Human and Experimental Toxicology

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Fipronil-induced genotoxicity and DNA damage in vivo: Protective effect of vitamin E
Human and Experimental Toxicology - Tập 36 Số 5 - Trang 508-519 - 2017
Prarabdh C. Badgujar, Selkar Na, GA Chandratre, NN Pawar, V C Dighe, ST Bhagat, AG Telang, GR Vanage
Fipronil, an insecticide of the phenylpyrazole class has been classified as a carcinogen by United States Environmental Protection Agency, yet very limited information is available about its genotoxic effects. Adult male and female animals were gavaged with various doses of fipronil (2.5, 12.5, and 25 mg/kg body weight (bw)) to evaluate micronucleus test (mice), chromosome aberration (CA)...... hiện toàn bộ
Chemosensory irritations and pulmonary effects of acute exposure to emissions from oriented strand board
Human and Experimental Toxicology - Tập 30 Số 9 - Trang 1204-1221 - 2011
Richard Gminski, R. Marutzky, Sebastian Kevekordes, Frank Fuhrmann, Werner Bürger, Dieter Hauschke, Winfried Ebner, Volker Mersch‐Sundermann
Due to the reduction of air change rates in low-energy houses, the contribution to indoor air quality of volatile organic compounds (VOCs) emitting from oriented strand boards (OSB) has become increasingly important. The aim of this study was to evaluate sensory irritations, pulmonary effects and odor annoyance of emissions from OSB in healthy human volunteers compared to clean air. Twent...... hiện toàn bộ
Decreased paraoxonase 1 activity and increased oxidative stress in low lead−exposed workers
Human and Experimental Toxicology - Tập 30 Số 9 - Trang 1196-1203 - 2011
Thinnakorn Permpongpaiboon, Amar Nagila, Phannee Pidetcha, Kulwadee Tuangmungsakulchai, Soontharee Tantrarongroj, Sureerut Porntadavity
Paraoxonase 1 (PON1) has been proposed as an antioxidant enzyme. Although lead-inhibited PON1 activity has been demonstrated mostly based on in vitro experiments, it is uncertain whether this phenomenon is relevant in pathogenesis of lead-induced oxidative stress in the lead exposure. We examined associations of blood lead levels (BLL) and PON1 activity along with oxidative stress paramet...... hiện toàn bộ
Low-level environmental exposure to lead and renal adverse effects: A cross-sectional study in the population of children bordering the Mbeubeuss landfill near Dakar, Senegal
Human and Experimental Toxicology - Tập 31 Số 12 - Trang 1280-1291 - 2012
Marta Cabral, Denis Dieme, Anthony Verdin, Guillaume Garçon, Mamadou Fall, S. Bouhsina, Dorothée Dewaële, Fabrice Cazier, A Tall-Dia, A. Diouf, Pirouz Shirali
This study deals with the health effects within a child population, neighbouring a landfill. After detecting metals in soil and air samples collected in the surroundings of the landfill and in a control site, we have studied: (i) levels of lead (Pb) and exposure biomarkers in blood and urine, (ii) oxidative stress biomarkers and (iii) renal injury by applying a set of early effect biomark...... hiện toàn bộ
Blood lead levels and enzymatic biomarkers of environmental lead exposure in children in Córdoba, Argentina, after the ban of leaded gasoline
Human and Experimental Toxicology - Tập 32 Số 5 - Trang 449-463 - 2013
SA Martínez, Leonardo Simonella, C. Hansen, S Rivolta, LM Cancela, Miriam B. Virgolini
Lead (Pb) is a developmental neurotoxicant found in industrial activities, many of them already prohibited worldwide. This study aimed to evaluate current blood Pb (PbB) levels in children in Cordoba, Argentina, and to compare these with similar studies performed before Pb was banned in gasoline in 1996. We also sought to identify mechanistically relevant biomarkers by measuring δ-aminole...... hiện toàn bộ
Delta-aminolevulinic acid dehydratase inhibition and oxidative stress in relation to blood lead among urban adolescents
Human and Experimental Toxicology - Tập 25 Số 9 - Trang 547-553 - 2006
Maqusood Ahamed, S K Verma, Awanish Kumar, M.K.J. Siddiqui
To explore lead-induced oxidative stress among urban adolescents, the present study, the first from India, was designed to determine the proportion of urban adolescents with blood lead > 10 μg/dL and its impact on selected oxidative stress parameters and delta-aminolevulinic acid dehydratase (δ-ALAD) inhibition, which could be used as biomarkers of lead intoxication. A total of 39, urb...... hiện toàn bộ
A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats
Human and Experimental Toxicology - Tập 35 Số 12 - Trang 1286-1304 - 2016
Anurag Kumar Srivastav, Mahadeo Kumar, Nasreen Ghazi Ansari, Abhishek Kumar Jain, Jai Shankar, Nidhi Arjaria, Pankaj Jagdale, Dhirendra Singh
The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and 48 h and 14 days posttreatment. The histopathological evaluations of ti...... hiện toàn bộ
Caffeic acid abrogates 1,3-dichloro-2-propanol-induced hepatotoxicity by upregulating nuclear erythroid-related factor 2 and downregulating nuclear factor-kappa B
Human and Experimental Toxicology - Tập 38 Số 9 - Trang 1092-1101 - 2019
TO Ajiboye, RA Ajala-Lawal, AB Adeyiga
1,3-dichloro-2-propanol is a food-borne contaminant reported to cause liver injury. In this study, we evaluated the protective influence of caffeic acid on 1,3-dichloro-2-propanol-induced hepatotoxicity in rats. Rats were randomized into five groups (A–E). Rats received distilled water or caffeic acid (10 or 20 mg/kg body weight) for 7 days. In addition, rats were challenged with 1,3-dich...... hiện toàn bộ
Toxicological features of deliberate self-poisonings
Human and Experimental Toxicology - Tập 23 Số 7 - Trang 331-337 - 2004
Yedidia Bentur, Bianca Raikhlin-Eisenkraft, Michal Lavee
Background: Deliberate self-poisoning (DSP) is a major health problem with increasing incidence mainly among young people. Objective: To examine the clinical and toxicological characteristics of DSP, it is compared to unintentional (non-DSP) exposures and those characteristics which might be associated with increased toxicological risk are identified. Methods: Two-year retrospective poiso...... hiện toàn bộ
Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: A cross-sectional pilot study in women from the Chihuahua State, Mexico
Human and Experimental Toxicology - Tập 28 Số 8 - Trang 451-459 - 2009
Brenda L. Acosta‐Maldonado, Blanca Sánchez‐Ramírez, Sandra A. Reza‐López, Margarita Levario‐Carrillo
It is known that pesticides cross the placental barrier and can cause alterations in the development of placental structures resulting in adverse effects in reproduction. The objectives of this study were to investigate the effects of pesticide exposure during pregnancy on placental maturity and to evaluate the relationship between placental maturity, gestational age and birth weight. We ...... hiện toàn bộ
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