Immunology and Cell Biology

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TB vaccines: current status and future perspectives
Immunology and Cell Biology - Tập 87 Số 4 - Trang 279-286 - 2009
Claus Aagaard, Jes Dietrich, Mark Doherty, Peter Andersen
Vaccines against intracellular pathogens such as Mycobacterium tuberculosis need to induce strong cellular immune responses. Antigen discovery programs have exploited this and used proteome studies and T‐cell recognition in PPD‐positive individuals to select proteins and after testing for protective efficacy in animals the most promising proteins have been put to...... hiện toàn bộ
Novel adjuvant based on a proteoliposome‐derived cochleate structure containing native lipopolysaccharide as a pathogen‐associated molecular pattern
Immunology and Cell Biology - Tập 82 Số 6 - Trang 603-610 - 2004
Oliver Pérez, Gustavo Bracho, Miriam Lastre, Néstor Mora, Judith del Campo, Danay Gil, Caridad Zayas, Reinaldo Acevedo, Domingo González, J. Alejandro López, Carlos Taboada, Rosa L. Solís
Proteoliposomes (PL) from Neisseria meningitidis B have been widely used as a core antigen for antimeningococcal vaccination. PL contain major outer membrane proteins, LPS and phospholipids, and they induce a strong Th1 immune response, but they have low stability in solution. Attending to the need for new vaccine adjuvants, we developed a highly stable cochleate...... hiện toàn bộ
Why is effective treatment of asthma so difficult? An integrated systems biology hypothesis of asthma
Immunology and Cell Biology - Tập 87 Số 8 - Trang 601-605 - 2009
Norbert F. Voelkel, Sarah Spiegel
A hypothesis is presented that asthma is not only an airway disease, but that the disease involves the entire lung, and that the chronicity of asthma and asthma exacerbations can perhaps be explained if one considers asthma as a systemic disease. Increased lung—not only airway—vascularity may be the result of the action of angiogenesis factors, such as vascular endothelial growth factor (V...... hiện toàn bộ
THE SUSCEPTIBILITY OF MICE TO NORTH QUEENSLAND STRAINS OF LEPTOSPIRAE
Immunology and Cell Biology - Tập 37 Số 1 - Trang 17-30 - 1959
Marie L. Emanuel
T‐cell migration: Kruppeled T cells move again
Immunology and Cell Biology - Tập 86 Số 4 - Trang 297-298 - 2008
Kristin A. Hogquist, Michael Weinreich, Stephen C. Jameson
Differences in antigen‐binding affinity caused by single amino acid substitution in the variable region of the heavy chain
Immunology and Cell Biology - Tập 71 Số 4 - Trang 239-247 - 1993
Jim Xiang, Zhi‐Nan Chen, Louis T. J. Delbaere, Enwu Liu
SummarySite‐directed mutagenesis has been used to examine the importance of histidine‐99 in the VH CDR3 region of a mouse/human chimeric anti‐TAG72 antibody, cB72.3‐1‐3. The expression vectors mpSV2neo‐EPl‐Vm4–10C.γ1, containing seven different mutant VH region fragments (V... hiện toàn bộ
STUDIES ON CYTOPHILIC ANTIBODIES
Immunology and Cell Biology - Tập 46 Số 1 - Trang 51-61 - 1968
Steven Kossard, D. S. Nelson
SummaryAn attempt was made to study the. dynamics of the interaction between cytophilie antibodies and the macrophage surface. Two aspects of the problem received particular attention: (1) the ability of macrophage cytophilic antibodies to sensitize (confer an affinity for antigen upon) cells of different species, and (2) the inhibitory effect of normal sera on hom...... hiện toàn bộ
Linking the T cell receptor to the single cell transcriptome in antigen‐specific human T cells
Immunology and Cell Biology - Tập 94 Số 6 - Trang 604-611 - 2016
Auda A. Eltahla, Simone Rizzetto, Mehdi R. Pirozyan, Brigid Betz‐Stablein, Vanessa Venturi, Katherine Kedzierska, Andrew R. Lloyd, Rowena A. Bull, Fabio Luciani
Heterogeneity of T cells is a hallmark of a successful adaptive immune response, harnessing the vast diversity of antigen‐specific T cells into a coordinated evolution of effector and memory outcomes. The T cell receptor (TCR) repertoire is highly diverse to account for the highly heterogeneous antigenic world. During the response to a virus multiple individual clones of antigen specific C...... hiện toàn bộ
Regulating B‐cell activation and survival in response to TLR signals
Immunology and Cell Biology - Tập 85 Số 6 - Trang 471-475 - 2007
Steve Gerondakis, Raelene J. Grumont, Ashish Banerjee
Following encounters with microbes, cellular activation programs that involve the control of proliferation and survival are initiated in follicular B cells either via the B‐cell receptor in a specific antigen‐defined manner, or through Toll‐like receptors (TLRs) that recognize specific microbial products. This review summarizes and discusses recent findings that shed light on how the nucle...... hiện toàn bộ
IL‐1β transcript stability in monocytes is linked to cytoskeletal reorganization and the availability of mRNA degradation factors
Immunology and Cell Biology - Tập 80 Số 4 - Trang 328-339 - 2002
Oksana I. Sirenko, Ulrich Böcker, J. Steven Morris, J. S. Haskill, Janet Watson
Monocyte extravasation initiates reorganization of the cytoskeleton (CSK) and adhesion‐dependent cytokine gene transcription. The actin CSK is thought to be crucial for compartmentalization and translation of mRNA, many of which contain AU‐rich (ARE) instability motifs in the 3′ untranslated region. We investigated regulation of adhesion‐induced IL‐1β expression by the monocyte CSK. In ser...... hiện toàn bộ
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