IUBMB Life

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Insights into Acinetobacter baumannii pathogenicity
IUBMB Life - Tập 63 Số 12 - Trang 1055-1060 - 2011
Gustavo M. Cerqueira, Anton Y. Peleg
AbstractAcinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a “red‐alert” human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abi... hiện toàn bộ
Platelet Interactions in Thrombosis
IUBMB Life - Tập 56 Số 1 - Trang 13-18 - 2004
Robert K. Andrews, Elizabeth E. Gardiner, Yang Shen, Michael C. Berndt
AbstractPatho/physiological platelet aggregate (thrombus) formation is initiated by engagement of platelet surface receptors, glycoprotein (GP)Ib‐IX‐V and GPVI that bind von Willebrand factor or collagen. Although beneficial in response to vascular injury by preventing blood loss (haemostasis), platelet aggregation in a sclerotic coronary artery or other diseased blood vessel (thrombosis) can caus... hiện toàn bộ
The metabolic landscape of cancer stem cells
IUBMB Life - Tập 67 Số 9 - Trang 687-693 - 2015
Ilaria Dando, Elisa Dalla Pozza, Giulia Biondani, Marco Cordani, Marta Palmieri, Massimo Donadelli
AbstractCancer stem cells (CSCs) are a sub‐population of quiescent cells endowed with self‐renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional che... hiện toàn bộ
Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease
IUBMB Life - Tập 67 Số 1 - Trang 9-17 - 2015
Paola Priore, Alessandro Cavallo, Antonio Gnoni, Fabrizio Damiano, Gabriele V. Gnoni, Luisa Siculella
AbstractNonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in western countries, being considered the hepatic manifestation of metabolic syndrome. Cumulative lines of evidence suggest that olive oil, used as primary source of fat by Mediterranean populations, may play a key role in the observed health benefits on NAFLD. In this review, we summarize the state ... hiện toàn bộ
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis
IUBMB Life - Tập 56 Số 7 - Trang 379-385 - 2004
John T. Tansey, Carole Sztalryd, Erica M. Hlavin, Alan R. Kimmel, Constantine Londos
AbstractThe related disorders of obesity and diabetes are increasing to epidemic proportions. The role of neutral lipid storage and hydrolysis, and hence the adipocyte, is central to understanding this phenomenon. The adipocyte holds the major source of stored energy in the body in the form of triacylglycerols (TAG). It has been known for over 35 years that the breakdown of TAG and release of free... hiện toàn bộ
Hsp27: Novel Regulator of Intracellular Redox State
IUBMB Life - Tập 52 Số 6 - Trang 303-307 - 2001
André‐Patrick Arrigo
AbstractSmall stress proteins are molecular chaperones that modulate the ability of cells to respond to several types of injuries. In this regard, a protection generated by the expression of mammalian small stress proteins against the cell death induced by oxidative stress has been described. This review summarizes the current knowledge of the protective mechanism generated by the expression of th... hiện toàn bộ
Glutathione S‐Transferase, Similar to Sigma Class, from Skin Secretions of Xenopus laevis
IUBMB Life - Tập 50 Số 3 - Trang 203-207 - 2000
Alfonso Pennelli, Saida Ortolano, Rossella Miele, T Renda, Paolo Sacchetta, Carmine Di Ilio, Maurizio Simmaco
AbstractUsing glutathione affinity chromatography followed by isoelectro‐focusing, we purified from the skin secretion of Xenopus laevis an isoenzyme of glutathione S‐transferase with an apparent subunit molecular mass of 22.5 kDa and an isoelectric point at pH 5.1. Its N‐terminal amino acid sequence was highly similar to that of the sigma class glutathione S‐transferase, which previously was demo... hiện toàn bộ
Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells
IUBMB Life - Tập 64 Số 9 - Trang 775-782 - 2012
Chengfu Zhou, Xuebing Li, Heng Sun, Bo Zhang, Yusong Han, Yi Jiang, Qiulin Zhuang, Jing Fang, Guohao Wu
AbstractPyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains unclear. The aim of this study is to investigate PKM2 expression and its possible role in CRC. We found that expression of PKM2 was increased in... hiện toàn bộ
Reactive Oxygen Species and Signal Transduction
IUBMB Life - Tập 52 Số 1 - Trang 3-6 - 2001
Toren Finkel
AbstractIncreasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulation. These ROS appear essential for a host of downstream signaling events... hiện toàn bộ
Molecular basis of antibody‐mediated neutralization and protection against flavivirus
IUBMB Life - Tập 68 Số 10 - Trang 783-791 - 2016
Lianpan Dai, Qihui Wang, Jianxun Qi, Yi Shi, Jinghua Yan, George F. Gao
AbstractAntibody‐mediated humoral immunity plays a pivotal role in flavivirus control. Neutralizing antibodies targeting viral envelope (E) protein, provide protection against flaviviruses in vivo but can also promote virus infection by antibody‐dependent enhancement when antibodies are weakly neutralizing or in subneutralizing concentrations. The molecular basis for antibody‐mediated virus neutra... hiện toàn bộ
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