-142 - 2011
Guangwei Liu, Haixia Ma, Lin Qiu, Long Li, Yuhong Cao, Jun Ma, Yong Zhao
CD4+CD25+ regulatory T cells (Treg cells) are important in maintenance of peripheral tolerance. The direct effect of CD4+CD25+ Treg cells on macrophages was studied using a mouse model in which syngeneic CD4+CD25+ Treg cells were adoptively transferred into the peri...... hiện toàn bộ
A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry
Immunology and Cell Biology - Tập 71 Số 6 - Trang 549-557 - 1993
Xu Xiaoning, Ian Beckman, Michael Ahern, John Bradley
SummaryThis study used a panel of mAb and multiparameter flow cytometry to assess the composition of PBL from healthy aged individuals. The results showed that while total lymphocyte numbers altered only marginally in the aged (≥ 70 years) there were significant changes in the distribution of various sub‐populations; for example, there were lower numbers of CD3... hiện toàn bộ
Induction of type I IFNs by intracellular DNA‐sensing pathways
Immunology and Cell Biology - Tập 90 Số 5 - Trang 474-482 - 2012
Taner Cavlar, Andrea Ablasser, Veit Hornung
A successful antimicrobial immune response involves the coordinate action of cells and soluble factors, with the cytokine family of type I interferons (IFNs) having a central role. Type I IFNs are not only crucial in conferring immediate antimicrobial, most importantly antiviral effects, but they also have an essential role in bridging the innate with the adaptive immune response. Therefor...... hiện toàn bộ
Novel adjuvant based on a proteoliposome‐derived cochleate structure containing native lipopolysaccharide as a pathogen‐associated molecular pattern
Immunology and Cell Biology - Tập 82 Số 6 - Trang 603-610 - 2004
Oliver Pérez, Gustavo Bracho, Miriam Lastre, Néstor Mora, Judith del Campo, Danay Gil, Caridad Zayas, Reinaldo Acevedo, Domingo González, J. Alejandro López, Carlos Taboada, Rosa L. Solís
Proteoliposomes (PL) from Neisseria meningitidis B have been widely used as a core antigen for antimeningococcal vaccination. PL contain major outer membrane proteins, LPS and phospholipids, and they induce a strong Th1 immune response, but they have low stability in solution. Attending to the need for new vaccine adjuvants, we developed a highly stable cochleate...... hiện toàn bộ
TB vaccines: current status and future perspectives
Immunology and Cell Biology - Tập 87 Số 4 - Trang 279-286 - 2009
Claus Aagaard, Jes Dietrich, Mark Doherty, Peter Andersen
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T‐cell recognition in PPD‐positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put to...... hiện toàn bộ
Activation‐induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack
Immunology and Cell Biology - Tập 80 Số 2 - Trang 131-137 - 2002
Stephen G. Maher, Deirdre Toomey, Claire Condron, David Bouchier‐Hayes
Activation‐induced cell death (AICD) is the process by which cells undergo apoptosis in a controlled manner through the interaction of a death factor and its receptor. Programmed cell death can be induced by a number of physiological and pathological factors including Fas (CD95)–Fas ligand (FasL/CD95L) interaction, tumour necrosis factor (TNF), ceramide, and reactive oxygen species (ROS). ...... hiện toàn bộ
Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger
Immunology and Cell Biology - Tập 90 Số 7 - Trang 668-675 - 2012
Charlotte E. Egan, Sara Cohen, Eric Denkers
Oral infection of certain inbred mouse strains with the protozoan Toxoplasma gondii triggers inflammatory pathology resembling lesions seen during human inflammatory bowel disease, in particular Crohn's disease (CD). Damage triggered by the parasite is largely localized to the distal portion of the small intestine, and as such is one of only a few models for ilea...... hiện toàn bộ
THE EFFECT OF PHENYLEPHRINE ON EXCRETION OF FLUID AND ELECTROLYTES BY THE PAROTID AND MANDIBULAR GLANDS OF THE RAT
Immunology and Cell Biology - Tập 57 Số 5 - Trang 555-562 - 1979
JA Young, DI Cook, G.R.D. Jones, Joe McGirr, Campbell H. Thompson
SummaryThe effect has been investigated of the α‐adrenergic agonist, phenylephrine, on excretion of water and electrolytes (Na, K, and HCO3) by the parotid and mandibular glands of the rat. In the mandibular glands the agonist was as effective as acetylcholine (or parasympathetic nerve stimulation) in stimulating secretion, and the electrolyte ...... hiện toàn bộ
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Immunology and Cell Biology - Tập 87 Số 8 - Trang 601-605 - 2009
Norbert F. Voelkel, Sarah Spiegel
A hypothesis is presented that asthma is not only an airway disease, but that the disease involves the entire lung, and that the chronicity of asthma and asthma exacerbations can perhaps be explained if one considers asthma as a systemic disease. Increased lung—not only airway—vascularity may be the result of the action of angiogenesis factors, such as vascular endothelial growth factor (V...... hiện toàn bộ
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