Human and Experimental Toxicology

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N-nitrosodimethylamine (NDMA) induced apoptosis dependent on Fas/FasL complex in human leukocytes
Human and Experimental Toxicology - Tập 38 Số 5 - Trang 578-587 - 2019
Agnieszka Iwaniuk, Kamil Grubczak, Wioletta Ratajczak–Wrona, Marzena Garley, Karolina Nowak, Ewa Jabłońska
Objective:To investigate the mechanism of apoptosis dependent on the Fas/FasL (Fas ligand) complex in the presence of N-nitrosodimethylamine (NDMA) in human leukocytes.Methods:Polymorphonuclear neutrophils (PMNs) and peripheral blood mononuclear cells (PBMCs) were isolated form whole blood by ...... hiện toàn bộ
Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: A cross-sectional pilot study in women from the Chihuahua State, Mexico
Human and Experimental Toxicology - Tập 28 Số 8 - Trang 451-459 - 2009
Brenda L. Acosta‐Maldonado, Blanca Sánchez‐Ramírez, Sandra A. Reza‐López, Margarita Levario‐Carrillo
It is known that pesticides cross the placental barrier and can cause alterations in the development of placental structures resulting in adverse effects in reproduction. The objectives of this study were to investigate the effects of pesticide exposure during pregnancy on placental maturity and to evaluate the relationship between placental maturity, gestational age and birth weight. We ...... hiện toàn bộ
Protective effect of gallic acid on alloxan-induced oxidative stress and osmotic fragility in rats
Human and Experimental Toxicology - Tập 33 Số 6 - Trang 638-649 - 2014
Kunka Mohanram Ramkumar, RS Vijayakumar, Pachamuthu Vanitha, Natarajan Suganya, C. Manjula, P. Rajaguru, S Sivasubramanian, P. Gunasekaran
In the present study, we investigated the antioxidant effect of gallic acid (GA) on membrane lipid peroxidation and osmotic fragility in alloxan-induced diabetic Wistar rats. GA was administered orally at doses of 5, 10, and 20 mg/kg body weight for 45 days, after which liver and kidney tissues were analyzed for the degree of lipid peroxidation, reduced glutathione, and the activities of ...... hiện toàn bộ
Mechanisms of muscular electrophysiological and mitochondrial dysfunction following exposure to malathion, an organophosphorus pesticide
Human and Experimental Toxicology - Tập 33 Số 3 - Trang 251-263 - 2014
Somayyeh Karami‐Mohajeri, Mohammad Reza Hadian, Shamileh Fouladdel, Ebrahim Azizi, M H Ghahramani, Reshad Hosseini, Mohammad Abdollahi
Muscle dysfunction in acute organophosphorus (OP) poisoning is a cause of death in human. The present study was conducted to identify the mechanism of action of OP in terms of muscle mitochondrial dysfunction. Electromyography (EMG) was conducted on rats exposed to the acute oral dose of malathion (400 mg/kg) that could inhibit acetylcholinesterase activity up to 70%. The function of mito...... hiện toàn bộ
Effects of Polychlorinated Biphenyls (PCBs) and Dioxins on Growth and Development
Human and Experimental Toxicology - Tập 13 Số 12 - Trang 900-906 - 1994
P.J.J. Sauer, Marcel Huisman, Corine Koopman-Esseboom, D.C. Morse, A.E. Smits-van Prooije, K.J. van de Berg, L.G.M.T. Tuinstra, C.G. Van der Paauw, E.R. Boersma, Nynke Weisglas‐Kuperus, Jan Lammers, B.M. Kulig, Abraham Brouwer
Polychlorinated biphenyls (PCBs) and dioxins are potentially toxic compounds which occur widely in the environment. Their effects on the growth and development of infants at the levels currently found in highly industrialised western countries is not well known. This Dutch multicenter study, combining animal and human studies, tries to answer this question. Animal studie...... hiện toàn bộ
Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis
Human and Experimental Toxicology - Tập 39 Số 10 - Trang 1364-1373 - 2020
Emel Öztürk, Emin Kaymak, Ali Tuğrul Akın, Derya Karabulut, Hümeyra Ünsal, Birkan Yakan
Background: Doxorubicin (DOX) is used for treatment of many cancer types. Thymoquinone (THQ) is a powerful antioxidant agent used for reducing side effects of several drugs. The aim of this study is to determine possible therapeutic effects of THQ on doxorubicin-induced testicular toxicity in rats. Methods:... hiện toàn bộ
Defining hormesis
Human and Experimental Toxicology - Tập 21 Số 2 - Trang 91-97 - 2002
Edward J. Calabrese, Linda A. Baldwin
Much confusion surrounds the concept of hormesis and what its biological meaning represents. This paper provides a definition of hormesis that addresses its historical foundations, quantitative features, and under-lying evolutionary and toxicologically based mechanistic strategies. Hormesis should be considered an adaptive response characterized by biphasic dose responses of generally sim...... hiện toàn bộ
Particulate matter properties and health effects: consistency of epidemiological and toxicological studies
Human and Experimental Toxicology - Tập 25 Số 10 - Trang 559-579 - 2006
Per E. Schwarze, Johan Øvrevik, Marit Låg, Magne Refsnes, Per Nafstad, Ragna Bogen Hetland, Erik Dybing
Identifying the ambient particulate matter (PM) fractions or constituents, critically involved in eliciting adverse health effects, is crucial to the implementation of more cost-efficient abatement strategies to improve air quality. This review focuses on the importance of different particle properties for PM-induced effects, and whether there is consistency in the results from epidemiolo...... hiện toàn bộ
A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats
Human and Experimental Toxicology - Tập 35 Số 12 - Trang 1286-1304 - 2016
Anurag Kumar Srivastav, Mahadeo Kumar, Nasreen Ghazi Ansari, Abhishek Kumar Jain, Jai Shankar, Nidhi Arjaria, Pankaj Jagdale, Dhirendra Singh
The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. The hematological, biochemical, and urine parameters were accessed at 24 and 48 h and 14 days posttreatment. The histopathological evaluations of ti...... hiện toàn bộ
Fipronil-induced genotoxicity and DNA damage in vivo: Protective effect of vitamin E
Human and Experimental Toxicology - Tập 36 Số 5 - Trang 508-519 - 2017
Prarabdh C. Badgujar, Selkar Na, GA Chandratre, NN Pawar, V C Dighe, ST Bhagat, AG Telang, GR Vanage
Fipronil, an insecticide of the phenylpyrazole class has been classified as a carcinogen by United States Environmental Protection Agency, yet very limited information is available about its genotoxic effects. Adult male and female animals were gavaged with various doses of fipronil (2.5, 12.5, and 25 mg/kg body weight (bw)) to evaluate micronucleus test (mice), chromosome aberration (CA)...... hiện toàn bộ
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