Environmental and Molecular Mutagenesis
SCIE-ISI SCOPUS (1987-2023)
1098-2280
0893-6692
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
EpidemiologyGenetics (clinical)Health, Toxicology and Mutagenesis
Các bài báo tiêu biểu
Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Tập 10 Số S10 - Trang 1-35 - 1987
Meat‐related mutagens/carcinogens in the etiology of colorectal cancerAbstract Diets containing substantial amounts of red or preserved meats may increase the risk of various cancers, including colorectal cancer. This association may be due to a combination of factors such as the content of fat, protein, iron, and/or meat preparation (e.g., cooking or preserving methods). Red meat may be associated with colorectal cancer by contributi... ... hiện toàn bộ
Tập 44 Số 1 - Trang 44-55 - 2004
Induction of oxidative stress by bisphenol A and its pleiotropic effectsBisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exp... ... hiện toàn bộ
Tập 58 Số 2 - Trang 60-71 - 2017
Human population studies with cytogenetic biomarkers: Review of the literature and future prospectivesAbstract Cytogenetic biomarkers are by far the most frequently used endpoints in human population studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early predictors of cancer risk have contributed to this success. In this article, we present an overview of the last 25 years of population studies with cytogenetic biomarkers, desc... ... hiện toàn bộ
Tập 45 Số 2-3 - Trang 258-270 - 2005
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vectorAbstract A short term, in vivo mutagenesis assay has been developed utilizing a lacl target gene contained within a lambda ZAP shuttle vector which has been incorporated into transgenic mice. Following chemical exposure, the target gene was recovered from mouse genomic DNA by mixing the DNA with in vitro lambda phage packaging extract. Mut... ... hiện toàn bộ
Tập 18 Số 4 - Trang 316-321 - 1991
A brief overview of mechanisms of mitochondrial toxicity from NRTIsAbstract Nucleoside reverse transcriptase inhibitors (NRTIs) in combinations with other antiretrovirals (highly active antiretroviral therapy, HAART) are the cornerstones of AIDS therapy, turning HIV infection into a manageable clinical entity. Despite the initial positive impact of NRTIs, therapeutic experience revealed serious side effects that appeared to origina... ... hiện toàn bộ
Tập 48 Số 3-4 - Trang 166-172 - 2007
Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicalsAbstract The National Toxicology Program has undertaken a study to assess the ability of four genetic toxicology assays to predict the carcinogenicity of chemicals in 2‐year rodent studies [Tennant et al.: Science 236:933–941, 1987]. Two of the assays, used for evaluating in vitro cytogenetic damage, were the SCE and chromosome aberration ... ... hiện toàn bộ
Tập 14 Số 3 - Trang 165-187 - 1989
Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivoAbstract MutaMouse is a transgenic mouse engineered to detect mutations in vivo in any tissue of choice by using simple laboratory methods. The target is a bacterial lacZ gene incorporated via lambda phage into the genome of each mouse cell such that a concatamer of approximately 40 copies exists at a single site on both chromosomes of a h... ... hiện toàn bộ
Tập 18 Số 4 - Trang 308-315 - 1991
Di‐(2‐ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitroBisphenol‐A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds widely used in commercial plastic products. Previous studies have shown that exposure to such compounds have adverse effects on various aspects of mammalian reproduction including folliculogenesis. The objective of this study was to examine the effects of BPA and DEHP exposure on primordial follicle formation. We ... ... hiện toàn bộ
Tập 55 Số 4 - Trang 343-353 - 2014
Conditions for detecting the mutagenicity of divalent metals in Salmonella typhimuriumAbstract The mutagenesis of metals in bacteria, as reported in the literature, can best be described as inconsistent. We report that cobalt chloride (Co++ ), ferrous sulfate (Fe++ ), manganese sulfate (Mn++ ), cadmium chloride (Cd++ ), and zinc chloride (Zn++ ) could ... ... hiện toàn bộ
Tập 19 Số 2 - Trang 139-146 - 1992