The metabolic landscape of cancer stem cells

IUBMB Life - Tập 67 Số 9 - Trang 687-693 - 2015
Ilaria Dando1, Elisa Dalla Pozza1, Giulia Biondani1, Marco Cordani1, Marta Palmieri1, Massimo Donadelli1
1Department of Life and Reproduction Sciences, Section of Biochemistry, University of Verona, Verona, Italy

Tóm tắt

AbstractCancer stem cells (CSCs) are a sub‐population of quiescent cells endowed with self‐renewal properties that can sustain the malignant behavior of the tumor mass giving rise to more differentiated cancer cells. For this reason, the specific killing of CSCs represents one of the most important challenges of the modern molecular oncology. However, their particular resistance to traditional chemotherapy and radiotherapy imposes a thorough understanding of their biological and biochemical features. The metabolic peculiarities of CSCs may be a therapeutic and diagnostic opportunity in cancer research. In this review, we summarize the most significant discoveries on the metabolism of CSCs describing and critically analyzing the studies supporting either glycolysis or mitochondrial oxidative phosphorylation as a primary source of energy for CSCs. © 2015 IUBMB Life, 67(9):687–693, 2015

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IUBMB Life

Tập 67 Số 9

687-693

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