IUBMB Life
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Platelet Interactions in ThrombosisAbstract Patho/physiological platelet aggregate (thrombus) formation is initiated by engagement of platelet surface receptors, glycoprotein (GP)Ib‐IX‐V and GPVI that bind von Willebrand factor or collagen. Although beneficial in response to vascular injury by preventing blood loss (haemostasis), platelet aggregation in a sclerotic coronary artery or other diseased b... ... hiện toàn bộ
IUBMB Life - Tập 56 Số 1 - Trang 13-18 - 2004
The Mitochondrial Potassium CycleAbstract The mitochondrial K + cycle consists of influx and efflux pathways for K + and anions. Net movement of K + salts across the inner membrane causes changes of matrix volume, so regulation of the cycle is vital for maintaining the structural integrity of the organelle. The mitochondrial K + cycle also appears to play important roles in cellular pathophysiology... ... hiện toàn bộ
IUBMB Life - Tập 52 Số 3-5 - Trang 153-158 - 2001
Sphingosine 1‐Phosphate Activates Erk‐1/‐2 by Transactivating Epidermal Growth Factor Receptor in Rat‐2 CellsAbstract We investigated a signaling pathway leading to activation of extracellular signal‐regulated protein kinase (Erk) 1 and 2 in Rat‐2 cells stimulated with sphingosine 1‐phosphate (S1P). S1P treatment transiently activated Erk‐1/‐2 in a dose‐dependent manner, and its activation was blocked by pertussis toxin, expression of RasN17, or inhibition of Raf or MEK‐1/... ... hiện toàn bộ
IUBMB Life - Tập 50 Số 2 - Trang 119-124 - 2000
Fluorescent proteins for live cell imaging: Opportunities, limitations, and challengesAbstract The green fluorescent protein (GFP) from the jellyfish Aequorea victoria can be used as a genetically encoded fluorescence marker due to its autocatalytic formation of the chromophore. In recent years, numerous GFP‐like proteins with emission colors ranging from cyan to red were discovered in marine organisms. Their diverse molecu... ... hiện toàn bộ
IUBMB Life - Tập 61 Số 11 - Trang 1029-1042 - 2009
Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic CellsAbstract Geldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells. DNA flow‐cytometric analysis indicated that GA‐induced growth arrest was associ... ... hiện toàn bộ
IUBMB Life - Tập 48 Số 4 - Trang 425-428 - 1999
Geldanamycin Induces Heat Shock Protein Expression Through Activation of HSF1 in K562 Erythroleukemic CellsAbstract HSP90 is one of the most abundant heat shock proteins (HSPs) in eukaryotic cells and is found in complex with several regulatory proteins such as kinases and transcription factors. Geldanamycin (GA), a benzoquinone ansamycin, specifically binds to HSP90 and disrupts the interaction of HSP90 and target proteins. Thus, GA has been used as a specific inhibitor... ... hiện toàn bộ
IUBMB Life - Tập 48 Số 4 - Trang 429-433 - 1999
Đường đi Kennedy—Tổng hợp De novo của phosphatidylethanolamine và phosphatidylcholine Dịch bởi AI Tóm tắt Các glycerophospholipid phosphatidylcholine (PC) và phosphatidylethanolamine (PE) chiếm hơn 50% tổng số loài phospholipid trong màng eukaryote và do đó đóng vai trò quan trọng trong cấu trúc và chức năng của các màng này. Trong hầu hết các tế bào eukaryote, PC và PE được tổng hợp thông qua phản ứng aminocoholphosphotransferase, sử dụng sn... hiện toàn bộ
IUBMB Life - Tập 62 Số 6 - Trang 414-428 - 2010
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte LipolysisAbstract The related disorders of obesity and diabetes are increasing to epidemic proportions. The role of neutral lipid storage and hydrolysis, and hence the adipocyte, is central to understanding this phenomenon. The adipocyte holds the major source of stored energy in the body in the form of triacylglycerols (TAG). It has been known for over 35 years that the bre... ... hiện toàn bộ
IUBMB Life - Tập 56 Số 7 - Trang 379-385 - 2004
Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver diseaseAbstract Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in western countries, being considered the hepatic manifestation of metabolic syndrome. Cumulative lines of evidence suggest that olive oil, used as primary source of fat by Mediterranean populations, may play a key role in the observed health benefits on NAFLD. In thi... ... hiện toàn bộ
IUBMB Life - Tập 67 Số 1 - Trang 9-17 - 2015
Exenatide ameliorates inflammatory response in human rheumatoid arthritis fibroblast‐like synoviocytesAbstract Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology characterized by degradation of cartilage and bone, accompanied by unimpeded proliferation of synoviocytes of altered phenotype. In the present study, we investigated the involvement of the glucagon‐like peptide 1 (GLP‐1) receptor on human fibroblast‐like synoviocytes... ... hiện toàn bộ
IUBMB Life - Tập 71 Số 7 - Trang 969-977 - 2019
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