Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells

IUBMB Life - Tập 64 Số 9 - Trang 775-782 - 2012
Chengfu Zhou1, Xuebing Li, Heng Sun, Bo Zhang, Yusong Han, Yi Jiang, Qiulin Zhuang, Jing Fang, Guohao Wu
1Department of Surgery, Zhongshan Hospital, Fudan University School of Medicine, Shanghai 200032, China.

Tóm tắt

AbstractPyruvate kinase type M2 (PKM2) has been reported to be involved in aerobic glycolysis and cell growth in various tumors. However, the expression pattern of PKM2 in colorectal cancer (CRC) and the correlation between PKM2 expression and CRC remains unclear. The aim of this study is to investigate PKM2 expression and its possible role in CRC. We found that expression of PKM2 was increased in CRC and the increased PKM2 expression was associated with later stage and lymph metastasis of the tumors. Knockdown of PKM2 suppressed the aerobic glycolysis and decreased lactate production of colon cancer RKO cells. Knockdown of PKM2 repressed proliferation and migration of the cells. Inhibition of PKM2 suppressed xenograft tumor growth of RKO cells in vivo. These results suggest that the expression of PKM2 plays a critical role in development of CRC, and it may provide a growth advantage for colon cancer cells. Thus, PKM2 might be a potential therapeutic target for CRC. © 2012 IUBMB Life, 64(9): 775–782, 2012

Từ khóa


Tài liệu tham khảo

10.1016/j.canlet.2008.08.007

10.1002/pro.505

10.1007/s10863-007-9085-y

Goetze K., 2011, Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release, Int. J. Oncol., 39, 453

10.1038/nature10167

10.1038/480190a

10.1126/science.123.3191.309

10.1016/j.ygeno.2004.08.010

10.1038/nm1052

10.1038/nature06734

10.1016/S0969-2126(98)00021-5

10.1016/j.semcancer.2005.04.009

10.1016/S0065-230X(08)61022-2

10.1038/nature06667

10.1126/scisignal.2000431

10.1073/pnas.96.4.1291

10.1038/sj.onc.1204792

10.1371/journal.pone.0028234

10.1073/pnas.1106704108

10.1007/s00432-009-0652-y

10.3322/caac.20073

10.1093/jjco/hyq125

10.1093/annonc/mdq043

10.1053/j.gastro.2009.09.049

10.1093/carcin/bgn244

10.1002/ijc.23512

10.1136/jcp.2004.018150

10.18632/oncotarget.278

10.1016/j.yexcr.2009.06.024

10.1016/S1389-0344(01)00107-1

10.1097/01.MP.0000051582.75890.2D

Katayama M., 2003, Laminin gamma2‐chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion, Cancer Res., 63, 222

10.1128/MCB.26.4.1297-1306.2006

10.1016/S0360-3016(01)01630-3

Walenta S., 2000, High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers, Cancer Res., 60, 916

10.1159/000183250

10.4161/cc.9.17.12731

10.1007/s00432-009-0590-8

10.2967/jnumed.107.047258

10.1038/nrc1478

Goetze K., 2011, Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release, Int. J. Oncol., 39, 453

10.1215/15228517-2008-106

10.1111/j.1743-6109.2006.00127.x

10.1158/0008-5472.CAN-10-2828

10.1007/s10555-007-9064-0

10.1111/j.1349-7006.2010.01562.x

Thông tin
Thông tin xuất bản

IUBMB Life

Tập 64 Số 9

775-782

Thông tin tác giả