Environmental and Molecular Mutagenesis
SCIE-ISI SCOPUS (1987-2025)
1098-2280
0893-6692
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
EpidemiologyGenetics (clinical)Health, Toxicology and Mutagenesis
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Các bài báo tiêu biểu
Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Tập 10 Số S10 - Trang 1-35 - 1987
Meat‐related mutagens/carcinogens in the etiology of colorectal cancer
Tập 44 Số 1 - Trang 44-55 - 2004
AbstractDiets containing substantial amounts of red or preserved meats may
increase the risk of various cancers, including colorectal cancer. This
association may be due to a combination of factors such as the content of fat,
protein, iron, and/or meat preparation (e.g., cooking or preserving methods).
Red meat may be associated with colorectal cancer by contributing to N‐nitroso
compound (NOC) ex...
Induction of oxidative stress by bisphenol A and its pleiotropic effects
Tập 58 Số 2 - Trang 60-71 - 2017
Bisphenol A (BPA) has become a target of intense public scrutiny since concerns
about its association with human diseases such as obesity, diabetes,
reproductive disorders, and cancer have emerged. BPA is a highly prevalent
chemical in consumer products, and human exposure is thought to be ubiquitous.
Numerous studies have demonstrated its endocrine disrupting properties and
attributed exposure wi...
Human population studies with cytogenetic biomarkers: Review of the literature and future prospectives
Tập 45 Số 2-3 - Trang 258-270 - 2005
AbstractCytogenetic biomarkers are by far the most frequently used endpoints in
human population studies. Their sensitivity for measuring exposure to genotoxic
agents and their role as early predictors of cancer risk have contributed to
this success. In this article, we present an overview of the last 25 years of
population studies with cytogenetic biomarkers, describing the evolution of this
rese...
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector
Tập 18 Số 4 - Trang 316-321 - 1991
AbstractA short term, in vivo mutagenesis assay has been developed utilizing a
lacl target gene contained within a lambda ZAP shuttle vector which has been
incorporated into transgenic mice. Following chemical exposure, the target gene
was recovered from mouse genomic DNA by mixing the DNA with in vitro lambda
phage packaging extract. Mutations within the lacl target were identified by
infecting h...
A brief overview of mechanisms of mitochondrial toxicity from NRTIs
Tập 48 Số 3-4 - Trang 166-172 - 2007
AbstractNucleoside reverse transcriptase inhibitors (NRTIs) in combinations with
other antiretrovirals (highly active antiretroviral therapy, HAART) are the
cornerstones of AIDS therapy, turning HIV infection into a manageable clinical
entity. Despite the initial positive impact of NRTIs, therapeutic experience
revealed serious side effects that appeared to originate in the mitochondria and
which ...
Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals
Tập 14 Số 3 - Trang 165-187 - 1989
AbstractThe National Toxicology Program has undertaken a study to assess the
ability of four genetic toxicology assays to predict the carcinogenicity of
chemicals in 2‐year rodent studies [Tennant et al.: Science 236:933–941, 1987].
Two of the assays, used for evaluating in vitro cytogenetic damage, were the SCE
and chromosome aberration assays in Chinese hamster ovary cells. The results and
data ...
Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo
Tập 18 Số 4 - Trang 308-315 - 1991
AbstractMutaMouse is a transgenic mouse engineered to detect mutations in vivo
in any tissue of choice by using simple laboratory methods. The target is a
bacterial lacZ gene incorporated via lambda phage into the genome of each mouse
cell such that a concatamer of approximately 40 copies exists at a single site
on both chromosomes of a homologous pair. In order to assess the potential
usefulness ...
Di‐(2‐ethylhexyl) phthalate and bisphenol A exposure impairs mouse primordial follicle assembly in vitro
Tập 55 Số 4 - Trang 343-353 - 2014
Bisphenol‐A (BPA) and diethylhexyl phthalate (DEHP) are estrogenic compounds
widely used in commercial plastic products. Previous studies have shown that
exposure to such compounds have adverse effects on various aspects of mammalian
reproduction including folliculogenesis. The objective of this study was to
examine the effects of BPA and DEHP exposure on primordial follicle formation.
We found th...
Chromosome aberration and sister chromatid exchange tests in chinese hamster ovary cells in vitro: II. Results with 20 chemicals
Tập 13 Số 1 - Trang 60-94 - 1989
AbstractTwenty chemicals were tested for their ability to induce sister
chromatid exchanges (SCEs) and chromosomal aberrations (ABs) in cultured Chinese
hamster ovary cells (CHO). These chemicals were tested with and without an added
metabolic activation system (rat liver S9 fraction). Four chemicals were
negative in both assays, 1 induced ABs only, and 15 were positive for SCEs; 6 of
these 15 als...