Antibacterial components of honey
Tóm tắt
The antibacterial activity of honey has been known since the 19th century. Recently, the potent activity of honey against antibiotic‐resistant bacteria has further increased the interest for application of honey, but incomplete knowledge of the antibacterial activity is a major obstacle for clinical applicability. The high sugar concentration, hydrogen peroxide, and the low pH are well‐known antibacterial factors in honey and more recently, methylglyoxal and the antimicrobial peptide bee defensin‐1 were identified as important antibacterial compounds in honey. The antibacterial activity of honey is highly complex due to the involvement of multiple compounds and due to the large variation in the concentrations of these compounds among honeys. The current review will elaborate on the antibacterial compounds in honey. We discuss the activity of the individual compounds, their contribution to the complex antibacterial activity of honey, a novel approach to identify additional honey antibacterial compounds, and the implications of the novel developments for standardization of honey for medical applications. © 2011 IUBMB IUBMB Life, 2011.s
Từ khóa
Tài liệu tham khảo
Schepartz A. I., 1964, The glucose oxidase of honey. I. Purification and some general properties of the enzyme, Biochim. Biophys. Acta, 85, 228
Huidobro J. F., 2005, Precise method for the measurement of catalase activity in honey, J. AOAC Int., 88, 800, 10.1093/jaoac/88.3.800
Casteels‐Josson K., 1994, Acute transcriptional response of the honeybee peptide‐antibiotics gene repertoire and required post‐translational conversion of the precursor structures, J. Biol. Chem., 269, 28569, 10.1016/S0021-9258(19)61943-5
Fujiwara S., 1990, A potent antibacterial protein in royal jelly. Purification and determination of the primary structure of royalisin, J. Biol.Chem., 265, 11333, 10.1016/S0021-9258(19)38596-5
Aljadi A. M., 2003, Isolation and identification of phenolic acids in Malaysian honey with antibacterial properties, Turkish J. Med. Sci., 33, 229