Human and Experimental Toxicology
SCOPUS (1981-2023)SCIE-ISI
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Cơ quản chủ quản: SAGE Publications Ltd , SAGE Publications Inc.
Lĩnh vực:
ToxicologyMedicine (miscellaneous)Health, Toxicology and Mutagenesis
Các bài báo tiêu biểu
Defining hormesis Much confusion surrounds the concept of hormesis and what its biological meaning represents. This paper provides a definition of hormesis that addresses its historical foundations, quantitative features, and under-lying evolutionary and toxicologically based mechanistic strategies. Hormesis should be considered an adaptive response characterized by biphasic dose responses of generally sim... ...
Tập 21 Số 2 - Trang 91-97 - 2002
Particulate matter properties and health effects: consistency of epidemiological and toxicological studies Identifying the ambient particulate matter (PM) fractions or constituents, critically involved in eliciting adverse health effects, is crucial to the implementation of more cost-efficient abatement strategies to improve air quality. This review focuses on the importance of different particle properties for PM-induced effects, and whether there is consistency in the results from epidemiolo... ...
Tập 25 Số 10 - Trang 559-579 - 2006
Arsenic neurotoxicity — A review Arsenic (As) is one of the oldest poisons known to men. Its applications throughout history are wide and varied: murder, make-up, paint and even as a pesticide. Chronic As toxicity is a global environmental health problem, affecting millions of people in the USA and Germany to Bangladesh and Taiwan. Worldwide, As is released into the environment by smelting of various metals, combustion o... ...
Tập 26 Số 10 - Trang 823-832 - 2007
The toxicity of cyanobacterial toxins in the mouse: I Microcystin-LR Blooms of cyanobacteria or blue-green algae are known to have caused poisoning in fish, waterfowl, animals and man. One of the toxins responsible for this is the hepatotoxin microcystin-LR which has been found to occur in blooms present intermittently in sources used for domestic water supplies. Three sets of experiments were undertaken to investigate the acute toxicity of microcystin-LR ... ...
Tập 18 Số 3 - Trang 162-167 - 1999
Cyanide: critical issues in diagnosis and treatment The concern of a terrorist attack using cyanide, as well as the gradual awareness of cyanide poisoning in fire victims, has resulted in a renewed interest in the diagnosis and treatment of cyanide poisoning. The formerly academic presentation of cyanide poisoning must be replaced by more useful knowledge, which will allow emergency physicians and rescue workers to strongly suspect cyanide... ...
Tập 26 Số 3 - Trang 191-201 - 2007
Defining a tolerable concentration of methanol in alcoholic drinks Methanol, a potent toxicant in humans, occurs naturally at a low level in most alcoholic beverages without causing harm. However, illicit drinks made from “industrial methylated spirits” [5% (v/v) methanol:95% (v/v) ethanol] can cause severe and even fatal illness. Since documentation of a no-adverse-effect level for methanol is nonexistent in the literature a key question, from the publi... ...
Tập 20 Số 11 - Trang 563-568 - 2001
Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning 1 In vitro studies with human erythrocyte acetylcholin esterase (AChE) and the mouse diaphragm model were performed to unravel the various microscopic reaction parameters that contribute to the dynamic equilibrium of AChE inhibition, ageing and reactivation. These data may help to define more precisely the indications and limitations of oxime therapy in organophosphate (OP) poisoning. ...
Tập 16 Số 8 - Trang 466-472 - 1997
Toxicokinetics of Paraquat in Humans 1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associate... ...
Tập 9 Số 1 - Trang 5-12 - 1990
Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to preve... ...
Tập 25 Số 3 - Trang 111-118 - 2006
Effects of Polychlorinated Biphenyls (PCBs) and Dioxins on Growth and Development Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human studies, tries to answer this question. Animal studie... ...
Tập 13 Số 12 - Trang 900-906 - 1994