Toxicokinetics of Paraquat in Humans

Human and Experimental Toxicology - Tập 9 Số 1 - Trang 5-12 - 1990
Pascal Houzé1, Frédéric J. Baud2, Richard Mouy3, C Bismuth2, R Bourdon1, J M Scherrmann1
1Laboratoire de Toxicologie et INSERM U26, Hopital F. Widal, 200 rue du Faubourg Saint-Denis, 75010 Paris
2Clinique Toxicologique Paris V, Hôpital F. Widal, 200 rue du Faubourg Saint-Denis, 75010 Paris
3Service de Réanimation Pédiatrique, Hôpital Necker, 149 rue de Sèvres, 75015 Paris, France

Tóm tắt

1 The toxicokinetics of paraquat were studied in 18 cases of acute human poisoning using a specific radioimmunoassay. Plasma paraquat concentration exhibited a mean distribution half-life ( t½ α) of 5 h and a mean elimination half-life ( t½ β) of 84 h. Cardiovascular collapse supervened early during the course of the intoxication and was associated with the distribution phase. Death related to pulmonary fibrosis occurred late and was associated with the elimination phase.

2 Pharmacokinetic analysis of urine paraquat excretion confirmed the biphasic decline of paraquat. Moreover, renal paraquat and creatinine clearances were not correlated but renal paraquat clearance was never higher than the renal creatinine clearance.

3 Tissue paraquat distribution was ubiquitous with an apparent volume of distribution ranging from 1.2 to 1.6 l/kg. Muscle could represent an important reservoir explaining the long persistence of paraquat in plasma and urine for several weeks or months after poisoning.

Từ khóa


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Human and Experimental Toxicology

Tập 9 Số 1

5-12

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