Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination

Human and Experimental Toxicology - Tập 25 Số 3 - Trang 111-118 - 2006
Sheikh Tasduq Abdullah1, Kuldip Singh, Naresh K. Satti, Damodar Gupta, K. A. Suri1, R.K. Johri1
1Division of Pharmacology and Natural Products Chemistry, Regional Research Laboratory, (CSIR), Canal Road, Jammu–Tawi 180 001, India

Tóm tắt

Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.

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Tài liệu tham khảo

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Human and Experimental Toxicology

Tập 25 Số 3

111-118

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