Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease

IUBMB Life - Tập 67 Số 1 - Trang 9-17 - 2015
Paola Priore1, Alessandro Cavallo1, Antonio Gnoni2, Fabrizio Damiano1, Gabriele V. Gnoni1, Luisa Siculella1
1Department of Biological and Environmental Sciences and Technologies, Laboratory of Biochemistry and Molecular Biology, University of Salento, Lecce, Italy
2Department of Basical Medical Sciences, Neurosciences and Sensory Organs, University of Bari Aldo Moro, Bari, Italy.

Tóm tắt

AbstractNonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in western countries, being considered the hepatic manifestation of metabolic syndrome. Cumulative lines of evidence suggest that olive oil, used as primary source of fat by Mediterranean populations, may play a key role in the observed health benefits on NAFLD. In this review, we summarize the state of the art of the knowledge on the protective role of both major and minor components of olive oil on lipid metabolism during NAFLD. In particular, the biochemical mechanisms responsible for the increase or decrease in hepatic lipid content are critically analyzed, taking into account that several studies have often provided different and/or conflicting results in animal models fed on olive oil‐enriched diet. In addition, new findings that highlight the hypolipidemic and the antisteatotic actions of olive oil phenols are presented. As mitochondrial dysfunction plays a key role in the pathogenesis of NAFLD, the targeting of these organelles with olive oil phenols as a powerful therapeutic approach is also discussed. © 2015 IUBMB Life, 67(1):9–17, 2015

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IUBMB Life

Tập 67 Số 1

9-17

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