IUBMB Life
SCIE-ISI SCOPUS (1999-2025)
1521-6543
1521-6551
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Blackwell
Lĩnh vực:
Molecular BiologyClinical BiochemistryGeneticsBiochemistryCell Biology
Các bài báo tiêu biểu
The extraordinary ligand binding properties of human serum albumin
Tập 57 Số 12 - Trang 787-796 - 2005
Mammalian polyamine metabolism and function
Tập 61 Số 9 - Trang 880-894 - 2009
AbstractPolyamines are ubiquitous small basic molecules that play multiple
essential roles in mammalian physiology. Their cellular content is highly
regulated and there is convincing evidence that altered metabolism is
involvement in many disease states. Drugs altering polyamine levels may
therefore have a variety of important targets. This review will summarize the
current state of understanding ...
Antibacterial components of honey
Tập 64 Số 1 - Trang 48-55 - 2012
AbstractThe antibacterial activity of honey has been known since the 19th
century. Recently, the potent activity of honey against antibiotic‐resistant
bacteria has further increased the interest for application of honey, but
incomplete knowledge of the antibacterial activity is a major obstacle for
clinical applicability. The high sugar concentration, hydrogen peroxide, and the
low pH are well‐kno...
Đường đi Kennedy—Tổng hợp De novo của phosphatidylethanolamine và phosphatidylcholine Dịch bởi AI
Tập 62 Số 6 - Trang 414-428 - 2010
Tóm tắtCác glycerophospholipid phosphatidylcholine (PC) và
phosphatidylethanolamine (PE) chiếm hơn 50% tổng số loài phospholipid trong màng
eukaryote và do đó đóng vai trò quan trọng trong cấu trúc và chức năng của các
màng này. Trong hầu hết các tế bào eukaryote, PC và PE được tổng hợp thông qua
phản ứng aminocoholphosphotransferase, sử dụng sn‐1,2‐diradylglycerol và
CDP‐choline hoặc CDP‐ethanola...
The monocarboxylate transporter family—Role and regulation
Tập 64 Số 2 - Trang 109-119 - 2012
AbstractMonocarboxylate transporter (MCT) isoforms 1–4 catalyze the
proton‐linked transport of monocarboxylates such as L‐lactate across the plasma
membrane, whereas MCT8 and MCT10 are thyroid hormone and aromatic amino acid
transporters, respectively. The importance of MCTs is becoming increasingly
evident as their extensive physiological and pathological roles are revealed.
MCTs 1–4 play essenti...
DDT, pyrethrins, pyrethroids and insect sodium channels
Tập 59 Số 3 - Trang 151-162 - 2007
AbstractThe long term use of many insecticides is continually threatened by the
ability of insects to evolve resistance mechanisms that render the chemicals
ineffective. Such resistance poses a serious threat to insect pest control both
in the UK and worldwide. Resistance may result from either an increase in the
ability of the insect to detoxify the insecticide or by changes in the target
protein...
Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival
Tập 64 Số 5 - Trang 362-369 - 2012
AbstractGlucose‐6‐phosphate dehydrogenase (G6PD) is the rate‐limiting enzyme of
the pentose phosphate pathway. Many scientists think that the roles and
regulation of G6PD in physiology and pathophysiology have been well established
as the enzyme was first identified 80 years ago. And that G6PD has been
extensively studied especially with respect to G6PD deficiency and its
association with hemolysi...
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
Tập 57 Số 4-5 - Trang 283-295 - 2005
AbstractThe c‐Jun N‐terminal kinases (JNKs) were originally identified by their
ability to phosphorylate c‐Jun in response to UV‐irradiation, but now are
recognized as critical regulators of various aspects of mammalian physiology,
including: cell proliferation, cell survival, cell death, DNA repair and
metabolism. JNK‐mediated phosphorylation enhances the ability of c‐Jun, a
component of the AP‐1...
Reactive Oxygen Species and Signal Transduction
Tập 52 Số 1 - Trang 3-6 - 2001
AbstractIncreasing evidence suggests a role for intracellular reactive oxygen
species (ROS) as mediators of normal and pathological signal transduction
pathways. In particular, a growing list of recent reports have demonstrated a
rapid and significant increases in intracellular ROS following growth factor or
cytokine stimulation. These ROS appear essential for a host of downstream
signaling events...