Environmental and Molecular Mutagenesis

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Can nongenotoxic carcinogens be detected with the lacl transgenic mouse mutation assay?
Environmental and Molecular Mutagenesis - Tập 21 Số 3 - Trang 209-211 - 1993
Daniela Gunz, S.E. Shephard, Werner K. Lutz
Sources of variability in data from a lacl transgenic mouse mutation assay
Environmental and Molecular Mutagenesis - Tập 23 Số 1 - Trang 17-31 - 1994
Walter W. Piegorsch, Ann‐Marie C. Lockhart, Barry H. Margolin, Kenneth R. Tindall, Nancy J. Gorelick, Jay M. Short, Gregory J. Carr, Elizabeth I. Thompson, Michael D. Shelby
AbstractExperimental features of a transgenic mouse mutation assay based on a lacl target transgene from Escherichia coli are considered in detail. Sources of variability in the experimental protocol that can affect the statistical nature of the observations are examined with the goal of identifying sources of excess variation in the observed mutant fractions. The sources include plate‐to‐plate (w... hiện toàn bộ
Validation studies with Muta™ mouse: A transgenic mouse model for detecting mutations in vivo
Environmental and Molecular Mutagenesis - Tập 18 Số 4 - Trang 308-315 - 1991
B. Myhr
AbstractMutaMouse is a transgenic mouse engineered to detect mutations in vivo in any tissue of choice by using simple laboratory methods. The target is a bacterial lacZ gene incorporated via lambda phage into the genome of each mouse cell such that a concatamer of approximately 40 copies exists at a single site on both chromosomes of a homologous pair. In order to assess the potential usefulness ... hiện toàn bộ
Big blue transgenic mouse lacl mutation analysis
Environmental and Molecular Mutagenesis - Tập 22 Số 3 - Trang 127-129 - 1993
Gary L. Stiegler, Lisa C. Stillwell
Analysis of spontaneous and induced mutations in transgenic mice using a lambda ZAP/lacl shuttle vector
Environmental and Molecular Mutagenesis - Tập 18 Số 4 - Trang 316-321 - 1991
Steven W. Kohler, Gabrielle S. Le Provost, Annabeth Fieck, Patricia L. Kretz, William O. Bullock, Donald L. Putman, Joseph A. Sorge, Jay M. Short
AbstractA short term, in vivo mutagenesis assay has been developed utilizing a lacl target gene contained within a lambda ZAP shuttle vector which has been incorporated into transgenic mice. Following chemical exposure, the target gene was recovered from mouse genomic DNA by mixing the DNA with in vitro lambda phage packaging extract. Mutations within the lacl target were identified by infecting h... hiện toàn bộ
Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects
Environmental and Molecular Mutagenesis - Tập 51 Số 1 - Trang 57-63 - 2010
Özlem Akıncı, Ercan Mıhçı, Şükran Taçoy, Fırat Kardelen, İbrahim Keser, Mutay Aslan
AbstractDown syndrome (DS) occurs when an individual has three, rather than two, copies of the 21st chromosome. Cytosolic superoxide dismutase (SOD‐1) is encoded by a gene on chromosome 21 and thus, SOD‐1 activity is elevated in patients with DS. Forty percent of all cases with DS are associated with congenital heart defects (CHD). Although the contribution of SOD1 to disease phenotype is unknown,... hiện toàn bộ
A brief overview of mechanisms of mitochondrial toxicity from NRTIs
Environmental and Molecular Mutagenesis - Tập 48 Số 3-4 - Trang 166-172 - 2007
James J. Kohler, William Lewis
AbstractNucleoside reverse transcriptase inhibitors (NRTIs) in combinations with other antiretrovirals (highly active antiretroviral therapy, HAART) are the cornerstones of AIDS therapy, turning HIV infection into a manageable clinical entity. Despite the initial positive impact of NRTIs, therapeutic experience revealed serious side effects that appeared to originate in the mitochondria and which ... hiện toàn bộ
Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by‐products
Environmental and Molecular Mutagenesis - Tập 54 Số 8 - Trang 629-637 - 2013
Azra Dad, Clara H. Jeong, Justin A. Pals, Elizabeth D. Wagner, Michael J. Plewa
Monohaloacetic acids (monoHAAs) are a major class of drinking water disinfection by‐products (DBPs) and are cytotoxic, genotoxic, mutagenic, and teratogenic. We propose a model of toxic action based on monoHAA‐mediated inhibition of glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) as a target cytosolic enzyme. This model predicts that GAPDH inhibition by the monoHAAs will lead to a severe reductio... hiện toàn bộ
Analysis of Salmonella typhimurium hisD3052 revertants: The use of oligodeoxyribonucleotide colony hybridization, PCR, and direct sequencing in mutational analysis
Environmental and Molecular Mutagenesis - Tập 18 Số 4 - Trang 224-230 - 1991
Eugene Kupchella, Thomas A. Cebula
AbstractA rapid method for determining the DNA sequences of Salmonella typhimurium hisD3052 revertants is presented. DNA colony hybridization was used to analyze revertants previously studied by Isono and Yourno [Proc Natl Acad Sci USA 71:1612–1617, 1974]. Synthetic oligodeoxy‐ribonucleotide probes (18‐mers) were able to distinguish sequences that differed by a single base pair. Mutant his sequenc... hiện toàn bộ
Mutations induced by (−)‐anti‐11R,12S‐dihydrodiol 13S,14R‐epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells
Environmental and Molecular Mutagenesis - Tập 41 Số 2 - Trang 131-139 - 2003
Brinda Mahadevan, Wan‐Mohaiza Dashwood, Andreas Luch, Arta Pecaj, Johannes Doehmer, Albrecht Seidel, Cliff Pereira, William M. Baird
AbstractThe polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) is an exceptionally potent carcinogen. Its direct DNA‐reactive metabolite, the fjord region (−)‐anti‐11R,12S‐dihydrodiol 13S,14R‐epoxide [(−)‐anti‐DB[a,l]PDE], was used to investigate induction of mutations in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells. Cells expo... hiện toàn bộ
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