Glucose‐6‐phosphate dehydrogenase, NADPH, and cell survival

IUBMB Life - Tập 64 Số 5 - Trang 362-369 - 2012
Robert C. Stanton1,2,3,4
1Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
2Harvard Medical School
3Renal Section, Joslin Diabetes Center, Boston, MA, US
4Tel.: +617-309-2477.

Tóm tắt

AbstractGlucose‐6‐phosphate dehydrogenase (G6PD) is the rate‐limiting enzyme of the pentose phosphate pathway. Many scientists think that the roles and regulation of G6PD in physiology and pathophysiology have been well established as the enzyme was first identified 80 years ago. And that G6PD has been extensively studied especially with respect to G6PD deficiency and its association with hemolysis, and with respect to the role G6PD plays in lipid metabolism. But there has been a growing understanding of the central importance of G6PD to cellular physiology as it is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Indeed G6PD is essential for cell survival. It has also become evident that G6PD is highly regulated by many signals that affect transcription, post‐translation, intracellular location, and interactions with other protein. Pathophysiologic roles for G6PD have also been identified in such disease processes as diabetes, aldosterone‐induced endothelial dysfunction, cancer, and others. It is now clear that G6PD is under complex regulatory control and of central importance to many cellular processes. In this review the biochemistry, regulatory signals, physiologic roles, and pathophysiologic roles for G6PD that have been elucidated over the past 20 years are discussed. 2012 IUBMB IUBMB Life, 2012

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Tài liệu tham khảo

10.1016/0076-6879(55)01046-X

10.1042/bst0301091

10.1016/j.bcmd.2008.12.005

10.1002/iub.137

10.1016/S0969-2126(00)00104-0

10.1096/fasebj.8.2.8119488

10.1002/cbf.290040403

Ho H. Y., 2005, G6PD—an old bottle with new wine, Chang Gung Med. J., 28, 606

10.1016/0006-291X(76)91164-5

10.1126/science.1850548

10.1073/pnas.85.3.812

10.1038/emboj.2010.330

10.1038/ncb2172

10.1016/S0021-9258(18)98918-0

Tian W. N., 1994, Signal transduction proteins that associate with the platelet‐derived growth factor (PDGF) receptor mediate the PDGF‐induced release of glucose‐6‐phosphate dehydrogenase from permeabilized cells, J. Biol. Chem., 269, 14798, 10.1016/S0021-9258(17)36695-4

10.1161/ATVBAHA.109.184812

10.1002/ijc.23460

10.1016/j.molcel.2010.06.022

10.1074/jbc.273.24.14968

10.1016/j.bcp.2007.01.004

10.1016/j.cell.2006.05.036

Costa Rosa L. F., 1995, Effect of adrenaline and phorbol myristate acetate or bacterial lipopolysaccharide on stimulation of pathways of macrophage glucose, glutamine and O2 metabolism. Evidence for cyclic AMP‐dependent protein kinase mediated inhibition of glucose‐6‐phosphate dehydrogenase and activation of NADP+‐dependent ‘malic’ enzyme, Biochem. J., 310, 709, 10.1042/bj3100709

10.1152/ajprenal.00076.2005

10.1074/jbc.M007505200

10.1038/nm1545

10.1074/jbc.M505531200

10.1016/S0306-9877(98)90271-7

10.1016/j.acthis.2009.03.003

10.1111/j.1365-2613.2008.00582.x

10.1074/jbc.273.17.10609

10.1152/ajpcell.1999.276.5.C1121

10.1002/j.1460-2075.1995.tb00205.x

10.1093/emboj/cdf426

10.1002/(SICI)1097-0215(20000315)85:6<857::AID-IJC20>3.0.CO;2-U

10.1016/S0891-5849(00)00331-2

10.1096/fj.09-136572

10.1074/jbc.M301293200

10.1161/01.ATV.0000056744.26901.BA

10.1089/ars.2009.2615

10.1164/rccm.2206007

10.1016/S0074-7696(06)60002-8

10.1016/j.freeradbiomed.2010.05.002

10.4077/CJP.2011.AMM006

10.1016/S0027-5107(96)00222-9

10.1096/fj.09-135731

10.1007/s00134-002-1628-4

10.1016/j.lfs.2005.10.022

10.1016/j.yjmcc.2010.05.014

10.1111/j.1464-5491.2005.01499.x

10.1152/ajpheart.01142.2008

10.1016/j.freeradbiomed.2009.01.028

10.1210/en.2010-0606

10.1016/j.cell.2007.06.044

Niazi G. A., 1991, Glucose‐6‐phosphate dehydrogenase deficiency and diabetes mellitus, Int. J. Hematol., 54, 295

10.1111/j.1464-5491.1985.tb00611.x

10.1007/s00125-011-2099-3

Gaskin R. S., 2001, G6PD deficiency: its role in the high prevalence of hypertension and diabetes mellitus, Ethn. Dis., 11, 749

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IUBMB Life

Tập 64 Số 5

362-369

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