Genes
SCOPUS (2010-2025)SCIE-ISI
2073-4425
Thụy Sĩ
Cơ quản chủ quản: MDPI , Multidisciplinary Digital Publishing Institute (MDPI)
Lĩnh vực:
Genetics (clinical)Genetics
Phân tích ảnh hưởng
Các bài báo tiêu biểu
MYC Deregulation in Primary Human Cancers
Tập 8 Số 6 - Trang 151
MYC regulates a complex biological program by transcriptionally activating and
repressing its numerous target genes. As such, MYC is a master regulator of many
processes, including cell cycle entry, ribosome biogenesis, and metabolism. In
cancer, the activity of the MYC transcriptional network is frequently
deregulated, contributing to the initiation and maintenance of disease.
Deregulation often ...
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
Tập 8 Số 6 - Trang 148
DNA methylation is a major epigenetic mark with important roles in genetic
regulation. Methylated cytosines are found primarily at CpG dinucleotides, but
are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of
CpG and non-CpG methylation include gene silencing or activation depending on
the methylated regions. CpG and non-CpG methylation are found throughout the
whole genome,...
Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations
Tập 11 Số 8 - Trang 854
Being the most common musculoskeletal progressive condition, osteoarthritis is
an interesting target for research. It is estimated that the prevalence of knee
osteoarthritis (OA) among adults 60 years of age or older is approximately 10%
in men and 13% in women, making knee OA one of the leading causes of disability
in elderly population. Today, we know that osteoarthritis is not a disease
charact...
Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success
Tập 5 Số 1 - Trang 13-32
Charcot-Marie-Tooth (CMT) neuropathies comprise a group of monogenic disorders
affecting the peripheral nervous system. CMT is characterized by a clinically
and genetically heterogeneous group of neuropathies, involving all types of
Mendelian inheritance patterns. Over 1,000 different mutations have been
discovered in 80 disease-associated genes. Genetic research of CMT has pioneered
the discovery...
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation
Tập 4 Số 2 - Trang 101-133
Mitogen-activated protein kinase (MAPK) pathways are implicated in several
cellular processes including proliferation, differentiation, apoptosis, cell
survival, cell motility, metabolism, stress response and inflammation. MAPK
pathways transmit and convert a plethora of extracellular signals by three
consecutive phosphorylation events involving a MAPK kinase kinase, a MAPK
kinase, and a MAPK. In ...
Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis
Tập 9 Số 3 - Trang 167
Dietary alteration of the gut microbiome is an important target in the treatment
of obesity. Animal and human studies have shown bidirectional weight modulation
based on the probiotic formulation used. In this study, we systematically
reviewed the literature and performed a meta-analysis to assess the impact of
prebiotics, probiotics and synbiotics on body weight, body mass index (BMI) and
fat mas...
Blueprints for Biosensors: Design, Limitations, and Applications
Tập 9 Số 8 - Trang 375
Biosensors are enabling major advances in the field of analytics that are both
facilitating and being facilitated by advances in synthetic biology. The ability
of biosensors to rapidly and specifically detect a wide range of molecules makes
them highly relevant to a range of industrial, medical, ecological, and
scientific applications. Approaches to biosensor design are as diverse as their
applica...
Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips
Tập 8 Số 10 - Trang 244
Air quality depends on the various gases and particles present in it. Both
natural phenomena and human activities affect the cleanliness of air. In the
last decade, many countries experienced an unprecedented industrial growth,
resulting in changing air quality values, and correspondingly, affecting our
life quality. Air quality can be accessed by employing microchips that
qualitatively and quanti...
At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences
Tập 10 Số 2 - Trang 118
Tandem DNA repeats derived from the ancestral (TTAGGG)n run were first detected
at chromosome ends of the majority of living organisms, hence the name telomeric
DNA repeats. Subsequently, it has become clear that telomeric motifs are also
present within chromosomes, and they were suitably called interstitial telomeric
sequences (ITSs). It is well known that telomeric DNA repeats play a key role in...
Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis
Tập 9 Số 5 - Trang 263
Soil-dwelling bacteria collectively referred to as rhizobia synthesize and
perceive N-acyl-homoserine lactone (AHL) signals to regulate gene expression in
a population density-dependent manner. AHL-mediated signaling in these bacteria
regulates several functions which are important for the establishment of
nitrogen-fixing symbiosis with legume plants. Moreover, rhizobial AHL act as
interkingdom si...