Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: A cross-sectional pilot study in women from the Chihuahua State, Mexico

Human and Experimental Toxicology - Tập 28 Số 8 - Trang 451-459 - 2009
Brenda L. Acosta‐Maldonado1, Blanca Sánchez‐Ramírez2, Sandra A. Reza‐López3, Margarita Levario‐Carrillo4
1Medical Research Unit in Clinical Epidemiology of the Mexican Social Security Institute, 3 Ave. Ocampo y Deza y Ulloa S/N, Colonia Centro, Chihuahua, Mexico.
2Graduate Program in Biotechnology, Faculty of Chemical Sciences, Autonomous University of Chihuahua, Apdo. Postal 1542-C, Chihuahua, Mexico
3Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
4Medical Research Unit in Clinical Epidemiology of the Mexican Social Security Institute, Chihuahua, Mexico,

Tóm tắt

It is known that pesticides cross the placental barrier and can cause alterations in the development of placental structures resulting in adverse effects in reproduction. The objectives of this study were to investigate the effects of pesticide exposure during pregnancy on placental maturity and to evaluate the relationship between placental maturity, gestational age and birth weight. We collected the placentas from singleton pregnancies from women exposed (n = 9) and non-exposed (n = 45 full-term and n = 31 preterm) to pesticides as evaluated geographically, by questionnaire and by acetylcholinesterase levels. Placental morphometry from the central and peripheral regions was examined by microscopy and staining with hematoxylin and eosin. The placental maturity index (PMI) was estimated by dividing the number of epithelial plates in terminal villi to their thickness in 1 mm2 of the placental parenchyma. Gestational age, birth weight and the following characteristics of the mother were also recorded: pre-pregnancy body mass index, weight gain during pregnancy and hemoglobin concentrations. Birth weight and the gestational age were correlated with PMI (r = .54 and r = .44, respectively; p < .01). Pesticide exposure was associated with a higher PMI (beta = 7.38, p = .01) after adjusting by variables related to placental maturity. In conclusion, the results suggest a relationship between prenatal exposure to pesticides and placental maturity and may potentially affect the nutrient transport from the mother to the fetus.

Từ khóa


Tài liệu tham khảo

10.1016/S0015-0282(98)00253-2

10.1590/S1020-49892003000800004

10.1016/S1383-5742(03)00015-2

10.1177/1933719108322436

10.1016/j.envres.2008.07.014

10.1289/ehp.7894

10.1016/S1047-2797(02)00424-6

10.1289/ehp.6414

Sesline DH, Jackson RJ The effect of the prenatal exposure to pesticides. In: Needleman HLBD (ed.) Prenatal exposure to toxicants. Baltimore: Johns Hop-kins, 1994, p.223—248.

Gupta RC Environmental agents and placental toxicity: anticholinesterases and other insecticides. In: Sastry BV (ed.) Placental toxicology. Tennessee: CRC Press, Inc, 1995, p.257 —278.

10.1016/0002-9378(91)90567-B

Janowiak Z., 1992, Zentralbl Gynakol, 114, 292

Benjaminov O., 1992, Vet Hum Toxicol, 34, 10

Srivastava MK, Raizada RB. Development effect of technical dimethoate in rats: maternal and fetal toxicity evaluation. Indian J Exp Biol 1996; 34: 329—333. 15. Wessler I, Kilbinger H, Bittinger F, Unger R, Kirkpatrick CJ. The non-neuronal cholinergic system in humans: expression, function and pathophysiology. Life Sci 2003; 72: 2055—2061.

Lotti M. Organophosphorus compounds. In: Spencer P , Schaumburg H (ed.) Experimental and clinical neurotoxicology. New York: Oxford University Press Inc, 2000, p.898—925.

10.1016/S0006-2952(97)00017-8

Lewis SH, Benirschke K. Overwiew of the placental pathology and justification for examination of the placenta. In: Lewis SH, Perrin E (eds.). Pathology of the placenta . Philadelphia: Churchill Livingstone , 1991, p.1—26.

10.1016/j.humpath.2005.07.021

10.1111/j.1471-0528.2006.00882.x

10.1159/000293516

Murthy NV, 1977, Indian J Med Res, 65, 523

Sastry BV, 1976, Biochem Pharmacol, 25, 425, 10.1016/0006-2952(76)90345-2

10.1007/BF00931399

10.1007/978-1-4757-4199-5_7

Levario-Carrillo M., 2002, Rev Bras Toxicol, 15, 79

White FMM, 1988, CMAJ, 138, 117

Lagunes-Tejeda A., 1994, Combate químico de plagas agrícolas en México. Colegio de Postgraduados en Ciencias Agrícolas. Consejo Nacional Consultivo Fitosanitario

10.1016/j.chemosphere.2003.11.027

10.1016/0006-2952(61)90145-9

Centro panamericano de ecología humana y salud: Paquete espectofotométrico para medir la actividad de la colinesterasa. Metepec/México, Organización mundial de la salud, 1986, p.1—19.

Benirschke K. , Kaufmann P. Classification of villus maldevelopment . In: Benirschke K, Kaufmann P (eds.) Pathology of the human placenta . New York: Springer, 2000, p.449—450.

Popek EJ Normal anatomy and histology of the placenta. In: Lewis SH, Perrin E (eds.) Pathology of the placenta. Philadelphia: Churchill Livingstone, 1991, p.49—88.

Fajardo-Gutierrez A., 1991, Its definition, evaluation and interpretation. Bol Med Hosp Infant Mex, 48, 367

Prieto L., 1998, Med Clin (Barc), 110, 142

10.1111/j.0001-6349.2005.00563.x

10.1016/S0301-2115(00)00423-1

10.1016/S0378-3782(02)00118-4

10.1136/bmj.304.6833.1052-b

10.1620/tjem.167.247

10.1177/0960327108091863

10.1016/j.fertnstert.2008.01.065

10.1289/ehp.6789

10.1016/j.envres.2008.09.004

10.1016/S0022-3476(78)80621-0

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Human and Experimental Toxicology

Tập 28 Số 8

451-459

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