A brief overview of mechanisms of mitochondrial toxicity from NRTIs
Tóm tắt
Nucleoside reverse transcriptase inhibitors (NRTIs) in combinations with other antiretrovirals (highly active antiretroviral therapy, HAART) are the cornerstones of AIDS therapy, turning HIV infection into a manageable clinical entity. Despite the initial positive impact of NRTIs, therapeutic experience revealed serious side effects that appeared to originate in the mitochondria and which ultimately manifested as dysfunction of that organelle. It may be reasonable to consider that as the AIDS epidemic continues and as survival with HIV infection is prolonged by treatment with HAART, long‐term side effects of NRTIs may become increasingly common. This consideration may be underscored in children who are born to HIV‐infected mothers who received NRTI therapy
Từ khóa
Tài liệu tham khảo
Chen CH, 1991, Effect of anti‐human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity, Mol Pharmacol, 39, 625
Copeland WC, 1992, Human DNA polymerases α and β are able to incorporate anti‐HIV deoxynucleotides into DNA, J Biol Chem, 267, 21459, 10.1016/S0021-9258(19)36631-1
Huang P, 1992, Selective action of 2′,3′‐didehydro‐2′,3′‐dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases, J Biol Chem, 267, 2817, 10.1016/S0021-9258(18)45952-2
Lamperth L, 1991, Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model, Lab Invest, 65, 742
Lewis W, 1991, Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts, Lab Invest, 65, 228
Lewis W, Antiretroviral nucleosides, deoxynucleotide carrier, and mitochondrial DNA: Evidence supporting the DNA pol γ hypothesis, AIDS
Moraes CT, 1991, mtDNA depletion with variable tissue expression: A novel genetic abnormality in mitochondrial diseases, Am J Hum Genet, 48, 492
Nickel W, 1992, Interactions of azidothymidine triphosphate with the cellular DNA polymerases α, δ, and ϵ and with DNA primase, J Biol Chem, 267, 848, 10.1016/S0021-9258(18)48361-5
Nolan D, 2004, The role of nucleoside reverse transcriptase inhibitors in the fat redistribution syndrome, J HIV Ther, 9, 34
Parker WB, 1994, Mitochondrial toxicity of NRTI analogs, J NIH Res, 6, 57