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Transcriptome Profiling and Molecular Therapeutic Advances in Cystic Fibrosis: Recent Insights
Genes - Tập 10 Số 3 - Trang 180
Justin E. Ideozu, Xi Zhang, Susanna A. McColley, Hara Levy
In cystic fibrosis (CF), mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene disrupt the capacity of the encoded protein to function as a channel to transport chloride ions and water across cell membranes. The consequences are deleterious, system-wide, and immensely variable, even among patients with the same CFTR genotype. This underscores the need to characte...... hiện toàn bộ
Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips
Genes - Tập 8 Số 10 - Trang 244
Frank Schulze, Xinghua Gao, Darius Viržonis, Samar Damiati, Marlon R. Schneider, Rimantas Kodzius
Air quality depends on the various gases and particles present in it. Both natural phenomena and human activities affect the cleanliness of air. In the last decade, many countries experienced an unprecedented industrial growth, resulting in changing air quality values, and correspondingly, affecting our life quality. Air quality can be accessed by employing microchips that qualitatively an...... hiện toàn bộ
Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide
Genes - Tập 12 Số 8 - Trang 1285
Magdalena Wysocka, Roxana Zamudio, Marco R. Oggioni, Justyna Gołębiewska, Marek Bronk, Beata Krawczyk
In recent years, there has been an observed increase in infections caused by carbapenem-resistant Klebsiella pneumonia (Kp) strains. The aim of this study was the phenotypic and genotypic analysis of eight K. pneumoniae NDM (Kp NDM) isolates, recovered in Poland during the years 2016 and 2018 from seven patients with urinary tract infections (UTIs), asymptomatic bacteriuria (ABU), or colon...... hiện toàn bộ
Comparative Transcriptome Analysis of Gene Expression Patterns in Tomato Under Dynamic Light Conditions
Genes - Tập 10 Số 9 - Trang 662
Juanjuan Ding, Jiantao Zhao, Tonghua Pan, Linjie Xi, Jing Zhang, Zhirong Zou
Plants grown under highly variable natural light regimes differ strongly from plants grown under constant light (CL) regimes. Plant phenotype and adaptation responses are important for plant biomass and fitness. However, the underlying regulatory mechanisms are still poorly understood, particularly from a transcriptional perspective. To investigate the influence of different light regimes ...... hiện toàn bộ
Genetics of Charcot-Marie-Tooth (CMT) Disease within the Frame of the Human Genome Project Success
Genes - Tập 5 Số 1 - Trang 13-32
Vincent Timmerman, Alleene V. Strickland, Stephan Züchner
Charcot-Marie-Tooth (CMT) neuropathies comprise a group of monogenic disorders affecting the peripheral nervous system. CMT is characterized by a clinically and genetically heterogeneous group of neuropathies, involving all types of Mendelian inheritance patterns. Over 1,000 different mutations have been discovered in 80 disease-associated genes. Genetic research of CMT has pioneered the ...... hiện toàn bộ
Regulation Mediated by N-Acyl Homoserine Lactone Quorum Sensing Signals in the Rhizobium-Legume Symbiosis
Genes - Tập 9 Số 5 - Trang 263
Nieves Calatrava‐Morales, Matthew McIntosh, Marı́a J. Soto
Soil-dwelling bacteria collectively referred to as rhizobia synthesize and perceive N-acyl-homoserine lactone (AHL) signals to regulate gene expression in a population density-dependent manner. AHL-mediated signaling in these bacteria regulates several functions which are important for the establishment of nitrogen-fixing symbiosis with legume plants. Moreover, rhizobial AHL act as interki...... hiện toàn bộ
Quorum Sensing and Quorum Quenching in Agrobacterium: A “Go/No Go System”?
Genes - Tập 9 Số 4 - Trang 210
Yves Dessaux, Denis Faure
The pathogen Agrobacterium induces gall formation on a wide range of dicotyledonous plants. In this bacteria, most pathogenicity determinants are borne on the tumour inducing (Ti) plasmid. The conjugative transfer of this plasmid between agrobacteria is regulated by quorum sensing (QS). However, processes involved in the disturbance of QS also occur in this bacteria under the molecular for...... hiện toàn bộ
Genome-Wide Identification and Structural Analysis of bZIP Transcription Factor Genes in Brassica napus
Genes - Tập 8 Số 10 - Trang 288
Yan Zhou, Daixiang Xu, Ledong Jia, Xiaohu Huang, Guoqiang Ma, Shuxian Wang, Meichen Zhu, Aoxiang Zhang, Mingwei Guan, Kun Lu, Xinfu Xu, Rui Wang, Jiana Li, Cunmin Qu
The basic region/leucine zipper motif (bZIP) transcription factor family is one of the largest families of transcriptional regulators in plants. bZIP genes have been systematically characterized in some plants, but not in rapeseed (Brassica napus). In this study, we identified 247 BnbZIP genes in the rapeseed genome, which we classified into 10 subfamilies based on phylogenetic analysis of...... hiện toàn bộ
CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
Genes - Tập 8 Số 6 - Trang 148
Hyun Gyung Jang, Woo Yong Shin, Jeong‐Bong Lee, Jeong Tae
DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole...... hiện toàn bộ
A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions
Genes - Tập 10 Số 2 - Trang 140
Caren J. Blacker, Mark A. Frye, Éva Morava, Tamás Kozicz, Erminio Costa
Post-traumatic stress disorder (PTSD) is an acquired psychiatric disorder with functionally impairing physiological and psychological symptoms following a traumatic exposure. Genetic, epigenetic, and environmental factors act together to determine both an individual’s susceptibility to PTSD and its clinical phenotype. In this literature review, we briefly review the candidate genes that ha...... hiện toàn bộ
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