Environmental and Molecular Mutagenesis

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Genotoxic effects of p‐aminophenol in chinese hamster ovary and mouse lymphoma cells: Results of a multiple endpoint test
Environmental and Molecular Mutagenesis - Tập 26 Số 2 - Trang 163-170 - 1995
Jenness B. Majeska, Henry E. Holden
Abstractp‐Aminophenol (PAP), a metabolite of aniline and acetaminophen, has been reported to be mutagenic in the L5178Y mouse lymphoma assay, but not in the CHO/HGPRT assay. In the present study, the effects of PAP in these two cells lines were examined to determine if the difference in activity is related to an intrinsic difference in th...... hiện toàn bộ
Increased consumption of wheat biofortified with selenium does not modify biomarkers of cancer risk, oxidative stress, or immune function in healthy Australian males
Environmental and Molecular Mutagenesis - Tập 50 Số 6 - Trang 489-501 - 2009
Jing Wu, Carolyn Salisbury, Robin D. Graham, Graham Lyons, Michael Fenech
AbstractIncreased intake of selenium (Se) may reduce the risk of degenerative diseases including cancer but excessive intake may be toxic. Wheat is a major source of dietary Se in humans. However, the effect of Se from wheat that is agronomically biofortified with Se on biomarkers of human health status is unknown. This study aimed to investigate whether improving ...... hiện toàn bộ
Chromosome aberration and sister chromatid exchange tests in chinese hamster ovary cells in vitro: II. Results with 20 chemicals
Environmental and Molecular Mutagenesis - Tập 13 Số 1 - Trang 60-94 - 1989
Kenneth S. Loveday, M. H. Lugo, Michael A. Resnick, Beth Anderson, Errol Zeiger
AbstractTwenty chemicals were tested for their ability to induce sister chromatid exchanges (SCEs) and chromosomal aberrations (ABs) in cultured Chinese hamster ovary cells (CHO). These chemicals were tested with and without an added metabolic activation system (rat liver S9 fraction). Four chemicals were negative in both assays, 1 induced ABs only, and 15 were pos...... hiện toàn bộ
Cytogenetic analyses of mice exposed to dichloromethane
Environmental and Molecular Mutagenesis - Tập 15 Số 4 - Trang 221-228 - 1990
James W. Allen, Andrew D. Kligerman, James A. Campbell, Barbara Westbrook‐Collins, Gregory L. Erexson, Frank W. Kari, Errol Zeiger
AbstractChromosome damage was studied in female B6C3F1 mice exposed to dichloromethane (DCM) by subcutaneous or inhalation treatments. No increase in the frequency of either sister chromatid exchanges (SCEs) or chromosome aberrations (CAs) in bone marrow cells was observed after a single subcutaneous injection of 2,500 or 5,000 mg/kg DCM. Inhalation exposure to DCM...... hiện toàn bộ
Chromosome aberrations and sister chromatid exchanges in chinese hamster ovary cells: Evaluations of 108 chemicals
Environmental and Molecular Mutagenesis - Tập 10 Số S10 - Trang 1-35 - 1987
Sheila M. Galloway, Michael J. Armstrong, Rine Christopher Reuben, S M Colman, B. M. Brown, Christopher P. Cannon, Arthur D. Bloom, Frances Nakamura, Muna Abdul Fattah Ahmed, Soledad Duk, J. Y. Rimpo, Barry H. Margolin, Michael A. Resnick, B. Anderson, Errol Zeiger
Induction of oxidative stress by bisphenol A and its pleiotropic effects
Environmental and Molecular Mutagenesis - Tập 58 Số 2 - Trang 60-71 - 2017
Natalie R. Gassman
Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exp...... hiện toàn bộ
Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals
Environmental and Molecular Mutagenesis - Tập 14 Số 3 - Trang 165-187 - 1989
James L. Ivett, B. M. Brown, Catherine S. Rodgers, Beth Anderson, Michael A. Resnick, Errol Zeiger
AbstractThe National Toxicology Program has undertaken a study to assess the ability of four genetic toxicology assays to predict the carcinogenicity of chemicals in 2‐year rodent studies [Tennant et al.: Science 236:933–941, 1987]. Two of the assays, used for evaluating in vitro cytogenetic damage, were the SCE and chromosome aberration ...... hiện toàn bộ
Identification of human cell responses to hexavalent chromium
Environmental and Molecular Mutagenesis - Tập 48 Số 8 - Trang 650-657 - 2007
Igor M. Gavin, Bruce S. Gillis, Zarema Arbieva, Bellur S. Prabhakar
AbstractHexavalent chromium [Cr(VI)] is a recognized environmental toxin with ubiquitous distribution in industrialized societies. Its concentration in ambient air derives from several sources including but not limited to chemical processes, the burning of fossil fuels and the production of cement. It is a food contaminant because of its deposition into bodies of w...... hiện toàn bộ
Use of the microscreen phage‐induction assay to assess the genotoxicity of 14 hazardous industrial wastes
Environmental and Molecular Mutagenesis - Tập 11 Số 1 - Trang 13-29 - 1988
Virginia S. Houk, David M. DeMarini
AbstractThe Microscreen phage‐induction assay, which quantitatively measures the induction of prophage λ in Escherichia coli WP2s(λ), was used to test 14 crude (unfractionated) hazardous industrial waste samples for genotoxic activity in the presence and absence of metabolic activation. Eleven of the 14 wastes induced...... hiện toàn bộ
Conditions for detecting the mutagenicity of divalent metals in Salmonella typhimurium
Environmental and Molecular Mutagenesis - Tập 19 Số 2 - Trang 139-146 - 1992
Dennis A. Pagano, Errol Zeiger
AbstractThe mutagenesis of metals in bacteria, as reported in the literature, can best be described as inconsistent. We report that cobalt chloride (Co++), ferrous sulfate (Fe++), manganese sulfate (Mn++), cadmium chloride (Cd++), and zinc chloride (Zn++) could ...... hiện toàn bộ
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