Insights into Acinetobacter baumannii pathogenicity

IUBMB Life - Tập 63 Số 12 - Trang 1055-1060 - 2011
Gustavo M. Cerqueira1, Anton Y. Peleg2,3,1,4
1Faculty of Medicine, Nursing and Health Sciences, Department of Microbiology, Monash University, Melbourne, Australia
2Department of Infectious Diseases, Alfred Hospital, Melbourne, Australia
3Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA
4Tel: +61-3-99029159

Tóm tắt

AbstractAcinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a “red‐alert” human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life‐threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism. © 2011 IUBMB IUBMB Life, 63(12): 1055–1060, 2011

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IUBMB Life

Tập 63 Số 12

1055-1060

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