IUBMB Life

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Insights into Acinetobacter baumannii pathogenicity
IUBMB Life - Tập 63 Số 12 - Trang 1055-1060 - 2011
Gustavo M. Cerqueira, Anton Y. Peleg
AbstractAcinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a “red‐alert” human pathogen, primarily because of its exceptional ability...... hiện toàn bộ
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis
IUBMB Life - Tập 56 Số 7 - Trang 379-385 - 2004
John T. Tansey, Carole Sztalryd, Erica M. Hlavin, Alan R. Kimmel, Constantine Londos
AbstractThe related disorders of obesity and diabetes are increasing to epidemic proportions. The role of neutral lipid storage and hydrolysis, and hence the adipocyte, is central to understanding this phenomenon. The adipocyte holds the major source of stored energy in the body in the form of triacylglycerols (TAG). It has been known for over 35 years that the bre...... hiện toàn bộ
Mammalian polyamine metabolism and function
IUBMB Life - Tập 61 Số 9 - Trang 880-894 - 2009
Anthony E. Pegg
AbstractPolyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize th...... hiện toàn bộ
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
IUBMB Life - Tập 57 Số 4-5 - Trang 283-295 - 2005
Michael Karin, Ewen Gallagher
AbstractThe c‐Jun N‐terminal kinases (JNKs) were originally identified by their ability to phosphorylate c‐Jun in response to UV‐irradiation, but now are recognized as critical regulators of various aspects of mammalian physiology, including: cell proliferation, cell survival, cell death, DNA repair and metabolism. JNK‐mediated phosphorylation enhances the ability ...... hiện toàn bộ
4‐Hydroxynonenal (4‐HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4‐HNE also exert protective effects?
IUBMB Life - Tập 58 Số 5-6 - Trang 372-373 - 2006
Zhihua Chen, Etsuo Niki
ATP‐binding cassette transporters and cholesterol translocation
IUBMB Life - Tập 65 Số 6 - Trang 505-512 - 2013
Ge Li, Hongmei Gu, Dawei Zhang
AbstractCholesterol, a major component of mammalian cell membranes, plays important structural and functional roles. However, accumulation of excessive cholesterol is toxic to cells. Aberrant cholesterol trafficking and accumulation is the molecular basis for many diseases, such as atherosclerotic cardiovascular disease and Tangier's disease. Accumulation of excess...... hiện toàn bộ
Nitric Oxide and Reactive Oxygen Species in Parkinson's Disease
IUBMB Life - Tập 55 Số 6 - Trang 329-335 - 2003
Kim Tieu, Harry Ischiropoulos, Serge Przedborski
AbstractParkinson's disease is a neurodegenerative disorder of unknown pathogenesis. Oxidative stress has been proposed as one of several pathogenic hypotheses. Evidence for the participation of oxidative processes in the pathogenesis of Parkinson's disease have been obtained in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) model by the use of genetically...... hiện toàn bộ
31P NMR and AFM studies on the destabilization of cell and model membranes by the major bovine seminal plasma protein, PDC‐109
IUBMB Life - Tập 62 Số 11 - Trang 841-851 - 2010
Rajani S. Damai, Rajeshwer S. Sankhala, Anbazhagan Veerappan, Musti J. Swamy
AbstractThe effect of PDC‐109 binding to dimyristoylphosphatidylcholine (DMPC) and dipalmitoylphosphatidylglycerol (DPPG) multilamellar vesicles (MLVs) and supported membranes was investigated by 31P NMR spectroscopy and atomic force microscopy. Additionally, the effect of cholesterol on the binding of PDC‐109 to phosphatidylcholine (PC) membra...... hiện toàn bộ
Isolation of the transferrin receptor from human placenta
IUBMB Life - Tập 42 Số 2 - Trang 309-314 - 1997
Yu V. Kanevsky, L. P. Pozdnyakova, Yu V. Katukov, С Е Северин
AbstractThe transferrin receptor (TFR) has been detected in tissues characterised by a high degree of proliferation. We have developed a procedure for isolating TFR from human placental tissues by affinity chromatography on transferrin‐Sepharose. Using gel filtration and electrophoresis in 7% PAAG, it has been shown that the molecular mass of the protein is 180 kDa...... hiện toàn bộ
Geldanamycin Induces Cell Cycle Arrest in K562 Erythroleukemic Cells
IUBMB Life - Tập 48 Số 4 - Trang 425-428 - 1999
Hong Ro Kim, Chang Hoon Lee, Yung Hyun Choi, Ho Sung Kang, Han Do Kim
AbstractGeldanamycin (GA), a benzoquinone ansamycin, is one of the specific inhibitors of 90‐kDa heat shock protein and induces growth inhibition and apoptosis in certain cancer cell lines. We have investigated the mechanism of GA‐induced growth inhibition in K562 erythroleukemic cells. DNA flow‐cytometric analysis indicated that GA‐induced growth arrest was associ...... hiện toàn bộ
Tổng số: 52   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6