Environmental and Molecular Mutagenesis

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Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by‐products
Environmental and Molecular Mutagenesis - Tập 54 Số 8 - Trang 629-637 - 2013
Azra Dad, Clara H. Jeong, Justin A. Pals, Elizabeth D. Wagner, Michael J. Plewa
Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by‐products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA‐mediated inhibition of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This model predicts that GAPDH inhibition by the monoHAAs will lead to a severe ...... hiện toàn bộ
Analysis of Salmonella typhimurium hisD3052 revertants: The use of oligodeoxyribonucleotide colony hybridization, PCR, and direct sequencing in mutational analysis
Environmental and Molecular Mutagenesis - Tập 18 Số 4 - Trang 224-230 - 1991
Eugene Kupchella, Thomas A. Cebula
AbstractA rapid method for determining the DNA sequences of Salmonella typhimurium hisD3052 revertants is presented. DNA colony hybridization was used to analyze revertants previously studied by Isono and Yourno [Proc Natl Acad Sci USA 71:1612–1617, 1974]. Synthetic oligodeoxy‐ribonucleotide probes (18‐mers) were able to distinguish seque...... hiện toàn bộ
Mutations induced by (−)‐anti‐11R,12S‐dihydrodiol 13S,14R‐epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells
Environmental and Molecular Mutagenesis - Tập 41 Số 2 - Trang 131-139 - 2003
Brinda Mahadevan, Wan‐Mohaiza Dashwood, Andreas Luch, Arta Pecaj, Johannes Doehmer, Albrecht Seidel, Cliff Pereira, William M. Baird
AbstractThe polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) is an exceptionally potent carcinogen. Its direct DNA‐reactive metabolite, the fjord region (−)‐anti‐11R,12S‐dihydrodiol 13S,14... hiện toàn bộ
Cytogenetic analyses of mice exposed to dichloromethane
Environmental and Molecular Mutagenesis - Tập 15 Số 4 - Trang 221-228 - 1990
James W. Allen, Andrew D. Kligerman, James A. Campbell, Barbara Westbrook‐Collins, Gregory L. Erexson, Frank W. Kari, Errol Zeiger
AbstractChromosome damage was studied in female B6C3F1 mice exposed to dichloromethane (DCM) by subcutaneous or inhalation treatments. No increase in the frequency of either sister chromatid exchanges (SCEs) or chromosome aberrations (CAs) in bone marrow cells was observed after a single subcutaneous injection of 2,500 or 5,000 mg/kg DCM. Inhalation exposure to DCM...... hiện toàn bộ
DNA damage in Pakistani agricultural workers exposed to mixture of pesticides
Environmental and Molecular Mutagenesis - Tập 50 Số 1 - Trang 37-45 - 2009
Javed A. Bhalli, Tayyaba Ali, Muhammad Rafiq Asi, Zafar M. Khalid, Marcello Ceppi, Qaiser M. Khan
AbstractA cross‐sectional study was designed to determine whether occupational exposure to a complex mixture of pesticides results in a significant increase of DNA damage in farmers chronically exposed to pesticides in open fields. Leukocytes from 47 agriculture workers exposed to pesticides and 50 controls were evaluated with comet assay. Workers recruitment was b...... hiện toàn bộ
Relative sensitivity of fish and mammalian cells to sodium arsenate and arsenite as determined by alkaline single‐cell gel electrophoresis and cytokinesis‐block micronucleus assay
Environmental and Molecular Mutagenesis - Tập 44 Số 1 - Trang 83-89 - 2004
Sheikh Raisuddin, Awadhesh N. Jha
AbstractTo protect human and ecosystem health, it is necessary to develop sensitive assays and to identify responsive cells and species (and their life stages). In this study, the relative genotoxicity of two inorganic arsenicals: trivalent sodium arsenite (As3+) and pentavalent sodium arsenate (As5+), was evaluated in two ...... hiện toàn bộ
Bone marrow micronucleus assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies
Environmental and Molecular Mutagenesis - Tập 23 Số 4 - Trang 239-273 - 1994
Michael F. Salamone, Kathleen H. Mavournin
AbstractWe have examined published negative control data from 581 papers on micronucleated bone marrow polychromatic erythrocytes (mnPCE) for differences in mean frequency and the frequency distribution profile among the mouse stocks used with the bone marrow micronucleus assay. For the 55 mouse stocks with published micronucleus assay data, the overall mean freque...... hiện toàn bộ
Increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males
Environmental and Molecular Mutagenesis - Tập 50 Số 6 - Trang 489-501 - 2009
Jing Wu, Carolyn Salisbury, Robin D. Graham, Graham Lyons, Michael Fenech
AbstractIncreased intake of selenium (Se) may reduce the risk of degenerative diseases including cancer but excessive intake may be toxic. Wheat is a major source of dietary Se in humans. However, the effect of Se from wheat that is agronomically biofortified with Se on biomarkers of human health status is unknown. This study aimed to investigate whether improving ...... hiện toàn bộ
Conditions for detecting the mutagenicity of divalent metals in Salmonella typhimurium
Environmental and Molecular Mutagenesis - Tập 19 Số 2 - Trang 139-146 - 1992
Dennis A. Pagano, Errol Zeiger
AbstractThe mutagenesis of metals in bacteria, as reported in the literature, can best be described as inconsistent. We report that cobalt chloride (Co++), ferrous sulfate (Fe++), manganese sulfate (Mn++), cadmium chloride (Cd++), and zinc chloride (Zn++) could ...... hiện toàn bộ
Use of the microscreen phage‐induction assay to assess the genotoxicity of 14 hazardous industrial wastes
Environmental and Molecular Mutagenesis - Tập 11 Số 1 - Trang 13-29 - 1988
Virginia S. Houk, David M. DeMarini
AbstractThe Microscreen phage‐induction assay, which quantitatively measures the induction of prophage λ in Escherichia coli WP2s(λ), was used to test 14 crude (unfractionated) hazardous industrial waste samples for genotoxic activity in the presence and absence of metabolic activation. Eleven of the 14 wastes induced...... hiện toàn bộ
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