Genes
SCOPUS (2010-2023)SCIE-ISI
2073-4425
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
Genetics (clinical)Genetics
Các bài báo tiêu biểu
MYC Deregulation in Primary Human CancersMYC regulates a complex biological program by transcriptionally activating and repressing its numerous target genes. As such, MYC is a master regulator of many processes, including cell cycle entry, ribosome biogenesis, and metabolism. In cancer, the activity of the MYC transcriptional network is frequently deregulated, contributing to the initiation and maintenance of disease. Deregulatio... ... hiện toàn bộ
Tập 8 Số 6 - Trang 151
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain FunctionDNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole... ... hiện toàn bộ
Tập 8 Số 6 - Trang 148
Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic ConsiderationsBeing the most common musculoskeletal progressive condition, osteoarthritis is an interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease... ... hiện toàn bộ
Tập 11 Số 8 - Trang 854
Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project SuccessCharcot-Marie-Tooth (CMT) neuropathies comprise a group of monogenic disorders affecting the peripheral nervous system. CMT is characterized by a clinically and genetically heterogeneous group of neuropathies, involving all types of Mendelian inheritance patterns. Over 1,000 different mutations have been discovered in 80 disease-associated genes. Genetic research of CMT has pioneered the ... ... hiện toàn bộ
Tập 5 Số 1 - Trang 13-32
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in InflammationMitogen-activated protein kinase (MAPK) pathways are implicated in several cellular processes including proliferation, differentiation, apoptosis, cell survival, cell motility, metabolism, stress response and inflammation. MAPK pathways transmit and convert a plethora of extracellular signals by three consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK kinase, and a M... ... hiện toàn bộ
Tập 4 Số 2 - Trang 101-133
Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-AnalysisDietary alteration of the gut microbiome is an important target in the treatment of obesity. Animal and human studies have shown bidirectional weight modulation based on the probiotic formulation used. In this study, we systematically reviewed the literature and performed a meta-analysis to assess the impact of prebiotics, probiotics and synbiotics on body weight, body mass index (BMI) and... ... hiện toàn bộ
Tập 9 Số 3 - Trang 167
Blueprints for Biosensors: Design, Limitations, and ApplicationsBiosensors are enabling major advances in the field of analytics that are both facilitating and being facilitated by advances in synthetic biology. The ability of biosensors to rapidly and specifically detect a wide range of molecules makes them highly relevant to a range of industrial, medical, ecological, and scientific applications. Approaches to biosensor design are as diverse as their... ... hiện toàn bộ
Tập 9 Số 8 - Trang 375
Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic ChipsAir quality depends on the various gases and particles present in it. Both natural phenomena and human activities affect the cleanliness of air. In the last decade, many countries experienced an unprecedented industrial growth, resulting in changing air quality values, and correspondingly, affecting our life quality. Air quality can be accessed by employing microchips that qualitatively an... ... hiện toàn bộ
Tập 8 Số 10 - Trang 244
Genome-Wide Identification and Structural Analysis of bZIP Transcription Factor Genes in Brassica napusThe basic region/leucine zipper motif (bZIP) transcription factor family is one of the largest families of transcriptional regulators in plants. bZIP genes have been systematically characterized in some plants, but not in rapeseed (Brassica napus). In this study, we identified 247 BnbZIP genes in the rapeseed genome, which we classified into 10 subfamilies based on phylogenetic analysis of... ... hiện toàn bộ
Tập 8 Số 10 - Trang 288
At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric SequencesTandem DNA repeats derived from the ancestral (TTAGGG)n run were first detected at chromosome ends of the majority of living organisms, hence the name telomeric DNA repeats. Subsequently, it has become clear that telomeric motifs are also present within chromosomes, and they were suitably called interstitial telomeric sequences (ITSs). It is well known that telomeric DNA repeats play a key... ... hiện toàn bộ
Tập 10 Số 2 - Trang 118